CAR T Cells in Solid Tumors: Current State and Future Direction
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 780
Special Issue Editors
Interests: angiogenesis; immunotherapy; vascular biology
Special Issues, Collections and Topics in MDPI journals
Interests: CAR T cells; immunotherapy
Special Issue Information
Dear Colleagues,
CAR T-cell therapy has achieved unprecedented clinical responses against certain advanced and treatment refractory B lymphocyte malignancies, leading to first regulatory approval of CD19-directed CAR-T cells in 2018. Non-hematological solid tumors, however, have proven less responsive to CAR T-cells, and cross-reactivity against healthy tissues is an important safety issue. Limited homing, along with barriers imposed by the stroma, can restrict the number of CAR-T cells reaching the solid tumor bed. Moreover, a range of obstacles, including limited oxygen and nutrients, as well as the presence of suppressive immune infiltrate, can lead to CAR-T cell anergy or exhaustion. This Special Issue aims to provide the current status of CAR T cells in the treatment of solid tumors, as well cutting-edge cell culture, CAR-design, gene-engineering, and combinatorial approaches for overcoming challenges in the field.
Prof. Dr. Arjan Griffioen
Dr. Melita Irving
Prof. George Coukos
Guest Editors
Manuscript Submission Information
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Keywords
- CAR T cells
- solid tumors
- combination therapy
- checkpoint inhibitors
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