Circular RNAs: New Insights into the Molecular Biology of Cancer

Dear Colleagues,

Circular RNAs (circRNAs) are a new RNA type, derived from back-splicing. circRNAs have peaked researchers’ interest due to their widespread expression and multifaceted role. More specifically, they can act as microRNA sponges, protein sponges or scaffolds, and encode for peptides. Additionally, they play regulatory roles in several cellular processes, including signaling and alternative splicing, both in physiological and pathological states. In particular, their expression has been associated with several aspects of cancer cell life, for instance proliferation and migration, while several studies highlight their value as cancer biomarkers and therapeutic targets. The existing findings, combined with the fact that the cancer initiation and progression mechanisms are not well understood yet, support the further investigation of circRNAs in the field of cancer pathobiology.

This Special Issue will focus on the role of circRNAs in cancer, covering molecular, cellular and (pre)clinical aspects, aiming to enlighten the implication of circRNAs in human malignancies. The authors are encouraged to submit their original research studies concerning this topic. Reviews that highlight new findings in the above areas are also welcome. Ι hope that this Special Issue regarding circRNAs in cancer will interest the readers of Cancers.

Dr. Christos K. Kontos
Guest Editor

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