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Cancers
Special Issues
Efficacy and Complications of Liver Resection for Liver Cancer
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Efficacy and Complications of Liver Resection for Liver Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 3348

Special Issue Editors

Prof. Dr. Massimo Rossi

E-Mail Website
Guest Editor
General Surgery and Organ Transplantation Unit, Sapienza University of Rome, 00161 Rome, Italy
Interests: liver transplantation; hepatocellular cancer; cholangiocellular cancer; colorectal liver metastases; hepatic resection; mini-invasive liver surgery; renal transplantation; pancreas transplantation
Prof. Dr. Quirino Lai

E-Mail Website
Guest Editor
General Surgery and Organ Transplantation Unit, Sapienza University of Rome, 00161 Rome, Italy
Interests: hepatocellular carcinoma; liver transplantation; hepatic resection; prognostic algorithms; therapeutic algorithms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Silvia Quaresima

E-Mail Website
Guest Editor
General Surgery and Organ Transplantation Unit, Sapienza University of Rome, 00161 Rome, Italy
Interests: liver transplantation; hepatocellular cancer; cholangiocellular cancer; colorectal liver metastases; hepatic resection; mini-invasive liver surgery; renal transplantation; bariatric surgery

Special Issue Information

Dear Colleagues,

Liver resection represents one of the most successful strategies for the management of several different types of primitive and secondary liver cancer.

This Special Issue on “Efficacy and Complications of Liver Resection for Liver Cancer” will address the current efforts and advances in the field of liver resection.

In particular, the first aim of this Special Issue will be to report the development of new technologies aimed at improving surgical quality in terms of post-operative death or tumor-free survival.

As the second aim, special attention will be given to the complications correlated with the surgical approach, with the intent to minimize the potential risks connected with surgery.

The Special Issue will show different international perspectives of improving the quality of hepatic resection.

We hope that this Special Issue facilitates recognition and understanding of the importance of new technologies and the role of preventing post-operative complications in the use of liver resection for the management of liver cancer.

Prof. Dr. Massimo Rossi
Prof. Dr. Quirino Lai
Prof. Dr. Silvia Quaresima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatocellular cancer
  • cholangiocellular cancer
  • colorectal liver metastases
  • alpha-fetoprotein
  • PIVKA
  • laparoscopy
  • comprehensive complication index
  • inflammatory markers

Published Papers (2 papers)

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12 pages, 958 KiB  
Article
Prevention of Post-Hepatectomy Liver Failure in Cirrhotic Patients Undergoing Minimally Invasive Liver Surgery for HCC: Has the Round Ligament to Be Preserved?
by Marco Vivarelli, Federico Mocchegiani, Taiga Wakabayashi, Federico Gaudenzi, Daniele Nicolini, Malek A. Al-Omari, Grazia Conte, Alessandra Borgheresi, Andrea Agostini, Roberta Rossi, Yoshiki Fujiyama, Andrea Giovagnoni, Go Wakabayashi and Andrea Benedetti Cacciaguerra
Cancers 2024, 16(2), 364; https://doi.org/10.3390/cancers16020364 - 15 Jan 2024
Viewed by 1009
Abstract
Post-hepatectomy liver failure (PHLF) represents a major cause of morbidity and mortality after liver resection. The factors related to PHLF are represented not only by the volume and function of the future liver remnant but also by the severity of portal hypertension. The [...] Read more.
Post-hepatectomy liver failure (PHLF) represents a major cause of morbidity and mortality after liver resection. The factors related to PHLF are represented not only by the volume and function of the future liver remnant but also by the severity of portal hypertension. The aim of this study was to assess whether the preservation of the round ligament (RL) may mitigate portal hypertension, thus decreasing the risk of PHLF and ascites in cirrhotic patients while undergoing minimally invasive liver surgery (MILS). All the cirrhotic patients who underwent MILS for HCC from 2016 to 2021 in two international tertiary referral centers were retrospectively analyzed, comparing cases with the RL preserved vs. those with the RL divided. Only patients with cirrhosis ≥ Child A6, portal hypertension, and ICG-R15 > 10% were included. Main postoperative outcomes were compared, and the risk factors for postoperative ascites (severe PHLF, grade B/C) were investigated through a logistic regression. After the application of the selection criteria, a total of 130 MILS patients were identified, with 86 patients with the RL preserved and 44 with the RL divided. The RL-preserved group showed lower incidences of severe PHLF (7.0% vs. 20.5%, p = 0.023) and ascites (5.8% vs. 18.2%, p = 0.026) in comparison with the RL-divided group. After uni/multivariate analysis, the risk factors related to postoperative ascites were RL division and platelets < 92 × 103/µL, calculated with ROC analysis. The preservation of the round ligament during MILS may mitigate portal hypertension, preventing PHLF and ascites in cirrhotic patients with borderline liver function. Full article
(This article belongs to the Special Issue Efficacy and Complications of Liver Resection for Liver Cancer)
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11 pages, 3116 KiB  
Systematic Review
Effect of Autotransfusion in HCC Surgery on Survival and Recurrence: A Systematic Review and Meta-Analysis
by Anastasia Murtha-Lemekhova, Juri Fuchs, Emil Ritscher and Katrin Hoffmann
Cancers 2022, 14(19), 4837; https://doi.org/10.3390/cancers14194837 - 3 Oct 2022
Cited by 3 | Viewed by 1803
Abstract
Background: The chronic blood shortage has forced clinicians to seek alternatives to allogeneic blood transfusions during surgery. Due to anatomic uniqueness resulting in a vast vasculature, liver surgery can lead to significant blood loss, and an estimated 30% of patients require blood transfusions [...] Read more.
Background: The chronic blood shortage has forced clinicians to seek alternatives to allogeneic blood transfusions during surgery. Due to anatomic uniqueness resulting in a vast vasculature, liver surgery can lead to significant blood loss, and an estimated 30% of patients require blood transfusions in major hepatectomy. Allogeneic transfusion harbors the risk of an immunologic reaction. However, the hesitation to reinfuse a patient’s own blood during cancer surgery is reinforced by the potentiality of reintroducing and disseminating tumor cells into an individual undergoing curative treatment. Two methods of autotransfusions are common: autotransfusion after preoperative blood donation and intraoperative blood salvage (IBS). We aim to investigate the effect of autotransfusion on recurrence and survival rates of patients undergoing surgery for HCC. Methods: The protocol for this meta-analysis was registered at PROSPERO prior to data extraction. MEDLINE, Web of Science and Cochrane Library were searched for publications on liver surgery and blood salvage (autologous transfusion or intraoperative blood salvage). Comparative studies were included. Outcomes focused on long-term oncologic status and mortality. Hazard ratios (HR) estimated outcomes with a fixed-effects model. Risk of bias was assessed using ROBINS-I, and certainty of evidence was evaluated with GRADE. Separate analyses were performed for liver transplantation and hepatectomies. Results: Fifteen studies were included in the analysis (nine on transplantation and six on hepatectomies), and they comprised 2052 patients. Overall survival was comparable between patients who received intraoperative blood salvage (IBS) or not for liver transplantation (HR 1.13, 95% CI [0.89, 1.42] p = 0.31). Disease-free survival also was comparable (HR 0.97, 95% CI [0.76, 1.24], p = 0.83). Autotransfusion after prior donation was predominantly used in hepatectomy. Patients who received autotransfusion had a significantly better overall survival than the control (HR 0.71, 95% CI [0.58, 0.88], p = 0.002). Disease-free survival was also significantly higher in patients with autotransfusion (HR 0.88, 95% CI [0.80, 0.96], p = 0.005). Although overall, the certainty of evidence is low and included studies exhibited methodological heterogeneity, the heterogeneity of outcomes was low to moderate. Conclusion: Autotransfusion, including intraoperative blood salvage, does not adversely affect the overall or disease-free survival of patients with HCC undergoing resection or transplantation. The results of this meta-analysis justify a randomized-controlled trial regarding the feasibility and potential benefits of autotransfusion in HCC surgery. Full article
(This article belongs to the Special Issue Efficacy and Complications of Liver Resection for Liver Cancer)
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