Molecular Mechanisms in Bone and Soft Tissue Sarcomas

Dear Colleagues,

Bone and soft tissue sarcomas are rare, but disproportionately lethal cancers. Despite having a common cell of origin, there are a multitude of subtypes characterized by a significant genetic heterogeneity. This tumor heterogeneity has limited treatment progress, as a “one size fits all” approach has demonstrated limited efficacy. While surgery and adjuvant therapies are typically considered the mainstay of treatment, evolving understanding of the molecular underpinnings of these tumors, is revolutionizing the care of these tumors.

This Special Issue aims to update the current knowledge and future implications of the molecular underpinnings of bone and soft tissue sarcomas in order to highlight the current understanding of these tumors on a molecular level and the promising therapeutic approaches in the treatment of these challenging disease entities. Continued research is needed to identify the current obstacles and explore novel solutions to help optimize patient care, with a focus on how improved understanding of the molecular basis for these tumors translates to the clinical realm.

Dr. Alexander L. Lazarides
Dr. Zachary D.C. Burke
Guest Editors

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• sarcoma
• bone sarcoma
• soft tissue sarcoma
• osteosarcoma
• molecular level
• translation