Hepatobiliary Cancers: Infection, Inflammation and Therapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 982

Special Issue Editors


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Guest Editor
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
Interests: chemical biology; epigenetics; drug design; fibrosis; RNA–small molecule interaction
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan 200005, Nigeria
Interests: chemical carcinogenesis; biochemical toxicology; genetics; oxidative stress; toxicology

Special Issue Information

Dear Colleagues,

Reports in the literature have established that controlled inflammation is a protective response mount by the immune system against infections and tissue injuries. When uncontrolled, however, inflammation could drive and sustain autoimmunity and malignant transformations, including hepatobiliary cancers such as liver cancer, gall bladder cancer, and cholangiocarcinomas. This Special Issue of Cancers focuses on the complex interplay between chronic infections, the ensuing inflammation, inflammation from alternative risk factors, immune regulations, and the development or pre-disposition to hepatobiliary cancers. We invite from the academic community manuscripts describing original research findings and review articles that cover all aspects of the mechanisms of the etiology of hepatobiliary cancers and novel therapeutic modalities.

Dr. Adegboyega K. Oyelere
Dr. Solomon E. Owumi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver cancer
  • gall bladder cancer
  • cholangiocarcinomas
  • risk factors
  • inflammation
  • oxidative stress
  • virus infections
  • bacterial infections
  • immune system and therapy

Published Papers (1 paper)

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Review

16 pages, 690 KiB  
Review
The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis
by Mario Capasso, Valentina Cossiga, Maria Guarino, Luisa Ranieri and Filomena Morisco
Cancers 2024, 16(8), 1505; https://doi.org/10.3390/cancers16081505 - 15 Apr 2024
Viewed by 631
Abstract
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis [...] Read more.
Recently, metabolic associated steatotic liver disease (MASLD) became the leading cause of chronic liver disease worldwide and one of the most frequent causes of hepatocellular carcinoma (HCC). Nonetheless, in this epidemiological trend, viral hepatitis remains the major driver in hepatic carcinogenesis. Globally, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma, with an overall attributable risk of approximately 40%, followed by hepatitis C virus (HCV), which accounts for 28–30% of cases, with significant geographic variations between the Eastern and Western world. Considering all the etiologies, HCC risk increases proportionally with the progression of liver disease, but the risk is consistently higher in patients with viral triggers. This evidence indicates that both direct (due to the oncogenic properties of the viruses) and indirect (through the mechanisms of chronic inflammation that lead to cirrhosis) mechanisms are involved, alongside the presence of co-factors contributing to liver damage (smoking, alcohol, and metabolic factors) that synergistically enhance the oncogenic process. The aim of this review is to analyze the oncogenic role of hepatitis viruses in the liver, evaluating epidemiological changes and direct and indirect viral mechanisms that lead to liver cancer. Full article
(This article belongs to the Special Issue Hepatobiliary Cancers: Infection, Inflammation and Therapy)
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