Management of Hepatocellular Carcinoma in Liver Disease
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 20454
Special Issue Editors
Interests: viral hepatitis; cirrhosis; clinical research; outcome; surveillance; auto-immune and cholestatic liver diseases
Special Issue Information
Dear Colleagues,
Each year, over 900,000 patients are diagnosed with hepatocellular carcinoma (HCC) worldwide. It is the 3rd most common cause of cancer-related death, which highlights the poor prognosis of HCC and the importance of early diagnosis with the possibility of curative locoregional therapy or liver transplantation. Improving the efficacy of HCC surveillance is therefore an ongoing focus of the field. As there is a clear relation between HCC and pre-existing liver disease, with HCC predominantly developing in those who progressed to cirrhosis, many tumors can be prevented by adequate suppression of the aetiolofical factor driving hepatic inflammation and fibrogenesis. With viral hepatitis as the main global cause of HCC, the new effective antiviral therapies may thus substantially reduce the burden of HCC. Yet, non-alcoholic fatty liver disease is now increasingly identified as an important risk factor for HCC, even prior to the stage of cirrhosis. This poses new challenges due to the rising incidence of steatosis with a negative impact on the diagnostic sensitivity for HCC. Although immune-oncologic systemic approaches have recently improved treatment outcomes for a subgroup of patients, HCC will remain a global health problem for many years.
An upcoming special edition of Cancers aims to adress the questions associated with diagnosis and management of HCC in patients with liver disease from a broad perspective. We kindly invite and motivate all to submit their work related to this topic.
Dr. Adriaan J. van der Meer
Dr. Dave Sprengers
Guest Editors
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Keywords
- hepatocellular carcinoma
- epidemiology
- surveillance
- biomarkers
- treatment
- liver transplantation
- liver disease
- cirrhosis
- non-cirrhosis
- outcome
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