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Cancers
Special Issues
Biological, Clinical and Epidemiological Features of Human Papillomavirus-Associated Cancers
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Biological, Clinical and Epidemiological Features of Human Papillomavirus-Associated Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Infectious Agents and Cancer".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 7219

Special Issue Editor

Dr. Miguel Ángel Pavón

E-Mail Website
Guest Editor
1. Infections and Cancer Laboratory/Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) and Bellvitge Institute of Biomedical Research (IDIBELL), Barcelona, Spain
2. Centro de Investigación Biomédica en Red en Cáncer (CIBER-ONC), Madrid, Spain
Interests: cancer; human papillomavirus; HNSCC; molecular markers; infectivity; transmission; in vitro models; new assay validation; VSCC

Special Issue Information

Dear Colleagues,

Human papillomavirus (HPV) causes more than 5% of cancers worldwide, including almost all cervical cancers. HPV is also associated with a significant proportion of other anogenital lesions, such as anal, vulvar, vaginal, penile, or oropharyngeal cancer, whose incidence has been increasing in Western countries in recent decades.

Advances in the knowledge of HPV natural history and biology has been crucial for developing strategies to prevent cervical cancer, based on the use of prophylactic vaccines or screening programs using HPV detection assays. HPV-associated markers are used to identify a subtype of oropharyngeal tumors with different molecular characteristics and clinical behavior.

However, many questions are still to be addressed, such as developing triage biomarkers for identifying HPV infections, with an increased risk of progression, or effective strategies for limiting HPV transmission in adults. Accurate molecular markers for screening, prevention, and treatment of oropharyngeal and other non-cervical anogenital HPV cancers would enable the diagnosis of treatable and curable stages. 

This Special Issue will include original works and reviews describing recent advances and challenges in the screening, diagnosis, and treatment of HPV-driven cancers. We also welcome manuscripts describing biological and epidemiological features, crucial to understanding the natural history of these tumors.

You may choose our Joint Special Issue in Current Oncology.

Dr. Miguel Ángel Pavón
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV
  • screening

Published Papers (3 papers)

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Research

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14 pages, 3618 KiB  
Article
Effects of Human Papilloma Virus E6/E7 Oncoproteins on Genomic Structure in Head and Neck Squamous Cell Carcinoma
by Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li and Weg M. Ongkeko
Cancers 2022, 14(24), 6190; https://doi.org/10.3390/cancers14246190 - 15 Dec 2022
Cited by 1 | Viewed by 1547
Abstract
Human Papilloma Virus (HPV) is highly prevalent within the U.S., with studies estimating that over 80% of individuals will contract the virus in their lifetime. HPV is considered a primary risk factor for the development and progression of oropharyngeal cancers. The impact of [...] Read more.
Human Papilloma Virus (HPV) is highly prevalent within the U.S., with studies estimating that over 80% of individuals will contract the virus in their lifetime. HPV is considered a primary risk factor for the development and progression of oropharyngeal cancers. The impact of the HPV virus’s E6 and E7 oncoproteins on cellular signaling pathways and genomic integration has been extensively characterized. Indirect genomic effects; however, remain relatively unidentified. In this study, we analyzed 83 HPV+ Head and Neck Squamous Cell Carcinoma (HNSCC) patients of varying HPV types. Expression counts of the HPV E6 and E7 oncogenes were estimated across samples and correlated with genomic mutational classes. High expression of E6 and E7 oncoproteins was associated with a greater number of total point mutations, especially on chromosomes 1, 11, and 17, which have been implicated in HPV-mediated cancers in previous studies. Samples with high E6 and E7 expression also exhibited more frequent non-clustered structural variation and a lack of clustered variation altogether. Copy number segments were present with fewer number of repeats in high E6 and E7 expression samples, which is known to correlate with decreased expression of affected genes. E6 and E7 expression was associated with increased activity of several cellular pathways associated in oncogenesis and telomere maintenance. In comprehensively characterizing the effects of the HPV oncoproteins on the human genome, potential mechanisms of HNSCC pathogenesis may be further elucidated. Full article
(This article belongs to the Special Issue Biological, Clinical and Epidemiological Features of Human Papillomavirus-Associated Cancers)
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17 pages, 1132 KiB  
Article
Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix
by Karen Bräutigam, Stefanie Meier, Sabina Meneder, Louisa Proppe, Katharina Stroschein, Stephan Polack, Frank Köster, Achim Rody and Sascha Baum
Cancers 2022, 14(13), 3136; https://doi.org/10.3390/cancers14133136 - 26 Jun 2022
Cited by 7 | Viewed by 1919
Abstract
Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections. Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. [...] Read more.
Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections. Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. HPV genotyping was performed using the EUROArray HPV test. Results: Positivity of HR HPV was found in 60.4–64.3% of anogenital and 14.6% of oral samples. HPV 16 showed the highest incidence in all investigated areas. In cervical and vaginal samples HPV 31 was detected second most, while in vulvar, anal, and oral samples HPV 53 was the second most common subtype. HPV 18 was found lower in all areas, while HPV 51, HPV 52, and HPV 73 were detected higher than expected from published data. A good concordance between cervical, vaginal and vulvar samples was examined for most of the HPV. HR HPV infection was higher in cervical cancer (CC; 91.7%) and high-grade intraepithelial squamous lesions (HSIL; 93.9%) compared to low-grade SIL (LSIL; 69.6%) and normal samples (44.8%). Conclusion: In addition to the well described HPV subtypes, we found others with high incidences in the investigated areas which may be evident for HSIL and CC of those areas. Full article
(This article belongs to the Special Issue Biological, Clinical and Epidemiological Features of Human Papillomavirus-Associated Cancers)
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Review

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19 pages, 733 KiB  
Review
The Involvement of Human Papilloma Virus in Gastrointestinal Cancers
by Jacek Baj, Alicja Forma, Iga Dudek, Zuzanna Chilimoniuk, Maciej Dobosz, Michał Dobrzyński, Grzegorz Teresiński, Grzegorz Buszewicz, Jolanta Flieger and Piero Portincasa
Cancers 2022, 14(11), 2607; https://doi.org/10.3390/cancers14112607 - 25 May 2022
Cited by 6 | Viewed by 3284
Abstract
Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections worldwide. HPV infection has a strong relationship with the onset of cervix uteri, vagina, penis, anus, and oropharynx, but also tonsils and tongue cancers. Some epidemiological data indicate that except [...] Read more.
Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections worldwide. HPV infection has a strong relationship with the onset of cervix uteri, vagina, penis, anus, and oropharynx, but also tonsils and tongue cancers. Some epidemiological data indicate that except for gynecologic cancers, HPV infection can be one of the risk factors associated with a greater risk of induction and progression of gastrointestinal cancers. Data, however, remain contradictory and definite conclusions cannot be drawn, so far. The following review aims to organize recent evidence and summarize the current state of knowledge regarding the association between HPV infection and gastrointestinal tumors primarily focusing on esophageal, liver, gastric, colorectal, and anal cancers. Full article
(This article belongs to the Special Issue Biological, Clinical and Epidemiological Features of Human Papillomavirus-Associated Cancers)
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