Feature Review Paper Special Issue in Section Molecular Cancer Biology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 469

Special Issue Editor


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Guest Editor
Experimental Neurosurgery, Neuroscience Center, Goethe-University Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
Interests: brain tumors; intrinsic and acquired therapy resistance; apoptosis; autophagy; mitochondria as targets for cancer therapy; mechanisms of tumor cell migration and invasion
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Special Issue Information

Dear Colleagues,

The Section “Molecular Cancer Biology” covers all aspects of molecular and cellular biology related to the development, progression and therapy of cancer. We are pleased to announce this Special Issue, to which I would like to invite you to contribute a paper. In this Special Issue, reviews and systematic reviews focusing on the most significant developments and the current progress in this area of research will be included. We welcome the submission of manuscripts related to all topics of interest, as listed below.

The topics of interest include the following:

  • Oncogenesis and cancer progression;
  • Cancer immunology and immunotherapy;
  • Drug discovery and targeted therapy;
  • Gene therapy;
  • Tumor invasion and metastasis;
  • Cancer stem cell biology;
  • Genomic instability;
  • DNA damage and repair;
  • Cell cycle regulation;
  • Hypoxia;
  • Cancer cell metabolism;
  • Mechanisms of therapy resistance;
  • Autophagy;
  • Apoptosis;
  • Necrosis;
  • Senescence;
  • Angiogenesis;
  • Inflammation and cancer;
  • Epigenetics and cancer;
  • Molecular profiling of cancer.

Prof. Dr. Donat Kögel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular biology
  • cell biology
  • cancer
  • tumor
  • cancer cell

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Published Papers (1 paper)

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Review

11 pages, 1597 KiB  
Review
Minimal Requirements for Cancer Initiation: A Comparative Consideration of Three Prototypes of Human Leukemia
by Toshiyuki Hori
Cancers 2024, 16(17), 3109; https://doi.org/10.3390/cancers16173109 - 9 Sep 2024
Viewed by 386
Abstract
Even if its completed form is complex, cancer originates from one or two events that happened to a single cell. A simplified model can play a role in understanding how cancer initiates at the beginning. The pathophysiology of leukemia has been studied in [...] Read more.
Even if its completed form is complex, cancer originates from one or two events that happened to a single cell. A simplified model can play a role in understanding how cancer initiates at the beginning. The pathophysiology of leukemia has been studied in the most detailed manner among all human cancers. In this review, based on milestone papers and the latest research developments in hematology, acute promyelocytic leukemia (APL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML) with RUNX1-RUNX1T1 are selected to consider minimal requirements for cancer initiation. A one-hit model can be applied to the initiation of APL and CML whereas a two-hit model is more suitable to the initiation of AML with RUNX1-RUNX1T1 and other AMLs. Even in cancer cells with multiple genetic abnormalities, there must be a few mutant genes critical for the mutant clone to survive and proliferate. Such genes should be identified and characterized in each case in order to develop individualized target therapy. Full article
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