Machine Learning and Radiomics Applications of MRI-Guided Treatments in Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 6947

Special Issue Editor


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Guest Editor
Department of Medical Physics, Memorial Sloan Kettering Cancer Centre, New York, NY, USA
Interests: Machine learning, deep learning, radiomics biomarkers, MRI guided treatments, image segmentation, longitudinal response assessment

Special Issue Information

Dear colleagues,

Advances in artificial intelligence and machine learning over the recent years including deep learning has spurred a lot of interest and applications of these techniques in several aspects of medicine including cancer diagnosis and treatment. Automated methods for analyzing medical images, including deep learning based detection and segmentation of cancers and normal organs, automated biomarkers for diagnosis and classification of cancer aggressiveness and prediction of outcomes will provide more reproducible and quantitative biomarkers to target and treat cancers. However, the automated analysis of biomedical images is generally restricted to computed tomography (CT) scans mostly due to their higher prevalence and use for cancer diagnosis and follow ups as well as the relative robustness of the scans to scanning variations compared to magnetic resonance imaging (MRI). Nevertheless, MRI provides higher soft-tissue contrast, thereby enabling better visualization of the tumors. MRI guidance is also a new technique for novel treatments like MRI-guided radiation therapy.

The purpose of this special issue is to highlight the advances in all aspects of machine learning, both deep learning and standard radiomics based machine learning applied to MRI for the purpose of robust detection, prognosis, prediction of response to cancer treatments. Submissions focusing on using MRI for cancer response assessment/prediction, improving robustness and reproducibility of MRI radiomics, classification or segmentation from MRI, and methods combining MRI with other imaging or non-imaging modalities are highly relevant.

Dr. Harini Veeraraghavan
Guest Editor

Manuscript Submission Information

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Keywords

  • MRI guided treatments
  • deep learning
  • machine learning
  • MRI harmonization
  • radiomics
  • MRI biomarkers

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Published Papers (2 papers)

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Research

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14 pages, 4207 KiB  
Article
Deep Learning for Fully Automatic Tumor Segmentation on Serially Acquired Dynamic Contrast-Enhanced MRI Images of Triple-Negative Breast Cancer
by Zhan Xu, David E. Rauch, Rania M. Mohamed, Sanaz Pashapoor, Zijian Zhou, Bikash Panthi, Jong Bum Son, Ken-Pin Hwang, Benjamin C. Musall, Beatriz E. Adrada, Rosalind P. Candelaria, Jessica W. T. Leung, Huong T. C. Le-Petross, Deanna L. Lane, Frances Perez, Jason White, Alyson Clayborn, Brandy Reed, Huiqin Chen, Jia Sun, Peng Wei, Alastair Thompson, Anil Korkut, Lei Huo, Kelly K. Hunt, Jennifer K. Litton, Vicente Valero, Debu Tripathy, Wei Yang, Clinton Yam and Jingfei Maadd Show full author list remove Hide full author list
Cancers 2023, 15(19), 4829; https://doi.org/10.3390/cancers15194829 - 2 Oct 2023
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Abstract
Accurate tumor segmentation is required for quantitative image analyses, which are increasingly used for evaluation of tumors. We developed a fully automated and high-performance segmentation model of triple-negative breast cancer using a self-configurable deep learning framework and a large set of dynamic contrast-enhanced [...] Read more.
Accurate tumor segmentation is required for quantitative image analyses, which are increasingly used for evaluation of tumors. We developed a fully automated and high-performance segmentation model of triple-negative breast cancer using a self-configurable deep learning framework and a large set of dynamic contrast-enhanced MRI images acquired serially over the patients’ treatment course. Among all models, the top-performing one that was trained with the images across different time points of a treatment course yielded a Dice similarity coefficient of 93% and a sensitivity of 96% on baseline images. The top-performing model also produced accurate tumor size measurements, which is valuable for practical clinical applications. Full article
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25 pages, 2610 KiB  
Review
New Frontiers in Colorectal Cancer Treatment Combining Nanotechnology with Photo- and Radiotherapy
by Sara C. Freitas, Daniel Sanderson, Sofia Caspani, Ricardo Magalhães, Belén Cortés-Llanos, Andreia Granja, Salette Reis, João Horta Belo, José Azevedo, Maria Victoria Gómez-Gaviro and Célia Tavares de Sousa
Cancers 2023, 15(2), 383; https://doi.org/10.3390/cancers15020383 - 6 Jan 2023
Cited by 17 | Viewed by 4337
Abstract
Colorectal cancer is the third most common cancer worldwide. Despite recent advances in the treatment of this pathology, which include a personalized approach using radio- and chemotherapies in combination with advanced surgical techniques, it is imperative to enhance the performance of these treatments [...] Read more.
Colorectal cancer is the third most common cancer worldwide. Despite recent advances in the treatment of this pathology, which include a personalized approach using radio- and chemotherapies in combination with advanced surgical techniques, it is imperative to enhance the performance of these treatments and decrease their detrimental side effects on patients’ health. Nanomedicine is likely the pathway towards solving this challenge by enhancing both the therapeutic and diagnostic capabilities. In particular, plasmonic nanoparticles show remarkable potential due to their dual therapeutic functionalities as photothermal therapy agents and as radiosensitizers in radiotherapy. Their dual functionality, high biocompatibility, easy functionalization, and targeting capabilities make them potential agents for inducing efficient cancer cell death with minimal side effects. This review aims to identify the main challenges in the diagnosis and treatment of colorectal cancer. The heterogeneous nature of this cancer is also discussed from a single-cell point of view. The most relevant works in photo- and radiotherapy using nanotechnology-based therapies for colorectal cancer are addressed, ranging from in vitro studies (2D and 3D cell cultures) to in vivo studies and clinical trials. Although the results using nanoparticles as a photo- and radiosensitizers in photo- and radiotherapy are promising, preliminary studies showed that the possibility of combining both therapies must be explored to improve the treatment efficiency. Full article
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