Understanding and Modelling Metabolic Reprogramming in Breast Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 26730
Special Issue Editors
Interests: breast cancer; tumour microenvironment; cancer metabolism; oxidative stress; immune system; cancer models; bioengineering
Special Issue Information
Dear Colleagues,
Deregulated cellular metabolism is a hallmark of breast cancer and a critical feature of breast neoplastic progression. Similar to other cancer types, breast cancer, compared with healthy tissues, is characterized by elevated levels of aerobic glycolysis, glutaminolysis and heightened flux through the pentose phosphate pathway. These features are both temporally and spatially tunable, allowing tumour cells to react to cues and stresses originating in their internal and local environments. This metabolic flexibility inevitably causes a high degree of heterogeneity that poses a great challenge for therapies against metabolic vulnerabilities.
Understanding and dissecting breast cancer metabolic networks is a complex problem that calls for multidisciplinary approaches. This Special Issue will bring together scientists from diverse disciplines such as cell biology, computer science, immunology, physics and bioengineering worlds. The goal is to harness breast cancer metabolism through the acquisition of a highly comprehensive knowledge and the generation of cellular models that closely mimic the metabolic aspects of this disease.
Dr. Gorrini Chiara
Prof. Dr. Jason Matthews
Guest Editors
Manuscript Submission Information
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Keywords
- cancer metabolism
- oxidative stress
- 3D models
- tumour microenvironment
- heterogeneity
- imaging
- modelling
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