Notch Signaling Pathway in Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 11452
Special Issue Editor
Special Issue Information
Dear Colleagues,
Notch signaling is a highly conserved pathway and a key player of cell fate determination, embryonic development and adult tissue homeostasis. In carcinogenesis, Notch signaling has been found to be frequently altered and to either act as an oncogene or tumor suppressor depending on the tissue and cellular context. Oncogenic activation of Notch signaling has been linked to increased cellular proliferation, reduced apoptosis, suppression of cellular differentiation and induction of cancer stem cell features. Over the last several years, it has become clear that the bidirectional interaction between cancer cells and non-neoplastic cells of the tumor microenvironment is required for cancer progression and metastasis. As Notch is activated through the binding of transmembrane ligands on neighboring cells, altered expression of Notch receptor ligands on cells of the tumor microenvironment may induce aberrant Notch signaling in tumor cells. Along this line, the critical role of Notch signaling has been highlighted in the overall regulation of tumor angiogenesis, whereby the induction of Notch signaling in endothelial cells may either promote or inhibit tumor progression. In addition, non-canonical Notch signaling may antagonize Wnt/β-catenin signaling independent of Notch ligand-dependent cleavage or nuclear localization. Thus, inhibition of Notch signaling is considered a promising therapeutic option in certain cancers, but the molecular mechanisms of Notch signal transduction have not yet been fully uncovered.
This Special Issue will highlight basic and preclinical aspects of the role of Notch signaling in cancers that will advance our understanding of the underlying molecular mechanisms.
I am looking forward to your contributions and exciting findings.
Dr. Stephanie Roessler
Guest Editor
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Keywords
- notch
- cancer
- tumorigenesis
- metastasis
- invasion
- cancer progression
- signaling
- therapy
- tumor microenvironment
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