Oncolytic Virus Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 85696
Special Issue Editors
2. Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg
Interests: oncolytic viruses; rodent protoparvoviruses; combination therapy; immunogenic cell death; virus-host cell interactions
Special Issues, Collections and Topics in MDPI journals
Affiliation 2: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada
Interests: immunotherapies for cancer; oncolytic viruses; exosomes; tumor microenvironment
Special Issue Information
Dear Colleagues,
Oncolytic viruses (OV) are self-propagating agents that can selectively induce the lysis of cancer cells while sparing normal tissues. OV-mediated cancer cell death is often immunogenic and triggers robust anticancer immune responses and immunoconversion of tumor microenvironments. This makes oncolytic virotherapy a promising new form of immunotherapy and OVs ideal candidates for combination therapy with other anticancer agents, including other immunotherapeutics. There are more than 40 OV from nine different families in clinical development and many more at the preclinical stage. Each OV has its own unique characteristics, its pros and cons. Although herpes simplex virus is currently the lead clinical agent, a real champion among the OVs has not yet emerged, justifying the continuous development and optimization of these agents. In this Special Issue of Cancers, we aim to compile reviews that summarize the state-of-the-art and give a comprehensive overview of the OV arena with a particular focus on new trends, directions, challenges, and opportunities.
Dr. Antonio Marchini
Dr. Carolina S. Ilkow
Prof. Alan Melcher
Guest Editors
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Keywords
- oncolytic viruses
- immunotherapy
- combination therapy
- tumor microenvironment
- immunogenic cell death
- new anticancer strategies
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