Pathogenesis, Detection and Spread of Squamous Cell Carcinoma in the Alimentary Tract
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 37509
Special Issue Editors
Interests: medical statistics; systematic review and meta-analysis; esophageal cancer; colorectal cancer; melanoma; surgical oncology
Special Issue Information
Dear Colleagues,
Squamous cell carcinomas of the alimentary tract (head and neck; esophagus; anal canal) are aggressive malignancies with poor prognosis. A better understanding of the mechanisms of carcinogenesis can identify areas of preventive interventions. Head and neck squamous cell carcinoma and esophageal squamous cell carcinoma are associated with elevated mutational load but lacks specific genetic mutations, while anal cancer is very often associated with human papillomavirus. Several evidences suggest a crucial role of the immune system in eradicating such neoplasms. Moreover, checkpoint inhibitors were shown to improve survival in advanced squamous cell carcinomas.
In the future years, we expect an establishment of precision medicine modalities to extend survival and improve quality of life of patients with these neoplasms. Considering such prospective, policy makers and stakeholders can benefit from summarizing efforts aiming at highlighting the most effective approaches and promoting areas of further research.
In this Special Issue of Cancers, we invite systematic reviews to address such challenges for squamous cell carcinomas of the alimentary tract. Topics will include but are not limited to pathogenesis of these cancers; mechanisms of carcinogenesis; immunosurveillance; detection strategies; role of biomarkers; tumor spreading; identification of novel therapeutic targets. This Special Issue aims to highlight the current state in pathogenesis, detection and spread of squamous cell carcinomas of the alimentary tract, and to identify gaps of knowledge.
Mr. Francesco Cavallin
Dr. Marco Scarpa
Guest Editors
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Keywords
- squamous cell carcinoma
- esophagus
- head/neck
- anal canal
- immunology
- oncology
- pathogenesis
- immune surveillance
- HPV
- HIV
- immune suppression
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