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Cancers
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Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and...
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Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 5115

Special Issue Editors

Prof. Dr. Toshihiro Akisue

E-Mail Website
Guest Editor
Department of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan
Interests: bone and soft tissue sarcoma
Dr. Shintaro Iwata

E-Mail Website
Guest Editor
Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Interests: sarcoma; rare cancer; genomics; clinical trial
Special Issues, Collections and Topics in MDPI journals
Dr. Toru Akiyama

E-Mail Website
Guest Editor
School of Medicine, Jichi Medical University, Kawachi District, Shimotsuke, Japan
Interests: osteoclast; osteosarcoma; osteochondroma

Special Issue Information

Dear Colleagues,

Malignant bone and soft tissue tumors are defined as a rare cancer. Since the introduction of perioperative chemotherapy combined with wide surgical excision for several sarcomas, including osteosarcoma and Ewing sarcoma, the prognosis of patients with localized disease has improved. In the past decade, molecular-targeted drugs for soft tissue sarcoma have been developed and used clinically. However, life prognosis, especially for the patients with metastatic or recurrent disease, has not improved in recent decades. As such, novel diagnostic and therapeutic approaches are urgently needed. This Special Issue will focus on recent developments in basic and clinical research for malignant bone and soft tissue tumors. Both original research articles and reviews are welcome. Research topics may include the following:

  • Basic research for molecular mechanisms of sarcoma development;
  • Molecular-targeted drugs for bone and soft tissue sarcoma;
  • Prognostic parameters and biomarkers;
  • New imaging modalities;
  • New surgical options for local treatment;
  • The role of ‘omics’ (genomics, transcriptomics, proteomics, and metabolomics).

We look forward to receiving your contributions.

Prof. Dr. Toshihiro Akisue
Dr. Shintaro Iwata
Dr. Toru Akiyama
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone and soft tissue sarcoma
  • imaging modality
  • surgical treatment
  • systemic treatment
  • molecular-targeted treatment
  • biomarkers
  • prognostic parameters

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Published Papers (4 papers)

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Research

8 pages, 3882 KiB  
Article
Principles and Clinical Application of Free-Style Capillary Perforator-Based Flap for Coverage of Facial Skin Cancer Defects
by Hyung-Sup Shim, Hyun-Jung Ryoo, Jae-Seon Choi, Ji-Ah Park and Youn-Hwan Kim
Cancers 2024, 16(12), 2206; https://doi.org/10.3390/cancers16122206 - 12 Jun 2024
Viewed by 491
Abstract
This study introduces a free-style perforator based island flap (PBIF) for the reconstruction of skin defects. From March 2012 to December 2022, a retrospective investigation was conducted on patients who underwent reconstruction for facial defects due to skin cancer. Data on the patients’ [...] Read more.
This study introduces a free-style perforator based island flap (PBIF) for the reconstruction of skin defects. From March 2012 to December 2022, a retrospective investigation was conducted on patients who underwent reconstruction for facial defects due to skin cancer. Data on the patients’ gender, age, anesthesia method, diagnosis, defect location, flap size, complications, and follow-up periods were collected. There are several principles for designing the PBIF: finger-pinching method, alignment with the direction of wrinkles, the smaller width and longer length of the flap, and proximal attachment to the muscle. A total of 32 patients were included, with an average age of 63.6 years. Surgeries were performed in various regions, such as the infraorbital area, nose, cheek, philtrum, and the anterior/posterior/inferior auricular regions, with an average flap size of 7.63 cm2. There were no complications, such as venous congestion or vascular insufficiency in the skin flaps, although one case required revisional closure due to flap disruption. The PBIF is a useful and effective method for the restoration of facial defects. This method can provide simple yet aesthetically satisfying results, showing stable outcomes without complex surgeries or complications. This study indicates the potential for this method to be more widely employed in reconstructive surgeries in the future. Full article
(This article belongs to the Special Issue Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics)
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16 pages, 4585 KiB  
Article
Therapeutic Potential of Bromodomain and Extra-Terminal Domain Inhibitors for Synovial Sarcoma Cells
by Yuki Kotani, Yoshinori Imura, Sho Nakai, Ryota Chijimatsu, Haruna Takami, Akitomo Inoue, Hirokazu Mae, Satoshi Takenaka, Hidetatsu Outani and Seiji Okada
Cancers 2024, 16(6), 1125; https://doi.org/10.3390/cancers16061125 - 11 Mar 2024
Viewed by 1187
Abstract
Synovial sarcoma (SS), a rare subtype of soft-tissue sarcoma distinguished by expression of the fusion gene SS18-SSX, predominantly affects the extremities of young patients. Existing anticancer drugs have limited efficacy against this malignancy, necessitating the development of innovative therapeutic approaches. Given the established [...] Read more.
Synovial sarcoma (SS), a rare subtype of soft-tissue sarcoma distinguished by expression of the fusion gene SS18-SSX, predominantly affects the extremities of young patients. Existing anticancer drugs have limited efficacy against this malignancy, necessitating the development of innovative therapeutic approaches. Given the established role of SS18-SSX in epigenetic regulation, we focused on bromodomain and extra-terminal domain protein (BET) inhibitors and epigenetic agents. Our investigation of the BET inhibitor ABBV-075 revealed its pronounced antitumor effects, inducing G1-phase cell-cycle arrest and apoptosis, in four SS cell lines. Notably, BET inhibitors exhibited regulatory control over crucial cell-cycle regulators, such as MYC, p21, CDK4, and CDK6. Additionally, RNA sequencing findings across the four cell lines revealed the significance of fluctuating BCL2 family protein expression during apoptotic induction. Notably, variations in the expression ratio of the anti-apoptotic factor BCLxL and the pro-apoptotic factor BIM may underlie susceptibility to ABBV-075. Additionally, knockdown of SS18-SSX, which upregulates BCL2, reduced the sensitivity to ABBV-075. These findings suggest the potential utility of BET inhibitors targeting the SS18-SSX-regulated intrinsic apoptotic pathway as a promising therapeutic strategy for SS. Full article
(This article belongs to the Special Issue Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics)
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14 pages, 3032 KiB  
Article
Beneficial Use of the Combination of Gemcitabine and Dacarbazine in Advanced Soft Tissue Sarcomas: Real-World Data
by Ibon Gurruchaga Sotés, M. Carmen Gómez-Mateo, María Eugenia Ortega Izquierdo and Javier Martínez-Trufero
Cancers 2024, 16(2), 267; https://doi.org/10.3390/cancers16020267 - 8 Jan 2024
Viewed by 1064
Abstract
Background: The combination of gemcitabine and dacarbazine has exhibited efficacy in terms of progression-free survival (PFS) and overall survival (OS) for aSTSs, albeit without robust confirmation from larger clinical trials. Methods: We conducted a retrospective study in a single institution involving aSTS patients [...] Read more.
Background: The combination of gemcitabine and dacarbazine has exhibited efficacy in terms of progression-free survival (PFS) and overall survival (OS) for aSTSs, albeit without robust confirmation from larger clinical trials. Methods: We conducted a retrospective study in a single institution involving aSTS patients treated with gemcitabine and dacarbazine. Results: 95 patients were assessed, pointing to a benefit in PFS of 3.5 months and an OS of 14.2 months. Patients with translocated histotypes had better PFS, while those with platelet–lymphocyte ratios (PLRs) surpassing a specific threshold or lower albumin levels had poorer overall survival. Conclusions: This study validates previous findings from three phase I–II trials, affirming the utility of this treatment approach in routine clinical practice. Full article
(This article belongs to the Special Issue Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics)
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19 pages, 5499 KiB  
Article
EWSR1::ATF1 Orchestrates the Clear Cell Sarcoma Transcriptome in Human Tumors and a Mouse Genetic Model
by Benjamin B. Ozenberger, Li Li, Emily R. Wilson, Alexander J. Lazar, Jared J. Barrott and Kevin B. Jones
Cancers 2023, 15(24), 5750; https://doi.org/10.3390/cancers15245750 - 8 Dec 2023
Cited by 3 | Viewed by 1862
Abstract
Clear cell sarcoma (CCS) is a rare, aggressive malignancy that most frequently arises in the soft tissues of the extremities. It is defined and driven by expression of one member of a family of related translocation-generated fusion oncogenes, the most common of which [...] Read more.
Clear cell sarcoma (CCS) is a rare, aggressive malignancy that most frequently arises in the soft tissues of the extremities. It is defined and driven by expression of one member of a family of related translocation-generated fusion oncogenes, the most common of which is EWSR1::ATF1. The EWSR1::ATF1 fusion oncoprotein reprograms transcription. However, the binding distribution of EWSR1::ATF1 across the genome and its target genes remain unclear. Here, we interrogated the genomic distribution of V5-tagged EWSR1::ATF1 in tumors it had induced upon expression in mice that also recapitulated the transcriptome of human CCS. ChIP-sequencing of V5-EWSR1::ATF1 identified previously unreported motifs including the AP1 motif and motif comprised of TGA repeats that resemble GGAA-repeating microsatellites bound by EWSR1::FLI1 in Ewing sarcoma. ChIP-sequencing of H3K27ac identified super enhancers in the mouse model and human contexts of CCS, which showed a shared super enhancer structure that associates with activated genes. Full article
(This article belongs to the Special Issue Bone and Soft Tissue Tumors: Molecular Mechanisms, Clinical Practice, and Emerging Therapeutics)
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