The Influence of Advances in Head and Neck Imaging on Diagnosis and Treatment of Head and Neck Squamous Cell Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1209

Special Issue Editors


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Guest Editor
Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
Interests: head and neck squamous cell carcinoma; surgical treatment; extracranial stereotactic body radiotherapy; tumor volume; cervical lymph nodes classification; contrast-enhanced computed tomography scans; ultrasound imaging; positron emission tomography; radiomics; artificial intelligence; functional outcome; quality of life

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Co-Guest Editor
University Hospital Innsbruck, Innsbruck, Austria
Interests: head and neck squamous cell carcinoma; surgery

Special Issue Information

Dear Colleagues,

Advancements in the diagnosis of head and neck squamous cell carcinoma have primarily been made in the field of imaging. While more conservative advancements focused on optimizing the use of pre-existing information such as tumor and lymph node volume from readily available staging imaging modalities, recent advancements have included the application of artificial intelligence in the detection and classification of primary tumors and cervical lymph nodes. Although these advancements may ultimately lead to improved decision making by interdisciplinary tumor boards, the influences of advancements in head and neck imaging on the diagnosis and treatment of patients with head and neck squamous cell carcinoma have been insufficiently explored:  

  • What clinical parameters should be considered when recommending surgical or non-surgical treatment concepts?   
  • What clinical parameters influence the choice of a surgical approach if surgical treatment is recommended?
  • What functional impairments or quality of life are to be expected from surgical and non-surgical treatment concepts?
  • Can advancements in extracranial stereotactic radiation or immunotherapy extend the boundaries of curatively intended treatment concepts in previously palliative treatment settings?

This Special Issue will highlight the role of advancements in head and neck imaging on the diagnosis and treatment of head and neck squamous cell carcinoma. This Special Issue aims to cover clinical aspects that advance our understanding of how advancements in head and neck imaging influence the diagnosis and treatment of head and neck squamous cell carcinoma.

Dr. Daniel Dejaco
Dr. Wolfgang Freysinger
Guest Editors

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Keywords

  • head and neck squamous cell carcinoma
  • surgical treatment
  • extracranial stereotactic body radiotherapy
  • tumor volume
  • cervical lymph nodes classification
  • contrast enhanced computed tomography scans
  • ultrasound imaging
  • positron emission tomography
  • ultrasound imaging
  • radiomics
  • artificial intelligence
  • functional outcome
  • quality of life

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Published Papers (1 paper)

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Research

11 pages, 731 KiB  
Article
The Diagnostic Performance of Multiparametric Ultrasound in the Qualitative Assessment of Inconclusive Cervical Lymph Nodes
by Katharina Margherita Wakonig, Steffen Dommerich, Thomas Fischer, Philipp Arens, Bernd Hamm, Heidi Olze and Markus Herbert Lerchbaumer
Cancers 2023, 15(20), 5035; https://doi.org/10.3390/cancers15205035 - 18 Oct 2023
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Abstract
Background: Enlarged cervical lymph nodes (CLNs) can result from infection or malignancies, and a definitive diagnosis requires histological examination. Ultrasound (US) remains the first-line imaging modality for detection, and new US techniques may improve characterization. The aim of our study was to investigate [...] Read more.
Background: Enlarged cervical lymph nodes (CLNs) can result from infection or malignancies, and a definitive diagnosis requires histological examination. Ultrasound (US) remains the first-line imaging modality for detection, and new US techniques may improve characterization. The aim of our study was to investigate whether the qualitative assessment of multiparametric US (mpUS) can improve diagnostic performance in the differentiation of benign and malignant CLNs. Methods: 107 CLNs in 105 patients were examined by preoperative mpUS consisting of B-mode US, color-coded duplex sonography (CCDS), shear wave elastography (SWE) and contrast-enhanced US (CEUS). US images were evaluated in consensus by two experienced US operators. Histopathological examination was used as reference standard. Results: SWE and CEUS combined showed the highest overall diagnostic performance (91% sensitivity, 77% specificity, 87% positive predictive value (PPV), 83% negative predictive value (NPV), 90% accuracy, χ2 (1) = 51.485, p < 0.001) compared to B-mode US and CCDS (87% sensitivity, 44% specificity, 73% PPV, 65% NPV, 73% accuracy χ2 (1) = 12.415, p < 0.001). In terms of individual techniques, SWE had higher specificity than B-mode and CCDS (71% sensitivity, 90% specificity, 92% PPV, 64% NPV, 78% accuracy, χ2 (1) = 36.115, p < 0.001), while qualitative CEUS showed the best diagnostic performance of all investigated US techniques (93% sensitivity, 85% specificity, 91% PPV, 87% NPV, 90% accuracy, χ2 (1) = 13.219, p < 0.001). Perfusion patterns, homogeneity, presence of necrosis, and malignancy differed significantly between malignant and benign CLNs (p < 0.001). Conclusions: SWE and CEUS can facilitate the differentiation of inconclusive CLNs when performed to supplement B-mode US and CCDS. MpUS may thus aid the decision between surgery and a watch-and-scan strategy in enlarged CLNs. Full article
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