The Role of Alternative Splicing in Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 5757
Special Issue Editor
2. Department of Oncology, Institute of Health Research INCLIVA, 46010 Valencia, Spain
Interests: alternative TSSs; alternative polyadenylation; mechanisms of RNA splicing; mRNA and protein isoforms; spliceosome; aberrant splicing; hRNPs; exon skipping; intron retention; spliceosomal diseases
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Special Issue Information
Dear Colleagues,
Most eukaryotic structural genes contain several exons interspersed with introns. Among other mechanisms, the maturation of primary transcripts involves splicing, which most often results in the removal of introns to yield mature mRNA. Splicing of pre-mRNA is a very intricate mechanism that, in most cases, may be developed in several alternative ways. Some exons may be skipped and some introns may also be retained. In this way, alternative splicing may give rise to several mature mRNAs from a single structural gene, which may, in turn, be translated to yield several protein isoforms. The importance of alternative splicing transcends the academic interest because it is very common that the several mRNA or protein isoforms arising from a single gene possess different and even opposed functions. The use of alternative transcription start or termination sites further contributes to the multiplicity of isoforms.
Since the original discovery in 1994 that the canonical isoform of the FAS gene bound to the mitochondrial membrane is pro-apoptotic, while a soluble isoform is anti-apoptotic, many examples of alternative splicing have been found in which both oncogenic and suppressor isoforms may be produced from the same gene. Aberrant splicing may, therefore, result in oncogenicity in otherwise normal tissue. Due to these circumstances, a great interest in the relationships between alternative splicing and cancer has arisen in the last few years.
I am pleased to invite you to contribute to this Special Issue of Cancers, which tries to gather relevant papers supporting the increasing importance of those relationships. Both reviews and original manuscripts on mechanisms of alternative splicing, detection and analysis of isoforms, their value as diagnostic and/or prognostic factors, and splicing-related therapeutic approaches will be welcome. We hope that both basic and clinical oncologists will be interested in this exciting field of cancer research.
We are looking forward to receiving your contributions.
Prof. Dr. Luis Franco
Guest Editor
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Keywords
- chromatin
- histones
- gene transcription
- epigenetics
- alternative splicing
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