The Role of the Vasculature in Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 7576
Special Issue Editor
Interests: endothelial cells; senescence; microRNA; vascular normalisation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The vasculature of solid cancers is both structurally and functionally abnormal. These abnormalities contribute to the hypoxic microenvironment, changes in the extracellular matrix, and to the immune cell composition within the tumour. Immunotherapy is improving our ability to treat many cancers. However, the underlying necessity of successful immunotherapy is the infiltration of appropriate immune subsets into the tumour. This Special Edition will focus on improving our understanding of the vascular control of immune cell infiltration into tumours.
Key areas (but not limited to these):
Immune–vascular cross-talk
Structure and function of tumour-associated vessels/implication for immune infiltration
Novel vascular therapeutic targets
Vascular control of leucocyte subsets
Circulating biomarkers to monitor changes in the vasculature
How can we improve normalisation in hard-to-treat tumours?
Vascular mimicry
Prof. Jennifer Gamble
Guest Editor
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Keywords
- normalization
- vasculature
- immunotherapy
- immune subsets
- endothelial cells
- pericytes
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