Epidemiology and Prevention of Gastric Cancer

Dear Colleagues, 

This Special Issue aims to provide new insight into gastric cancer epidemiology and prevention. The continuous update of the estimates of incidence and mortality from gastric cancer is fundamental to describing the temporal trends of this disease and predicting future changes in its burden. Asian and less developed countries register the highest gastric cancer rates, given the strict relationship between lifestyle and socioeconomic factors and this neoplasm. The investigation of the risk factors underlying the disease, also distinguishing its anatomical and histological subsites, represents one of the major objectives of improving gastric cancer control policies. While Helicobacter pylori (Hp) remains a major cause of gastric cancer, mainly related to the non-cardia type and to the mucosa-associated lymphoid tissue of the stomach, several other modifiable factors are accounted as known risk factors. Evidence on many dietary factors and infectious agents other than Hp is still inconsistent, and little is known about the genes underlying gastric cancer risk. Furthermore, gastric cancer is connoted by high socioeconomic disparities, which also impact the difficult management of its outcome, which is often characterized by poor survival.Despite being largely preventable, there is no standardized program for its prevention, while some screening interventions have been implemented in high-risk countries. The Maastricht VI guidelines, which have been recently published, are cautious in recommendations around Hp management. Further research effort is required to clarify important features of gastric cancer and its subtypes and to define the cost-effectiveness of different potential approaches for its prevention.

Macroareas:

• Interactions between risk factors;
• Disparities;
• Genetics and GxE interactions;
• Increasing cardia cancer;
• Hp screening;
• AF of GC attributable to different risk factors;
• Hp strains;
• Water source; 
• Diet;
• Alcohol; 
• Microbiota;
• Studies from Africa;
• Primary prevention (diet supplementation, salt reduction);
• Endoscopic screening;
• Biomarkers.

Prof. Dr. Paolo Boffetta
Dr. Giulia Collatuzzo
Dr. Nuno Lunet
Guest Editors

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