Esophageal Cancer: Incidence, Risk Factors, and Early Diagnosis

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 2297

Special Issue Editor


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Guest Editor
1. Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, 17176 Stockholm, Sweden
2. School of Public Health, Fujian Medical University, Fuzhou 350001, China
Interests: epidemiology of esophageal cancer

Special Issue Information

Dear Colleagues,

Esophageal cancer is one of the leading causes of cancer-related deaths, causing over 400,000 deaths globally each year. The two main histological subtypes of esophageal cancer, squamous cell carcinoma and adenocarcinoma, differ greatly in distribution and risk factor profiles. The etiology of esophageal cancer is not completely understood. Esophageal cancer is featured by a poor prognosis, and tumor stage at diagnosis is the strongest prognostic factor. Detection at an early stage may improve prognosis, but unselected endoscopic screening or surveillance is not justified in the general population. Risk prediction models have shown the potential to identify selected high-risk individuals for targeted prevention and early detection, but such models need to be further refined and validated, and their clinical utility remains to be carefully evaluated.

The aim of this Special Issue is to provide epidemiologists, clinicians and public health professionals with an overview of the epidemiology and prevention of esophageal cancer, with a focus on updated evidence from public health and clinical epidemiological research from different parts of the world.

Dr. Shaohua Xie
Guest Editor

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Keywords

  • epidemiology
  • risk factor
  • etiology
  • early detection
  • risk prediction

Published Papers (1 paper)

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Review

24 pages, 1123 KiB  
Review
Overview of Risk Factors for Esophageal Squamous Cell Carcinoma in China
by Erica Conway, Haisheng Wu and Linwei Tian
Cancers 2023, 15(23), 5604; https://doi.org/10.3390/cancers15235604 - 27 Nov 2023
Cited by 3 | Viewed by 1803
Abstract
(1) Background: China has the highest esophageal squamous cell carcinoma (ESCC) incidence areas in the world, with some areas of incidence over 100 per 100,000. Despite extensive public health efforts, its etiology is still poorly understood. This study aims to review and summarize [...] Read more.
(1) Background: China has the highest esophageal squamous cell carcinoma (ESCC) incidence areas in the world, with some areas of incidence over 100 per 100,000. Despite extensive public health efforts, its etiology is still poorly understood. This study aims to review and summarize past research into potential etiologic factors for ESCC in China. (2) Methods: Relevant observational and intervention studies were systematically extracted from four databases using key terms, reviewed using Rayyan software, and summarized into Excel tables. (3) Results: Among the 207 studies included in this review, 129 studies were focused on genetic etiologic factors, followed by 22 studies focused on dietary-related factors, 19 studies focused on HPV-related factors, and 37 studies focused on other factors. (4) Conclusions: ESCC in China involves a variety of factors including genetic variations, gene–environment interactions, dietary factors like alcohol, tobacco use, pickled vegetables, and salted meat, dietary behavior such as hot food/drink consumption, infections like HPV, poor oral health, gastric atrophy, and socioeconomic factors. Public health measures should prioritize genetic screening for relevant polymorphisms, conduct comprehensive investigations into environmental, dietary, and HPV influences, enhance oral health education, and consider socioeconomic factors overall as integral strategies to reduce ESCC in high-risk areas of China. Full article
(This article belongs to the Special Issue Esophageal Cancer: Incidence, Risk Factors, and Early Diagnosis)
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