The Role of Adipocyte Crosstalk in the Tumor Microenvironment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4095

Special Issue Editors


E-Mail Website
Guest Editor
Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66103, USA
Interests: adipocyte; cancer; pancreas; obesity; adiponectin; leptin; SHP-2; adipokine; microenvironment; MAPK

E-Mail Website
Guest Editor
The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Interests: pancreatic diseases; pancreatic cancer; pancreatitis; early detection; obesity; diabetes

Special Issue Information

Dear Colleagues,

We are assembling a special issue in the journal Cancers to focus on highlighting work related to pathways associated with the adipose tissue and its crosstalk in the tumor microenvironment. Tumor initiation and progression are influenced by multiple factors related to systemic and intercellular communication from other tissues. For instance, adipocytes within the adipose tissue can affect tumor intercellular communications and contribute to signaling changes that impact the behavior of various tumor types. In particular, adipocytes are capable of influencing multiple hallmarks of cancer cells like proliferation, invasion, cell death, angiogenesis, metabolism, and immunity. A wide field of expertise will be required to build a comprehensive analysis of adipose tissue-tumor crosstalk. The purpose of this special issue it to highlight advances in the understanding of molecular mechanisms that mediate adipose-tumor interactions and to uncover novel pathways that will benefit and advance the field of obesity-associated tumors. Additionally, adipose-stromal interactions with fibroblasts, immune cells, and endothelial cells will also be covered in the context of the tumor microenvironment. We anticipate this issue will expand our understanding of adipose tissue communication and further the development of effective therapeutics to subvert pro-tumorigenic mediators.

Dr. Michael VanSaun
Dr. Zobeida Cruz-Monserrate
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipocyte
  • adipose
  • tumor microenvironment
  • crosstalk
  • stroma
  • lipid
  • adipokine
  • fatty acid
  • cachexia
  • wasting
  • obesity
  • cancer

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

16 pages, 3029 KiB  
Review
Emerging Roles of Lipophagy in Cancer Metastasis
by Haimeng Yin, Ying Shan, Tian Xia, Yan Ji, Ling Yuan, Yiwen You and Bo You
Cancers 2022, 14(18), 4526; https://doi.org/10.3390/cancers14184526 - 19 Sep 2022
Cited by 2 | Viewed by 3438
Abstract
Obesity is a prominent risk factor for certain types of tumor progression. Adipocytes within tumor stroma contribute to reshaping tumor microenvironment (TME) and the metabolism and metastasis of tumors through the production of cytokines and adipokines. However, the crosstalk between adipocytes and tumor [...] Read more.
Obesity is a prominent risk factor for certain types of tumor progression. Adipocytes within tumor stroma contribute to reshaping tumor microenvironment (TME) and the metabolism and metastasis of tumors through the production of cytokines and adipokines. However, the crosstalk between adipocytes and tumor cells remains a major gap in this field. Known as a subtype of selective autophagy, lipophagy is thought to contribute to lipid metabolism by breaking down intracellular lipid droplets (LDs) and generating free fatty acids (FAs). The metastatic potential of cancer cells closely correlates with the lipid degradation mechanisms, which are required for energy generation, signal transduction, and biosynthesis of membranes. Here, we discuss the recent advance in the understanding of lipophagy with tumor lipid metabolism and review current studies on the roles of lipoghagy in the metastasis of certain human malignancies. Additionally, the novel candidate drugs targeting lipophagy are integrated for effective treatment strategies. Full article
(This article belongs to the Special Issue The Role of Adipocyte Crosstalk in the Tumor Microenvironment)
Show Figures

Figure 1

Back to TopTop