Current Management of Castration-Resistant Prostate Cancer (CRPC)
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 20093
Special Issue Editors
Interests: genitourinary cancers; serum biomarkers; prognostic and predictive biomarkers; castration-resistant prostate cancer; anti-hormonal therapy; immunotherapy; clinical trials; liquid biopsy; drug development
Special Issue Information
Dear Colleagues,
In recent years, the treatment of castration-resistant prostate cancer has witnessed dramatic advances. Currently, the inhibition of androgen receptor signaling, chemotherapy, and radioligand therapies in various sequences are the mainstay of therapy. However, sooner or later, primary or secondary resistance against any given therapy inevitably occurs. Reasons for this include sustained proliferative androgen receptor signaling, activating point mutations of the androgen receptor, alternative splicing of the androgen receptor, cell cycle activation, evading apoptosis, inducing angiogenesis, activating invasion and metastasis, defective DNA-repair machinery, evasion of immune control, and many more. All of these occur in the context of chronic inflammation and genomic instability. Castration-resistant prostate cancer is still uncurable, and accounts for nearly all prostate cancer-related deaths. Understanding the genetic and biological mechanisms leading to therapy resistance and sustaining progression is crucial to achieving further advances in the sequencing of available drugs and management of castration-resistant prostate cancer in general. Any experimental and clinical work potentially relevant to this Special Issue will be carefully considered for inclusion.
Prof. Dr. Martin Bögemann
Prof. Dr. Tilman Todenhöfer
Guest Editors
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Keywords
- therapy sequencing
- outcome
- response
- predictive biomarkers
- prognostic biomarkers
- treatment resistance
- androgen receptor
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