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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Perspectives in Lung Cancer: From Technique to Outcome

edited by Takahiro Homma and Hyun Koo Kim

submission deadline 30 Jun 2026 | Viewed by 627 | Submission Open

Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery

(This special issue belongs to the Section Cancer Therapy)

Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma

edited by

Vera Ulrike Bacher

and

Ashwini K. Yenamandra

submission deadline 30 Jun 2026 | Viewed by 617 | Submission Open

Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment

(This special issue belongs to the Section Cancer Therapy)

Recent Updates on Treatment of Uveal Melanoma

edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr

submission deadline 30 Jun 2026 | Viewed by 612 | Submission Open

Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research

(This special issue belongs to the Section Cancer Therapy)

Advances in the Pathogenesis of Hematopoietic Neoplasms

edited by

Raju K. Pillai

and

Steven T. Rosen

submission deadline 30 Jun 2026 | Viewed by 608 | Submission Open

Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Actual Aspects of Prostate Cancer Treatment—an Interdisciplinary Approach (Third Edition)

edited by

Hans Christiansen

submission deadline 30 Jun 2026 | 1 articles | Viewed by 576 | Submission Open

Keywords: prostate cancer; surgery; radiotherapy; hypofractionation; interdisciplinarity; nuclear medicine; PSMA

(This special issue belongs to the Section Cancer Therapy)

Research Challenges in Adolescent and Young Adult Cancer

edited by

Lorna A. Fern

and Jeremy Lewin

submission deadline 30 Jun 2026 | Viewed by 490 | Submission Open

Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers

(This special issue belongs to the Section Pediatric Oncology)

Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy

edited by

Luca Tamagnone

and Roberta Mastrantonio

submission deadline 30 Jun 2026 | Viewed by 455 | Submission Open

Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism

(This special issue belongs to the Section Tumor Microenvironment)

Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)

edited by

Francis Levi

Pasquale F. Innominato

and Esra Tasali

submission deadline 30 Jun 2026 | Viewed by 455 | Submission Open

Keywords: drug development and chronotherapy; chemotherapy; immunotherapy; targeted agents; radiotherapy; surgery; circadian host or tumor biomarkers; electronic patient-reported outcomes; circadian rhythms and sleep; sex- and age specificities; clinical trial designs; mathematical models and artificial intelligence; digital healthcare; telemedicine and logistics

(This special issue belongs to the Section Cancer Therapy)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 30 Jun 2026 | Viewed by 414 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by

Nicolas Nassar

submission deadline 30 Jun 2026 | Viewed by 407 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment

edited by

Maria Georgiadou

Eirini Velliou

and

Eugenia Roupakia

submission deadline 30 Jun 2026 | Viewed by 368 | Submission Open

Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies

(This special issue belongs to the Section Cancer Therapy)

Advancements in Multimodal Imaging Techniques for Brain Tumor Diagnosis and Treatment

edited by

Keisuke Miyake

submission deadline 30 Jun 2026 | Viewed by 362 | Submission Open

Keywords: multimodal imaging; brain tumors; PET; advanced MRI; imaging biomarkers; glioblastoma; image-guided surgery; tumor infiltration; precision neuro-oncology

(This special issue belongs to the Section Methods and Technologies Development)

Human Carcinogens—New Insights from Occupational Exposure

edited by

Enrico Oddone

and

Roberta Pernetti

submission deadline 30 Jun 2026 | Viewed by 360 | Submission Open

Keywords: occupational carcinogens; chemical exposure; cancer prevention; artificial intelligence (AI); workplace health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy

edited by

Maria Francesca Baietti

submission deadline 30 Jun 2026 | Viewed by 346 | Submission Open

Keywords: arginine; cancer; therapy; immunotherapy; metabolism

(This special issue belongs to the Section Cancer Therapy)

Cancer and Aging: Challenges in Geriatric Cancer Survivorship

edited by

Ruth Parks

and Dana E. Giza

submission deadline 30 Jun 2026 | Viewed by 340 | Submission Open

Keywords: geriatric oncology; survivorship; advance care planning; quality of life; de-escalation of treatment

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pharmacokinetics in Cancer Treatment

edited by Jing Li

submission deadline 30 Jun 2026 | Viewed by 335 | Submission Open

Keywords: pharmacokinetics (PK); pharmacodynamics (PD); population PK/PD modeling; PBPK modeling; clinical pharmacology; personalized oncology; cancer treatment; pharmacogenetics; molecular pharmacology

(This special issue belongs to the Section Cancer Drug Development)

Tumor Microenvironment of Thyroid Carcinoma

edited by

Juan Carlos Jaume

submission deadline 30 Jun 2026 | Viewed by 330 | Submission Open

Keywords: thyroid cancer; tumor immune microenvironment (TIME); double-negative T cells (DN T cells); tumor-associated macrophages (TAMs)

(This special issue belongs to the Section Tumor Microenvironment)

Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis

edited by

Nan Hu

submission deadline 30 Jun 2026 | Viewed by 321 | Submission Open

Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Pediatric Cancers: Advances and Emerging Therapeutic Strategies

edited by

Saurabh Agarwal

submission deadline 30 Jun 2026 | Viewed by 292 | Submission Open

Keywords: pediatric cancer; immunotherapy; tumorigenesis; metastasis; relapse; small molecule inhibitors; therapeutics; chemotherapy; cell signaling; epigenetics

(This special issue belongs to the Section Pediatric Oncology)

Modern Radiation Oncology: Predictions, Prognosis and Survivorship

edited by

Victor H. F. Lee

and

Shing Yau Tam

submission deadline 30 Jun 2026 | Viewed by 283 | Submission Open

Keywords: radiation oncology; predictive modeling; radiomics; survivorship; prognosis

Tumor Microenvironment (TME): Cellular and Molecular Interactions

edited by

Mauricio Retamal

submission deadline 30 Jun 2026 | Viewed by 282 | Submission Open

Keywords: cancer stem cells; hypoxia; connexins; tumor microenvironment; extracellular ATP; immune cells; extracellular acidification; extracellular matrix; extracellular vesicles

(This special issue belongs to the Section Tumor Microenvironment)

Emerging Molecular Mechanisms of Cancer Metastasis

edited by David Qualtrough,

James Robson

and

Daniel Turnham

submission deadline 30 Jun 2026 | Viewed by 281 | Submission Open

Keywords: metastasis; invasion; signalling; tumour microenvironment; hallmarks of cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Nanocarriers in Cancer Therapy

edited by

Wenyi Gu

submission deadline 30 Jun 2026 | Viewed by 280 | Submission Open

Keywords: nanoparticles; cancer therapy; anticancer drug delivery

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Clinical Treatment of Pancreatic Cancers

edited by

Alberto Brolese

submission deadline 30 Jun 2026 | Viewed by 280 | Submission Open

Keywords: pancreatic cancer; PDAC; neoadjuvant chemotherapy; neuroendocrine tumors; pNET; pancreatic cystic disease; IPMN; pancreatic oligometastases

(This special issue belongs to the Section Clinical Research of Cancer)

Breast Cancer Evolution—Insights from Single-Cell Genomics

edited by

Cynthia Ma

submission deadline 30 Jun 2026 | Viewed by 274 | Submission Open

Keywords: single-cell genomics; tumor evolution; intratumoral heterogeneity; lineage plasticity; therapy resistance; spatial transcriptomics; tumor microenvironment; clonal dynamics; multi-omics profiling

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Cancer Cytopathology

edited by Sanhong Yu and Guoping Cai

submission deadline 30 Jun 2026 | Viewed by 270 | Submission Open

Keywords: cancer cytopathology; cyto-histology correlation; molecular studies; artificial intelligence

(This special issue belongs to the Section Cancer Pathophysiology)

Molecular Mechanisms and Clonal Evolution of Recurrent Hepatocellular Carcinoma

edited by

Xin Zheng

submission deadline 30 Jun 2026 | Viewed by 269 | Submission Open

Keywords: recurrent hepatocellular carcinoma; molecular mechanisms; clonal evolution; multi-omics; tumor heterogeneity; tumor microenvironment; recurrence origin; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Insights into Mechanisms of Cancer-Associated Thrombosis: 2nd Edition

edited by Tom A J Mckinnon

submission deadline 30 Jun 2026 | Viewed by 259 | Submission Open

Keywords: cancer; thrombosis; venous; arterial

(This special issue belongs to the Section Molecular Cancer Biology)

Digital Pathology and AI for Tumor Microenvironment Mapping

edited by Mohammadreza Azimi

submission deadline 30 Jun 2026 | Viewed by 252 | Submission Open

Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning

Immunotherapy for Acute Lymphoblastic Leukemia: Novel Strategies and Clinical Perspectives

edited by Paola Minetto and

Francesco Grimaldi

submission deadline 30 Jun 2026 | Viewed by 235 | Submission Open

Keywords: immunotherapy; CAR T-cell therapy; bispecific antibodies; antibody– drug conjugates; treatment resistance; clinical perspectives; clinical trial in ALL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Gene Regulation and Immune Checkpoints in Cancer Immunotherapy: Mechanisms and Therapeutic Opportunities

edited by

Mohanraj Sadasivam

submission deadline 30 Jun 2026 | Viewed by 232 | Submission Open

Keywords: gene regulation; immune checkpoints; cancer immunotherapy; epigenetics; non-coding RNAs; tumor microenvironment; immune resistance; PD-1/PD-L1 pathway; chromatin remodeling; multi-omics profiling

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Innovations and Challenges in Clinical Trials and Translational Research in Hematologic Malignancies and Solid Tumors

edited by

Abdurraouf Mokhtar Mahmoud

and Clara Deambrogi

submission deadline 30 Jun 2026 | Viewed by 212 | Submission Open

Keywords: clinical trials; hematologic malignancies; solid tumors; translational research; precision medicine; biomarker-driven therapy; real-world evidence; investigator-initiated studies

Tumor Immune Microenvironment: Molecular Mechanisms and Signaling Pathways

edited by Hua Tian

submission deadline 30 Jun 2026 | Viewed by 209 | Submission Open

Keywords: tumor immune microenvironment; signaling pathways; immunotherapy; crosstalk

Artificial Intelligence Across the Head and Neck Cancer Care Continuum

edited by Jason Newman, William Albergotti,

Shaun A. Nguyen

Dauren Adilbay

, Alexandra Eva Kejner and Michael Bobian

submission deadline 30 Jun 2026 | Viewed by 207 | Submission Open

Keywords: artificial intelligence; head and neck cancer; diagnostic imaging; tumor staging; digital pathology; histopathologic evaluation; treatment planning; radiation therapy planning; treatment response assessment; functional outcomes; speech and swallowing outcomes; clinical decision support

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Insights into Drug Resistance in Cancer: 2nd Edition

edited by Yuqi Yang

submission deadline 30 Jun 2026 | Viewed by 200 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

Calcium-Linked Messaging in Cancer

edited by

Amantini Consuelo

submission deadline 30 Jun 2026 | Viewed by 198 | Submission Open

Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy

(This special issue belongs to the Section Tumor Microenvironment)

Cellular Immunotherapy for Leukemias—Advances, Limitations, and the Path Forward

edited by Lohith Gowda and Stuart E. Seropian

submission deadline 30 Jun 2026 | Viewed by 191 | Submission Open

Keywords: cellular therapy; cellular immunotherapy; leukemias

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Diagnosis and Therapy of Skin Cancers

edited by

Kelly Harms

submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open

Keywords: skin cancer; basal cell carcinoma; squamous cell carcinoma; melanoma; merkel cell carcinoma; dermatofibrosarcoma protuberans; atypical fibroxanthoma; extramammary Paget’ s disease; adnexal carcinoma; rare skin cancer

Advances in Diagnosis and Clinical Trials of Bladder Cancer

edited by Mutsuo Furihata

submission deadline 30 Jun 2026 | Viewed by 173 | Submission Open

Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence

New Implication in the Platelet–Cancer Interplay

edited by Lenard M. Lichtenberger

submission deadline 30 Jun 2026 | Viewed by 157 | Submission Open

Keywords: platelet; COX-1; aspirin; phosphatidylcholine; colorectal cancer; thrombocytosis

Reappearance of Dawn: CAR-T Restricts Glioblastoma

edited by

Qianxue Chen

submission deadline 30 Jun 2026 | Viewed by 150 | Submission Open

Keywords: CAR-T cell therapy; glioblastoma (GBM); immunotherapy; antigen escape; blood– brain barrier; immunosuppressive tumor microenvironment; clinical efficacy; toxicity; combination therapy; future strategies

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Diagnostics and Prognostics Tools for Prostate Cancer

edited by

Antonio Celia

, Tommaso Silvestri and Sara Riolo

submission deadline 30 Jun 2026 | Viewed by 141 | Submission Open

Keywords: prostate cancer; prostate biopsy; liquid biopsy; tissue biopsy; biomarkers; staging; risk stratification; prognostic tools

Advances in Therapeutic Strategies for Prostate Cancer

edited by Angelo Naselli and

Giacomo Maria Pirola

submission deadline 1 Jul 2026 | 5 articles | Viewed by 31784 | Submission Open

Keywords: immunotherapy; radiation therapy; hormone therapy; targeted therapies

(This special issue belongs to the Section Cancer Therapy)

Pediatric Brain Tumors: Symptoms, Diagnosis and Treatments

edited by Christian Ott and Julius Höhne

submission deadline 1 Jul 2026 | 3 articles | Viewed by 11316 | Submission Open

Keywords: MRI/CT scans; radiation therapy; chemotherapy; combined therapy

(This special issue belongs to the Section Cancer Therapy)

The Role of Radiotherapy, Immunotherapy and New Surgical Techniques in the Treatment of Lung Neoplasms

edited by

Elisa Meacci

submission deadline 1 Jul 2026 | 4 articles | Viewed by 10287 | Submission Open

Keywords: radiotherapy; immunotherapy; new surgical techniques; lung cancer

(This special issue belongs to the Section Cancer Therapy)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 1 Jul 2026 | 4 articles | Viewed by 9399 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Mediastinum—Pandora’s Box

edited by

Cesar A. Moran

submission deadline 1 Jul 2026 | 2 articles | Viewed by 3153 | Submission Open

Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors

Clinical Trials for Diffuse Large B-Cell Lymphomas (DLBCL)

edited by

Erel Joffe

submission deadline 1 Jul 2026 | 2 articles | Viewed by 2536 | Submission Open

Keywords: DLBCL; immunotherapy; drug combinations; elderly patients; ctDNA; biomarkers; radiotherapy; clinical trial management; artificial intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Oncogenetics of Colorectal Cancer (2nd Edition)

edited by

Muhammad Kibriya

and Marc Bissonnette

submission deadline 1 Jul 2026 | 1 articles | Viewed by 1171 | Submission Open

Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Treatment in Urothelial Cancer

edited by Muhammad Shamim Khan and Yasmin Abu-Ghanem

submission deadline 1 Jul 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: urothelial cancer; surgery; systemic anti cancer therapy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

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