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Clocks & Sleep
Special Issues
Updates in Narcolepsy and Related Disorders
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Updates in Narcolepsy and Related Disorders

A special issue of Clocks & Sleep (ISSN 2624-5175). This special issue belongs to the section "Disorders".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1179

Special Issue Editors

Dr. Hrayr P. Attarian

E-Mail Website
Guest Editor
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Interests: diagnosing and treating sleep disorders; narcolepsy; insomnia
Prof. Dr. Eun Yeon Joo

E-Mail Website
Co-Guest Editor
Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Interests: sleep disorders; epilepsy; seizure disorders; epilepsy surgery
Dr. Bharati Prasad

E-Mail Website
Co-Guest Editor
Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: sleep; chronic obstructive pulmonary disease; sleep apnea

Special Issue Information

Dear Colleagues,

The focus of this collection of articles is to highlight updates in the epidemiology, clinical presentations, and pathophysiology of narcolepsy and other primary hypersomnias.

This Special Issue aims to provide a platform for discussing the various challenges involved in diagnosing and treating narcolepsy, and related conditions, as well as recent updates on its pathophysiology and epidemiology.

In this Special Issue, original research articles, case reports, and reviews are welcome. Research areas may include, but are not limited to, the following:

  • Original research articles on primary hypersomnias and other related conditions;
  • Meta-analysis articles on hypersomnia features and therapeutics;
  • Perspective pieces and opinions, as well as commentary and narratives;
  • Case reports and case series on the topic of primary hypersomnias;
  • State-of-the-art reviews;
  • Systematic reviews.

Dr. Hrayr P. Attarian
Guest Editor

Prof. Dr. Eun Yeon Joo
Dr. Bharati Prasad
Co-Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clocks & Sleep is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • narcolepsy
  • idiopathic hypersomnia
  • cataplexy
  • periodic hypersomnia
  • sleep disorders

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 655 KiB  
Article
Sleep Patterns, Excessive Daytime Sleepiness, and Sleep Disturbance Among First Nations Children in Saskatchewan
by Chandima P. Karunanayake, Charlene Thompson, Meera J. Kachroo, Donna C. Rennie, Warren Seesequasis, Jeremy Seeseequasis, James A. Dosman, Mark Fenton, Vivian R. Ramsden, Malcolm King, Sylvia Abonyi, Shelley Kirychuk, Niels Koehncke and Punam Pahwa
Clocks & Sleep 2025, 7(2), 21; https://doi.org/10.3390/clockssleep7020021 - 25 Apr 2025
Abstract
Sleep is essential for maintaining both mental and physical well-being. It plays a critical role in the health and development of children. This study investigates sleep patterns and habits of First Nations children, the prevalence of sleep disturbances, and excessive daytime sleepiness (EDS), [...] Read more.
Sleep is essential for maintaining both mental and physical well-being. It plays a critical role in the health and development of children. This study investigates sleep patterns and habits of First Nations children, the prevalence of sleep disturbances, and excessive daytime sleepiness (EDS), along with the factors associated with EDS. Our 2024 First Nations Children Sleep Health Study assessed the sleep health of children aged 6 to 17 years living in a First Nation in Canada. Statistical analyses were performed using comparison tests and logistic regression models. A total of 78 children participated; 57.7% were boys. The average age of the participants was 10.49 years (SD = 3.53 years). On school days, children aged 6 to 9 years slept an average of one additional hour, while on weekends, they slept an extra 40 min compared to adolescents aged 10 to 17 years. Only 39.7% of the children (ages 6 to 17) slept alone in a room, with more than 80% of the children sharing a bed every night. Only 30.6% of the children aged 6 to 9 years and 7.2% of the adolescents aged 10 to 17 years adhered to the recommended maximum screen time of 2 h on school days. More than two-thirds of the children reported experiencing sleep disturbances. The prevalence of EDS was 19.7%. After adjusting for age and sex, it was determined that the children who snored loudly and those who did not sleep in their own beds were more likely to experience abnormally high levels of daytime sleepiness. A high proportion of children exceeded the recommended screen time, an important public health issue. Further, identifying sleep patterns among children will facilitate the diagnosis and treatment of disordered sleep. Full article
(This article belongs to the Special Issue Updates in Narcolepsy and Related Disorders)
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13 pages, 810 KiB  
Article
Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden
by Anna Giertz, Johan Mesterton, Tanja Jakobsson, Stephen Crawford, Somraj Ghosh and Anne-Marie Landtblom
Clocks & Sleep 2025, 7(1), 8; https://doi.org/10.3390/clockssleep7010008 - 19 Feb 2025
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Abstract
Background: Narcolepsy impacts both patients and society, yet there is limited data on its socioeconomic consequences. Methods: This retrospective longitudinal cohort study used pseudonymized patient-level data from Swedish registers and included narcolepsy patients from January 2015–December 2019 and age–sex matched controls. All patients [...] Read more.
Background: Narcolepsy impacts both patients and society, yet there is limited data on its socioeconomic consequences. Methods: This retrospective longitudinal cohort study used pseudonymized patient-level data from Swedish registers and included narcolepsy patients from January 2015–December 2019 and age–sex matched controls. All patients received an index date corresponding to their first narcolepsy diagnosis. Results: This study included 466 incident narcolepsy patients and 2330 matched controls. During the years studied, healthcare resource utilization was 2–5 times higher for incident narcolepsy patients compared to matched controls (p < 0.0001). Modafinil, stimulants, and antidepressants were prescribed more often to incident narcolepsy patients (p < 0.0001). Work productivity was significantly impacted, as incident narcolepsy patients took 7.0–10.5 more sick leave days than their matched controls (p < 0.0001) and had an average of 14.8 net days of disability leave (associated with indirect costs of EUR 1630) versus only 5.8 days among matched controls (EUR 638) during the year of the index (p = 0.027). After controlling for age, sex, and the Charlson comorbidity index, the odds of disability leave were 3.3 times higher in incident narcolepsy patients. Conclusions: This study provides evidence of the magnitude of the substantial societal economic burden due to narcolepsy in Sweden, evidenced by higher healthcare resource utilization and indirect costs. Full article
(This article belongs to the Special Issue Updates in Narcolepsy and Related Disorders)
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