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Current Oncology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Shaping the Future of Oncology: The Role of Generative AI in Clinical and Research Environments

edited by

Matthias May

, Emily Rinderknecht and Maximilian Haas

submission deadline 31 May 2026 | 7 articles | Viewed by 15923 | Submission Open

Keywords: generative AI in oncology; AI-driven cancer diagnostics; personalized cancer treatment; AI in clinical decision making; oncology research innovation; AI-assisted therapeutic strategies; cancer care technology; patient-centered AI tools and apps; translational oncology and AI; future of oncology; artificial intelligence

Innovative Therapeutic Strategies, Biomarkers, and Molecular Pathways in Gastrointestinal and Hepatobiliary Cancers

edited by Anwaar Saeed and

Azhar Saeed

submission deadline 31 May 2026 | 6 articles | Viewed by 15112 | Submission Open

Keywords: gastrointestinal cancers; hepatobiliary cancers; immunotherapy; targeted therapies; combination treatments; biomarkers; early diagnosis; prognosis; personalized medicine; molecular pathways; drug development targets

(This special issue belongs to the Section Gastrointestinal Oncology)

Feature Advancements in Section "Childhood, Adolescent and Young Adult Oncology"

edited by

Katrin Scheinemann

and Maria Otth

submission deadline 31 May 2026 | 2 articles | Viewed by 9172 | Submission Open

Keywords: childhood; adolescent and young adult cancer; survivorship; care models; transition; rehabilitation

(This special issue belongs to the Section Childhood, Adolescent and Young Adult Oncology)

Innovation in Gynecologic Cancer Surgery

edited by

Sarfraz Ahmad

submission deadline 31 May 2026 | 1 articles | Viewed by 1220 | Submission Open

Keywords: hysterectomy; gynecologic cancers; surgical oncology; minimally invasive surgery; fertility preservation; survivorship; cost-effectiveness

(This special issue belongs to the Section Gynecologic Oncology)

Surgical and Medical Management of Pancreatic Tumors: Indication, Techniques, and Prognostic Factors

edited by

Michele Tedeschi

, Antonella Delvecchio and Riccardo Memeo

submission deadline 31 May 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: pancreatic tumors; pancreatic surgery; neoadjuvant therapy; adjuvant therapy; short- and long-term outcomes; pancreatic diseases; surgical complication; recurrence rate; medical management; prognostic factors

(This special issue belongs to the Section Surgical Oncology)

Hypofractionated Radiotherapy for Prostate Cancer: Emerging Evidence and Clinical Practice

edited by

Hiromichi Ishiyama

submission deadline 31 May 2026 | Viewed by 399 | Submission Open

Keywords: hypofractionated radiotherapy; prostate cancer; ultra-hypofractionation; image-guided radiotherapy (IGRT); toxicity and outcomes; patient selection; radiotherapy techniques; combined modality therapy

(This special issue belongs to the Section Genitourinary Oncology)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 1 Jun 2026 | 2 articles | Viewed by 7206 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Gastrointestinal Oncology)

Recent Advances in Surgical Strategies for Managing Metastatic Colorectal Cancer

edited by Fabrizio D'Acapito and Marco Vaira

submission deadline 15 Jun 2026 | 3 articles | Viewed by 7317 | Submission Open

Keywords: metastatic colorectal cancer; liver metastases; parenchymal-sparing hepatectomy; staged hepatectomy; minimally invasive liver resection; cytoreductive surgery; HIPEC; PIPAC; peritoneal surface metastases; biomarker-based stratification

(This special issue belongs to the Section Gastrointestinal Oncology)

The Impact of Tumor Microenvironment on Therapeutic Resistance

edited by

Ziqing Chen

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1117 | Submission Open

Keywords: tumor microenvironment; therapeutic resistance; stromal– immune crosstalk

Advances in Novel Biomarkers for Kidney Cancer

edited by Brittney Hanerhoff Cotta

submission deadline 15 Jun 2026 | Viewed by 324 | Submission Open

Keywords: kidney cancer; renal cell carcinoma; biomarkers; genomics; risk stratification; prognosis

(This special issue belongs to the Section Genitourinary Oncology)

Surgery and Beyond: The Evolving Landscape of Glioma Management

edited by

Andrea Landi

submission deadline 15 Jun 2026 | Viewed by 282 | Submission Open

Keywords: neurosurgery; CNS tumor; surgery; therapeutic innovations; diagnostic innovations

(This special issue belongs to the Section Neuro-Oncology)

Targeted Molecular Therapeutics for Urologic Cancers: Advances, Emerging Strategies, and the Road Ahead

edited by

Carolina D'elia

submission deadline 15 Jun 2026 | Viewed by 270 | Submission Open

Keywords: urologic neoplasm; circRNA; molecular targeted therapy; therapeutic resistance; precision medicine

(This special issue belongs to the Section Genitourinary Oncology)

Recent Advances in Immune Checkpoint Inhibition and Antibody Drug Conjugates in Urothelial Carcinoma

edited by Qian Janie Qin

submission deadline 30 Jun 2026 | 3 articles | Viewed by 6807 | Submission Open

Keywords: immune checkpoint inhibition; antibody drug conjugates; urothelial carcinoma; therapeutic combinations; biomarkers; resistance mechanisms; treatment efficacy; cancer immunotherapy

(This special issue belongs to the Section Genitourinary Oncology)

BCMA-Directed CAR-T Therapy in Relapsed or Refractory Multiple Myeloma

edited by Al-Ola A. Abdallah

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5160 | Submission Open

Keywords: BCMA-directed CAR-T therapy; multiple myeloma; relapsed multiple myeloma; refractory multiple myeloma; B-cell maturation antigen; immunotherapy; treatment outcomes

(This special issue belongs to the Section Hematology)

Advances in PET/CT for Predicting Cancer Outcomes

edited by Ahmad Shariftabrizi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2032 | Submission Open

Keywords: FDG PET/CT; PSMA PET/CT; dotatate PET/CT; tumor heterogeneity; radiomics; CAR T-cell therapy; rare tumors; radiogenomics; immunotherapy; targeted therapy; PET physics; radiotracer metabolism

Prevention, Early Detection and Management of Skin Cancer

edited by

Patricia Tai

and

Kurian Joseph

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: skin cancer; dermato-oncology; cutaneous oncology; melanoma; non-melanomatous skin cancers; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma and other adnexal carcinomas; prevention and detection; treatment; biomarkers; immunotherapy and radiotherapy; precision medicine; UV radiation; surgery; targeted therapies

PD-1 and PD-L1 in Cancer Immunotherapy

edited by

Aleksandar Obradovic

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: PD-1; PD-L1; cancer immunotherapy; immune checkpoint inhibitors; resistance mechanisms; combination therapies

Therapeutic Advances in Cystectomy for Bladder Cancer

edited by Saum B. Ghodoussipour

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1193 | Submission Open

Keywords: bladder cancer; cystectomy; therapeutic advances; surgical techniques; personalized treatment

(This special issue belongs to the Section Genitourinary Oncology)

Recent Advancements in the Surgical Treatment of Brain Tumors—2nd Edition

edited by

Patrick Schuss

and Florian Gessler

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1190 | Submission Open

Keywords: brain tumors; intraoperative imaging; supramarginal resection; fluorescence-guided surgery; awake craniotomy; complication management; neurooncology; functional mapping; neuronavigation; intraoperative radiotherapy

(This special issue belongs to the Section Neuro-Oncology)

The Role of Targeted Therapy in Head and Neck Cancers

edited by

Rikki A.M. Brown

submission deadline 30 Jun 2026 | 1 articles | Viewed by 712 | Submission Open

Keywords: cancer; head and neck squamous cell carcinoma (HNSCC); targeted therapy; molecular drug targets; cancer biomarkers; personalized medicine; resistance mechanisms; combination therapies; translation oncology

(This special issue belongs to the Section Head and Neck Oncology)

Advancing Precision Medicine in Hepatocellular Carcinoma: The Comprehensive Role of Liquid Biopsy

edited by

Amy K. Kim

submission deadline 30 Jun 2026 | Viewed by 554 | Submission Open

Keywords: circulating tumor cells; hepatocellular carcinoma; precision medicine; tumor heterogeneity; early diagnosis; prognosis; personalized treatment

(This special issue belongs to the Section Cell Therapy)

Pain and Symptom Management in Cancer Patients

edited by Lynn R. Gauthier

submission deadline 30 Jun 2026 | Viewed by 527 | Submission Open

Keywords: cancer patients; pain management; symptom management; supportive care

Recent Advances in Artificial Intelligence-Based Approaches for Breast Cancer

edited by

Ashirbani Saha

submission deadline 30 Jun 2026 | Viewed by 509 | Submission Open

Keywords: breast cancer; artificial intelligence; multimodal data; breast cancer datasets; AI model validation; benchmarking; literature appraisal; explainable AI for breast cancer; personalized medicine; generative AI for breast cancer

(This special issue belongs to the Section Breast Cancer)

Targeting KRAS in Lung Cancer: Current Status and Future Directions

edited by Sally Lau

submission deadline 30 Jun 2026 | Viewed by 315 | Submission Open

Keywords: KRAS mutations; non-small cell lung cancer; targeted therapy; KRAS G12C inhibitors; translational research; combination therapy; clinical outcomes

(This special issue belongs to the Section Thoracic Oncology)

From Innovation to Impact: Age-Adaptive Oncology for Just and Precision-Driven Care

edited by Tanyanika Phillips

submission deadline 30 Jun 2026 | Viewed by 301 | Submission Open

Keywords: age-adaptive; oncology; older adults; aging; cancer; precision medicine; biological aging; functional aging; accelerated aging; biomarkers; therapeutics

(This special issue belongs to the Section Palliative and Supportive Care)

Transforming Pancreatic Cancer Treatment: Innovations in Molecular Diagnostics and Treatment Advances

edited by Nicola Normanno,

Michele Zanoni

and

Ilario Giovanni Rapposelli

submission deadline 30 Jun 2026 | Viewed by 296 | Submission Open

Keywords: pancreatic cancer; liquid biopsy; organoids; therapy resistance; predictive biomarkers

(This special issue belongs to the Section Oncology Biomarkers)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by Nicolas N Nassar

submission deadline 30 Jun 2026 | Viewed by 260 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

Brain Metastases: Biomarkers, Diagnosis, Treatment, Prognosis and Survival

edited by Katarzyna Jerzak

submission deadline 30 Jun 2026 | Viewed by 248 | Submission Open

Keywords: brain metastases; biomarkers; diagnosis and imaging; targeted and immunotherapy; prognosis and survival

(This special issue belongs to the Section Neuro-Oncology)

Deep Insights into Acute Myeloid Leukemia: Molecular Targets and Evolving Treatment Paradigms

edited by

Serena Travaglini

submission deadline 30 Jun 2026 | Viewed by 246 | Submission Open

Keywords: acute myeloid leukemia (AML); molecular targets; targeted therapy; treatment resistance; precision medicine; immunotherapy; multi-omics; relapsed/refractory leukemia; therapeutic strategies

(This special issue belongs to the Section Hematology)

2nd Edition: Allogeneic Stem Cell Transplantation: Does the Conditioning Regimen Intensity Still Matter?

edited by Imran Ahmad

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: conditioning; preparative; regimen; allogeneic; hematopoietic; transplantation; myeloablative; nonmyeloablative; reduced

(This special issue belongs to the Section Hematology)

Molecular Integrative Genomics in Cancer

edited by

Muhammad Kibriya

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2721 | Submission Open

Keywords: somatic mutation; cytogenetic abnormality; amplification; deletion; gene fusion; MSI; methylation; liquid biopsy; cell-free DNA; gene– environment interaction; targeted therapy; precision medicine

Combined Therapies for Hepatocellular Carcinoma

edited by

Hooman Yarmohammadi

submission deadline 20 Jul 2026 | 4 articles | Viewed by 13983 | Submission Open

Keywords: hepatocellular carcinoma; combined therapies; immunotherapy; locoregional therapy; external beam radiation

(This special issue belongs to the Section Gastrointestinal Oncology)

Unveiling the Economic Impact of Cancer Treatment

edited by

Stuart Peacock

submission deadline 20 Jul 2026 | Viewed by 353 | Submission Open

Keywords: financial toxicity; cost-effectiveness; health equity; cancer economics; value-based care; economic disparities; survi-vorship; policy interventions; global burden; healthcare access

(This special issue belongs to the Section Health Economics)

Thoracic Malignancies and Immunity: Advances, Challenges, and Future Directions of Immunotherapy

edited by Giacomo Cusumano

submission deadline 30 Jul 2026 | 2 articles | Viewed by 2330 | Submission Open

Keywords: lung cancer (NSCLC and SCLC); malignant pleural mesothelioma; immune checkpoint inhibitors; biomarkers (PD-L1; TMB; ctDNA); tumor microenvironment & immune evasion; combination therapies (chemo-IO; IO-IO; radiotherapy); neoadjuvant and adjuvant immunotherapy; immune-related adverse events (irAEs); resistance mechanisms & re-challenge; real-world evidence & translational research

(This special issue belongs to the Section Thoracic Oncology)

Routine Screening for Distress, Depression and Anxiety in Oncology: Where Are We Now?

edited by Daniel C. McFarland and Lee A. Kehoe

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4430 | Submission Open

Keywords: psychological distress; depression; anxiety; oncology; routine screening; cancer care; patient outcomes

(This special issue belongs to the Section Psychosocial Oncology)

Recent Advances in Breast Reconstruction Following Cancer

edited by

Jing Zhang

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1501 | Submission Open

Keywords: prepectoral implant-based reconstruction; post-reconstruction radiation; mastectomy pattern; non-abdominal autologous-based breast reconstruction; breast reconstruction complication; patient-reported outcome; breast sensation; fat grafting; enhanced recovery after surgery (ERAS) protocols; oncoplastic breast reconstruction; lymphatic reconstruction

(This special issue belongs to the Section Breast Cancer)

Innovations in the Clinical Research of Chronic Myeloid Leukemia: From Targeted Therapies to Allogeneic Stem Cell Transplantation

edited by Jeffrey H. Lipton

submission deadline 31 Jul 2026 | Viewed by 413 | Submission Open

Keywords: chronic myeloid leukemia; tyrosine kinase inhibitors; treatment resistance; allogeneic stem cell transplantation; stem cell persistence; treatment-free remission; targeted therapies

(This special issue belongs to the Section Hematology)

Advances in Interventional Radiology for Oncological Management

edited by Alex L. Wallace and

Merve Ozen

submission deadline 31 Jul 2026 | Viewed by 333 | Submission Open

Keywords: interventional oncology; tumor ablation; embolization; image-guided therapy; personalized medicine; translational research; cancer care

Contrast-Enhanced Imaging for Breast Cancer Detection and Management

edited by Enida Bufi,

Alejandro Martin Sanchez

, Matteo Sammarra and Angela Bucaro

submission deadline 31 Jul 2026 | Viewed by 312 | Submission Open

Keywords: contrast-enhanced mammography (CEM); breast cancer imaging; dense breast tissue; dual-energy mammography; radiomics; artificial intelligence; iodinated contrast medium

(This special issue belongs to the Section Breast Cancer)

Hope Amidst Challenges: Therapies for Relapsed/Refractory Multiple Myeloma

edited by

Martha L. Louzada

submission deadline 10 Aug 2026 | Viewed by 233 | Submission Open

Keywords: RRMM; quadruplet therapy; CART-cell; bispecific antibodies; antibody drug conjugates (ADC); minimal residual disease (MRD)

(This special issue belongs to the Section Hematology)

Surgical Advances in the Management of Gastrointestinal Cancers

edited by Boris Luis Gala-López

submission deadline 15 Aug 2026 | 3 articles | Viewed by 3613 | Submission Open

Keywords: gastrointestinal cancers; surgical innovation; multimodal therapy; precision oncology; minimally invasive surgery

(This special issue belongs to the Section Gastrointestinal Oncology)

Glioblastoma: Symptoms, Causes, Treatment and Prognosis

edited by Giuseppe Lombardi and Alberto Bosio

submission deadline 30 Aug 2026 | 3 articles | Viewed by 1925 | Submission Open

Keywords: glioblastoma; molecular biomarkers; targeted therapy; immunotherapy; imaging; tumor microenvironment; prognosis

(This special issue belongs to the Section Neuro-Oncology)

The Evolving Landscape of Precision Medicine in Radiation Oncology

edited by

Fernando Munoz

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6766 | Submission Open

Keywords: biomarkers; genomics; precision medicine; transcriptomics; radiotherapy response prediction

Patient-Reported Outcomes Including Health-Related Quality of Life in Cancer Clinical Trials

edited by Caroline Hamm

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1616 | Submission Open

Keywords: patient-reported outcomes; guidelines; health-related quality of life; clinical trials; ethical considerations; prognosis

(This special issue belongs to the Section Palliative and Supportive Care)

Advances in Endocrine Therapy for Breast Cancer

edited by

Sandeep Sehdev

, Arif Ali Awan and

Karen A. Gelmon

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1237 | Submission Open

Keywords: endocrine therapy; breast cancer; endocrine resistance; CDK 4/6 inhibitor; biomarkers; selective endocrine receptor degraders (SERDs)

(This special issue belongs to the Section Breast Cancer)

Advances in Implementation Science and Knowledge Mobilization for Cancer Control

edited by

Sarah Neil-Sztramko

submission deadline 31 Aug 2026 | Viewed by 497 | Submission Open

Keywords: evidence-based interventions; cancer control; cancer prevention; cancer treatment; survivorship; knowledge mobilization; implementation science

Radiation Therapy and Targeted Therapies for Pancreatic Cancer

edited by Aswin Abraham

submission deadline 31 Aug 2026 | Viewed by 330 | Submission Open

Keywords: pancreatic cancer; radiation; chemo-radiation; SBRT; patterns of failure; radiobiology; radiation techniques; cell signaling; immunotherapy and radiation; targeted therapies

(This special issue belongs to the Section Gastrointestinal Oncology)

Treatment of High-Grade Glioma

edited by Chiara Valentini and Silvia Chiesa

submission deadline 31 Aug 2026 | Viewed by 315 | Submission Open

Keywords: high-grade glioma; treatment; surgery; radiation therapy; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Neuro-Oncology)

Glioblastoma: The Emerging Challenges in Rapidly Evolving Social Changes

edited by Andrea Talacchi and Andrea Pace

submission deadline 31 Aug 2026 | Viewed by 265 | Submission Open

Keywords: glioblastoma; glioma; social determinants; prognostic factors; clinical pathways; lifestyle; economic determinants; frailty; area deprivation; brain neoplasm; overall survival

(This special issue belongs to the Section Neuro-Oncology)

Role of Inflammation in Cancer

edited by

Li Yang

submission deadline 31 Aug 2026 | Viewed by 133 | Submission Open

Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention

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