Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Advances in Diagnostic Pathology
share announcement

Advances in Diagnostic Pathology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 1 June 2024 | Viewed by 1759

Special Issue Editor

Prof. Dr. Sergejs Isajevs

E-Mail Website
Guest Editor
Faculty of Medicine, University of Latvia, LV-1004 Riga, Latvia
Interests: diagnostic pathology; tumour biomarkers; molecular pathology

Special Issue Information

Dear Colleagues,

This Special Issue collates state-of-the-art knowledge of modern advances in diagnostic pathology, focusing on tissue biomarkers and the diagnostic and molecular pathology of malignant tumours. This Special Issue provides a platform for the dissemination of key opinions and research from leaders in the field through the timely publication of papers covering the latest developments and advances in pathology. For this Special Issue, we welcome high-quality original research focusing on the latest advances in tissue diagnostics, tumour diagnostics, and tumour biomarkers, as well as novel molecular pathology techniques covering novel diagnostics tools and the identification of new therapeutic targets. Manuscripts from different areas of pathology and laboratory medicine are welcomed, especially novel tissue diagnostic advances, molecular pathology, breast pathology, and gynaecological pathology.

We encourage you to submit a manuscript for this forthcoming Special Issue.

Prof. Dr. Sergejs Isajevs
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostic pathology
  • molecular pathology
  • tumour biomarkers
  • laboratory medicine
  • breast pathology
  • gynaecological pathology

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

23 pages, 13411 KiB  
Article
Comparison of Tissue Factors in the Ontogenetic Aspects of Human Cholesteatoma
by Kristaps Dambergs, Gunta Sumeraga and Māra Pilmane
Diagnostics 2024, 14(6), 662; https://doi.org/10.3390/diagnostics14060662 - 21 Mar 2024
Viewed by 878
Abstract
Background: An acquired cholesteatoma is a benign but locally aggressive lesion in the middle ear. It is characterized by chronic inflammation and the destruction of surrounding bone. Therefore, the aim of this study was to compare defensins HβD-2 and HβD-4; pro- and anti-inflammatory [...] Read more.
Background: An acquired cholesteatoma is a benign but locally aggressive lesion in the middle ear. It is characterized by chronic inflammation and the destruction of surrounding bone. Therefore, the aim of this study was to compare defensins HβD-2 and HβD-4; pro- and anti-inflammatory cytokines IL-1α and IL-10; proliferation marker Ki-67; transcription factor NF-κβ; angiogenetic factor VEGF; Sonic hedgehog gene protein SHH; and remodeling factors MMP-2, MMP-9, TIMP-2, and TIMP-4 in adult and pediatric cholesteatoma tissue, and to compare these groups with control skin tissue. Methods: The study included 25 cholesteatoma tissue material samples from children, 25 from adults, and 7 deep external ear canal skin samples from cadavers. The tissues were stained immunohistochemically and evaluated using semi-quantitative methods. Nonparametric tests, such as the Kruskal–Wallis test and Spearman rank correlation, were used. Results: There were no statistically discernible differences between the adult and children groups when comparing the relative numbers of factor-positive cells. Conclusions: There are no histopathological differences between adult and children cholesteatoma tissues. Full article
(This article belongs to the Special Issue Advances in Diagnostic Pathology)
►▼ Show Figures

Figure 1

11 pages, 2017 KiB  
Article
Evaluation of Stability and Accuracy Compared to the Westergren Method of ESR Samples Analyzed at VES-MATIC 5
by Maria Lorubbio, Daniela Diamanti, Alessandro Ghiandai, Carolina Pieroni, Donatella Bonini, Massimiliano Pettinari, Gabriele Gorini, Stefania Bassi, Paola Meloni and Agostino Ognibene
Diagnostics 2024, 14(5), 557; https://doi.org/10.3390/diagnostics14050557 - 6 Mar 2024
Cited by 1 | Viewed by 679
Abstract
The Erythrocyte Sedimentation Rate (ESR) is a diagnostic estimator of systemic inflammation as a reflection of acute phase proteins circulating in the blood. The purpose of this manuscript is to evaluate the blood stability at room temperature (RT) and at 4 °C to [...] Read more.
The Erythrocyte Sedimentation Rate (ESR) is a diagnostic estimator of systemic inflammation as a reflection of acute phase proteins circulating in the blood. The purpose of this manuscript is to evaluate the blood stability at room temperature (RT) and at 4 °C to avoid ESR diagnostic errors, as well as the accuracy of the VES-MATIC 5 analyzer. The ESR stability evaluation at RT for 24 h (4 h “T1”, 6 h “T2”, 8 h “T3”, 10 h “T4”, 24 h “T5”) and at 4 °C (24 h, 36 h, 48 h) was carried out using 635 total samples, starting with T0 (2 h of venipuncture). For method comparison, 164 patients were analyzed using VES-MATIC 5 and then the Westergren reference method. The sample at RT is established by a significant gradual decrease in correlation R = 0.99 (T0 vs. T1), R = 0.97 (T0 vs. T2), R = 0.92 (T0 vs. T3), R = 0.87 (T0 vs. T4), and R = 0.40 (T0 vs. T5). The stability at 4 °C after 24 h, 36 h, and 48 h showed a regression of R = 0.99, R = 0.97, and R = 0.95, respectively. Therefore, ESR measurements on RT samples beyond 6 h after collection cannot be carried out, but the ESR can be measured until 36 h for samples stored at 4 °C. Moreover, the VES-MATIC 5 accuracy performance compared to the Westergren method (R = 0.96) is confirmed. Full article
(This article belongs to the Special Issue Advances in Diagnostic Pathology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop