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Diagnostics
Special Issues
New Trends in the Diagnosis of Gynecological and Obstetric Diseases
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New Trends in the Diagnosis of Gynecological and Obstetric Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 2107

Special Issue Editors

Prof. Dr. Razvan Socolov

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Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
Interests: prenatal diagnostic; ultrasound in obstetrics and gynecology; endoscopic gynecology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Laurentiu Pirtea

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş", Timişoara, Romania
Interests: gynaecological surgery; gynecologic oncology; hysterectomy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the diagnosis of obstetrical and gynecological pathologies, modern approaches must address several aspects that are mentioned below: 1. The need for a shorter time frame from diagnosis to therapy, which is a requirement not only in subspecialties like oncology but also in reproductive medicine, prenatal medicine, and, in general, across all fields of this specialty. 2. The ease of access for the general population, which has changed various algorithms from screening to diagnosis and should be primarily available in ambulatory settings. 3. The efficiency of modern medicine also implies the use of more accurate methods aimed at solving the issue of differential diagnosis very early in the therapeutic process. 4. The results must be presented in a form that allows for the rapid transmission of information both intra- and interdisciplinary. 5. The revolution in artificial intelligence creates new perspectives but also presents new challenges for clinicians and patients.With these issues in mind, we propose a Special Issue of Diagnostics that invites all those with relevant research and feedback on modern diagnostics in obstetrics and gynecology to participate in a large multidisciplinary forum focused on obstetrical and gynecological pathology.

Prof. Dr. Razvan Socolov
Prof. Dr. Laurentiu Pirtea
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstetrics and gynecology diagnostics
  • screening
  • artificial intelligence
  • test accuracy

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Published Papers (3 papers)

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14 pages, 692 KiB  
Article
Maternal and Perinatal Outcomes in Pregnant Women with Cancer: A Single-Center Retrospective Cohort Study
by Bruna Elias Parreira Lopes Ferraz, Roney César Signorini Filho, Lucas Ribeiro Borges Carvalho, Michelle Samora Almeida, Tatiana Carvalho de Souza Bonetti, Edward Araujo Júnior, Antonio Braga, Sue Yazaki Sun and Roberta Granese
Diagnostics 2025, 15(8), 1012; https://doi.org/10.3390/diagnostics15081012 - 16 Apr 2025
Viewed by 170
Abstract
Objective: The aim of our study was to evaluate maternal and perinatal outcomes in pregnant women diagnosed with cancer and treated at a single referral center in Brazil. Methods: This retrospective cohort study analyzed medical records from January 2008 to December 2020. Demographic, [...] Read more.
Objective: The aim of our study was to evaluate maternal and perinatal outcomes in pregnant women diagnosed with cancer and treated at a single referral center in Brazil. Methods: This retrospective cohort study analyzed medical records from January 2008 to December 2020. Demographic, clinical, obstetric, and tumor-related variables were assessed. Patients were divided into two groups: Group 1 (n = 28) included women diagnosed with cancer during pregnancy or up to one year postpartum, while Group 2 (n = 11) comprised those who became pregnant during cancer investigation or treatment. Results: The most prevalent cancers were breast (G1 = 11, G2 = 3), cervical (G1 = 10, G2 = 3), and hematologic (G1 = 2, G2 = 4). Treatment modalities included surgery (n = 11), chemotherapy (n = 21), and inadvertent radiotherapy in one case. Most newborns (n = 25) were delivered at term, with one miscarriage, one fetal death, and one neonatal death reported. Thirty-two newborns were appropriate for gestational age, and thirty-seven were discharged with their mothers. Preterm delivery was indicated for obstetric reasons in 61.5% of cases. Overall survival by cancer type was 54% for breast, 70% for cervical, and 100% for hematologic cancers. The total survival rate was 70.9%. Conclusions: Cervical cancer was the second most common type in this cohort. Most deliveries occurred at term, and newborns were adequate for gestational age. Despite cancer treatment during pregnancy, most neonates were discharged alongside their mothers. Full article
(This article belongs to the Special Issue New Trends in the Diagnosis of Gynecological and Obstetric Diseases)
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20 pages, 737 KiB  
Article
Intrauterine Adhesions and Asherman Syndrome: A Retrospective Dive into Predictive Risk Factors, Diagnosis, and Surgical Perspectives
by Loredana Maria Toma, Demetra Socolov, Daniela Matei, Sorana Anton, Raluca Balan, Emil Anton, Roxana Covali, Mihaela Tirnovanu, Handra Elicona, Theodor Pantilimonescu and Razvan Socolov
Diagnostics 2025, 15(8), 955; https://doi.org/10.3390/diagnostics15080955 - 9 Apr 2025
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Abstract
Background: Intrauterine adhesions (IUAs) or Asherman syndrome (AS) represent pathological conditions that affect the endometrium and significantly influence female fertility through a variety of mechanisms. This study aims to identify risk factors, explore pathophysiological mechanisms, diagnostic approaches, and assess how medical background [...] Read more.
Background: Intrauterine adhesions (IUAs) or Asherman syndrome (AS) represent pathological conditions that affect the endometrium and significantly influence female fertility through a variety of mechanisms. This study aims to identify risk factors, explore pathophysiological mechanisms, diagnostic approaches, and assess how medical background influence the development of these conditions. It also seeks to associate the severity of conditions with clinical outcomes, such as fertility, miscarriages, and menstrual cycle disorders, using American Fertility Society (AFS) scoring system. Materials and methods: This retrospective cohort study included 134 patients aged 18 to 45, who followed hysteroscopy between 2016 and 2024 at two hospitals in Iasi, focusing on those diagnosed with IUAs (102 patients) and AS (32 patients), based on hysteroscopic approach. The exclusions were based of factors like acute uterine bleeding, intrauterine device, obesity and other severe conditions. Results and discussions: Women over 35 years are more likely to develop these conditions due to prior gynaecological procedures which are often associated with fertility issues. Hysteroscopy is established as the gold standard for both diagnosis and treatment, intraoperative diagnosis representing 45.6 % of cases. Amenorrhea is a primary indicator in AS patients (OR = 26.19) and dysmenorrhea as a potential marker for IUAs (OR = 2.67). Patients with IUAs and primary infertility (82.9%) typically have an AFS score 1, corresponding to improved conception rates. Those with AS and primary infertility often present an AFS score 2 (54.5%); patients with AS and secondary infertility were linked to AFS score 3 (58.8%; p = 0.137). Although the incidence of miscarriages is comparable between the two groups, the timing differs: IUAs are predominantly associated with first trimester losses (64.9%), whereas AS is more commonly linked to second trimester miscarriages (45.5%; p = 0.001). Conclusions: The study highlights the necessity of a personalized approach in diagnosing and treating IUAs and AS, considering factors such as age, fertility index, and disease severity. The integration of hysteroscopic techniques with individualized treatment plans based on the patient’s unique medical profile is crucial for adequate management of IUAs and AS. Full article
(This article belongs to the Special Issue New Trends in the Diagnosis of Gynecological and Obstetric Diseases)
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13 pages, 13701 KiB  
Case Report
Case Report of Placenta Accreta Spectrum and Arteriovenous Malformations with Successful Preservation of Fertility After Birth
by Constantin-Cristian Vaduva, Laurentiu Dira, Sidonia Maria Sandulescu, Cristian Constantin, Elena Silvia Bernad, Dana Maria Albulescu, Mircea-Sebastian Serbanescu and Lidia Boldeanu
Diagnostics 2024, 14(22), 2538; https://doi.org/10.3390/diagnostics14222538 - 13 Nov 2024
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Abstract
Uterine arteriovenous malformations (UAVMs) that occur after birth are a rare cause of late postpartum hemorrhage. Acquired UAVMs usually occur in conjunction with pathology of the placenta. In the spectrum of placenta accreta (PAS), subinvolution of the placental bed plays an important role [...] Read more.
Uterine arteriovenous malformations (UAVMs) that occur after birth are a rare cause of late postpartum hemorrhage. Acquired UAVMs usually occur in conjunction with pathology of the placenta. In the spectrum of placenta accreta (PAS), subinvolution of the placental bed plays an important role in its pathophysiology. We present a case of UAVM in a pregnant woman with PAS who presented with marked metrorrhagia after delivery, which was treated with classical management. Then, 35 days later, she presented to the emergency room with severe metrorrhagia. As it was suspected that she had placental remnants, an instrumental uterine control was performed, but the bleeding persisted, requiring further uterine packing and blood administration. Later, uterine artery embolization was performed with good results. Color Doppler ultrasound, magnetic resonance imaging, and angiography were the methods with the greatest diagnostic value. The differential diagnosis was as complex as the treatment. We hypothesize that UAVM may develop from minimal residual PAS in this late postpartum period. Moreover, they may recover rapidly after local surgical ablation. Considering the clinical condition, hemodynamic status, and desire to preserve fertility, we were able to avoid a hysterectomy, which is often chosen in such cases of severe, life-threatening bleeding complications. Full article
(This article belongs to the Special Issue New Trends in the Diagnosis of Gynecological and Obstetric Diseases)
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