Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.0
Journals
Diagnostics
Special Issues
Advances in Diagnostics of Chronic Kidney Disease
share announcement

Advances in Diagnostics of Chronic Kidney Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1792

Special Issue Editors

Dr. Tomasz Gołębiowski

E-Mail Website
Guest Editor
Wroclaw Medical University, Department of Nephrology and Transplantation Medicine, Wrocław, Poland
Interests: nephrology; chronic kidney disease; hemodialysis; vascular access
Special Issues, Collections and Topics in MDPI journals
Dr. Andrzej Konieczny

E-Mail Website
Guest Editor
Wroclaw Medical University, Department of Nephrology and Transplantation Medicine, Wrocław, Poland
Interests: nephrology; primary glomerulonephritis; systemic vasculitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Diagnostics will be devoted to the latest advances in chronic kidney disease (CKD) diagnostics.

CKD in different stages affects approximately 12% of the world's population. Nowadays, diabetes and hypertension are among the leading causes of CKD.

Due to the constant increase in the total number of diabetic patients, the incidence of CKD caused by diabetic nephropathy and subsequently the number of patients with end-stage renal disease (ESRD) is expected to rise. Early diagnosis and treatment of diabetic nephropathy may have a crucial impact on disease progression.

Glomerulonephritis (GN) is, next to hypertension and diabetes, one of the leading causes of CKD. Both nephrotic and nephritic syndromes are clinical conditions, requiring extensive diagnostic workup, including laboratory tests, imaging studies and eventually renal biopsy, with additional tests and specialized stains. In many GN patients, electron microscopy and genotyping might be crucial to achieve final diagnosis. Innovative IT tools are increasingly used in clinical settings. For example, artificial intelligence (AI) may help with precise diagnosis due to its ability to combine multiple clinical and laboratory data.

Acute kidney injury (AKI) is frequently observed in elderly patients, following surgical and radiological procedures, involving the administration of radiocontrast, with potential progression to CKD. Urinary biochemical markers may be helpful in predicting the development and severity of AKI. Point of care testing methods are increasingly used in nephrology patients with unstable clinical conditions, but also to assess CKD complications including electrolyte and acid–base disorders.

Hemodialysis (HD) is a one of the main forms of renal replacement therapy (RTT) in ESRD. Anemia, electrolyte disturbances, metabolic bone disease and both dialysis fistula and catheter dysfunction are the basic HD complications requiring appropriate diagnostic tools. More and more uremic toxins are being discovered in patients with ESRD, which influence the prognosis of dialysis patients.

We invite scientists to submit articles presenting new achievements in chronic kidney disease. We look forward to your submission.

Dr. Tomasz Gołębiowski
Dr. Andrzej Konieczny
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • diabetic nephropathy
  • glomerulonephritis
  • acid–base disorders
  • uremic toxin
  • artificial intelligence
  • metabolic bone disease
  • vascular access
  • arteriovenous fistula
  • catheter
  • hemodialysis

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 825 KiB  
Article
Changes of Dissociative Properties of Hemoglobin in Patients with Chronic Kidney Disease
by Justyna Korus, Maria Wydro, Maciej Gołębiowski, Kornelia Krakowska, Paweł Poznański, Kinga Musiał, Andrzej Konieczny, Hanna Augustyniak-Bartosik, Jakub Stojanowski, Mariusz Andrzej Kusztal and Tomasz Gołębiowski
Diagnostics 2024, 14(12), 1219; https://doi.org/10.3390/diagnostics14121219 - 8 Jun 2024
Viewed by 631
Abstract
Background: The ability of hemoglobin to bind and dissociate oxygen is crucial in delivering oxygen to tissues and is influenced by a range of physiological states, compensatory mechanisms, and pathological conditions. This may be illustrated by the oxyhemoglobin dissociation curve (ODC). The [...] Read more.
Background: The ability of hemoglobin to bind and dissociate oxygen is crucial in delivering oxygen to tissues and is influenced by a range of physiological states, compensatory mechanisms, and pathological conditions. This may be illustrated by the oxyhemoglobin dissociation curve (ODC). The key parameter for evaluating the oxygen affinity to hemoglobin is p50. The aim of this study was to evaluate the impact of hemodialysis on p50 in a group of patients with chronic kidney disease (CKD). An additional goal was to assess the correlation between p50 and the parameters of erythropoiesis, point-of-care testing (POCT), and other laboratory parameters. Methods: One hundred and eighty patients (106 male, 74 female), mean age 62.5 ± 17 years, with CKD stage G4 and G5 were enrolled in this cross-sectional study. Patients were divided into two groups, including 65 hemodialysis (HD) patients and 115 patients not receiving dialysis (non-HD). During the standard procedure of arteriovenous fistula creation, blood samples from the artery (A) and the vein (V) were taken for POCT. The causes of CKD, as well as demographic and comorbidity data, were obtained from medical records and direct interviews. Results: The weekly dose of erythropoietin was higher in HD patients than in non-HD patients (4914 ± 2253 UI vs. 403 ± 798 UI, p < 0.01), but hemoglobin levels did not differ between these groups. In the group of non-HD patients, more advanced metabolic acidosis (MA) was found, compared to the group with HD. In arterial and venosus blood samples, the non-HD group had significantly lower pH, pCO2 and HCO3−. This group had a higher proportion of individuals with MA with HCO3− < 22 mmol/L (42% vs. 24%, p < 0.01). The absolute difference of p50 in arterial and venous blood was determined using the formula Δp50 = (p50-A) − (p50-V). Δp50 was significantly higher in the HD group in comparison to non-HD (0.08 ± 2.05 mmHg vs. −0.66 ± 1.93 mmHg, p = 0,02). There was a negative correlation between pH and the p50 value in arterial (pH-A vs. p50-A, r = −0.56, p < 0.01) and venous blood (pH-V vs. p50-V, r = −0.45, p < 0.01). In non-HD patients, hemoglobin levels correlated negatively with p50 (r = −0.29, p < 0.01), whereas no significant relation was found in HD patients. Conclusions: The ODC in pre-dialysis CKD (non-HD) patients is shifted to the right due to MA, and this is an additional factor influencing erythropoiesis. Hemodialysis restores the natural differences in hemoglobin’s dissociation characteristics in the arterial and venous circulation. Full article
(This article belongs to the Special Issue Advances in Diagnostics of Chronic Kidney Disease)
►▼ Show Figures

Figure 1

18 pages, 7376 KiB  
Article
Downregulation of Glycine N-Acyltransferase in Kidney Renal Clear Cell Carcinoma: A Bioinformatic-Based Screening
by Juan P. Muñoz and Gloria M. Calaf
Diagnostics 2023, 13(23), 3505; https://doi.org/10.3390/diagnostics13233505 - 22 Nov 2023
Viewed by 863
Abstract
Clear cell renal cell carcinoma (KIRC) is the most common subtype of renal cell carcinoma (RCC). This form of cancer is characterized by resistance to traditional therapies and an increased likelihood of metastasis. A major factor contributing to the pathogenesis of KIRC is [...] Read more.
Clear cell renal cell carcinoma (KIRC) is the most common subtype of renal cell carcinoma (RCC). This form of cancer is characterized by resistance to traditional therapies and an increased likelihood of metastasis. A major factor contributing to the pathogenesis of KIRC is the alteration of metabolic pathways. As kidney cancer is increasingly considered a metabolic disease, there is a growing need to understand the enzymes involved in the regulation of metabolism in tumorigenic cells. In this context, our research focused on glycine N-acyltransferase (GLYAT), an enzyme known to play a role in various metabolic diseases and cancer. Here, through a bioinformatic analysis of public databases, we performed a characterization of GLYAT expression levels in KIRC cases. Our goal is to evaluate whether GLYAT could serve as a compelling candidate for an in-depth study, given its pivotal role in metabolic regulation and previously established links to other malignancies. The analysis showed a marked decrease in GLYAT expression in all stages and grades of KIRC, regardless of mutation rates, suggesting an alternative mechanism of regulation along the tumor development. Additionally, we observed a hypomethylation in the GLYAT promoter region and a negative correlation between the expression of the GLYAT and the levels of cancer-associated fibroblasts. Finally, the data show a correlation between higher levels of GLYAT expression and better patient prognosis. In conclusion, this article underscores the potential of GLYAT as a diagnostic and prognostic marker in KIRC. Full article
(This article belongs to the Special Issue Advances in Diagnostics of Chronic Kidney Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop