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Diagnostics
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Updates on the Diagnosis and Management of Retinal Diseases
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Updates on the Diagnosis and Management of Retinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 883

Special Issue Editor

Dr. Antonio Yaghy

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Guest Editor
New England Eye Center, Boston, MA, USA
Interests: retinal diseases

Special Issue Information

Dear Colleagues,

The field of ophthalmology has witnessed monumental advancements in the year 2023, marking it as a pivotal period in the evolution of retinal disease diagnosis and management. In February, a significant milestone was achieved with the Food and Drug Administration (FDA)’s approval of pegcetacoplan, a pioneering therapeutic agent for the treatment of geographic atrophy. This approval, following decades of diligent research and clinical trials, symbolizes a promising horizon in the battle against advanced dry age-related macular degeneration. The path of innovation continued undeterred into September, when the prestigious 2023 Lasker–DeBakey Clinical Medical Research Award was awarded to a trio of visionaries for their seminal invention of optical coherence tomography (OCT). This invention has not only advanced ophthalmic diagnostics but has reshaped the landscape of retinal disease care. OCT, now an indispensable tool in retina clinics, has caused a paradigm shift, facilitating earlier and more accurate diagnoses, thus enabling timely and targeted interventions in managing a variety of retinal diseases, including diabetic retinopathy and age-related macular degeneration (AMD).

This Special Issue will feature the latest developments and challenges in the diagnosis and management of retinal diseases. The topics covered in this issue include, but are not limited to, the following:

  • The application of OCT and OCT angiography for the screening, diagnosis, and monitoring of retinal diseases.
  • The advances in the treatment of retinal diseases, including wet and dry AMD, diabetic retinopathy, and inherited retinal diseases.

We invite original research articles and reviews that highlight the current state of the art and future directions in the field of retinal diagnostics. We hope that this Special Issue will provide a valuable resource for clinicians, researchers, and patients interested in retinal diseases.

Dr. Antonio Yaghy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography (OCT)
  • optical coherence tomography angiography (OCTA)
  • wide-field imaging
  • retinal diseases
  • age-related macular degeneration
  • diabetic retinopathy
  • inherited retinal diseases
  • medical diagnosis
  • clinical trials

Published Papers (2 papers)

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19 pages, 3756 KiB  
Review
Updates on Treatment Modalities for Primary Rhegmatogenous Retinal Detachment Repair
by Sofija Davidović, Siniša Babović, Aleksandar Miljković, Svetlana Pavin, Ana Bolesnikov-Tošić and Sava Barišić
Diagnostics 2024, 14(14), 1493; https://doi.org/10.3390/diagnostics14141493 - 11 Jul 2024
Viewed by 224
Abstract
Rhegmatogenous retinal detachment, a severe eye condition, presents anatomic separation of the neurosensory retina from its outermost layer—the retinal pigment epithelium. Early recognition of this relatively common finding and proper referral of patients to the retinal surgery department is essential in order to [...] Read more.
Rhegmatogenous retinal detachment, a severe eye condition, presents anatomic separation of the neurosensory retina from its outermost layer—the retinal pigment epithelium. Early recognition of this relatively common finding and proper referral of patients to the retinal surgery department is essential in order to minimize its consequent possible severe reduction in vision. Several major surgical methods for the repair of primary rhegmatogenous retinal detachment have been in use over the last several decades, and they all aim to find and close the break in the retina that has caused the detachment. Surgery can be performed as pneumatic retinopexy, pars plana vitrectomy, and/or episcleral surgery (buckling). General surgical trends for reattaching the retina include moving from extraocular to intraocular surgery and from bigger gauge to smaller gauge via minimal invasive vitrectomy surgery (MIVS), with implementing shorter-lasting intraocular tamponades. Surgical options for rhegmatogenous retinal detachment treatment nowadays emphasize gaining retinal reattachment, preferably with one surgery and with minimum damage to the eye. The procedure should not bring secondary eye conditions and complications with severe impairment of visual acuity, and it should be performed on as much as a smaller budget, with possibly peribulbar anesthesia, enabling the patient the quickest possible recovery. It should be adjusted to the patient’s condition, not to the surgeon’s skills or preferences. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Management of Retinal Diseases)
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11 pages, 5118 KiB  
Case Report
Neurofibromatosis Type 1—Retinal Alterations Detectable with Optical Coherence Tomography Angiography
by Anca Elena Târtea, Carmen Luminița Mocanu, Alin Ștefan Ștefănescu Dima, Andreea Cornelia Tănasie, Veronica Maria, Alexandra Oltea Dan and Andrei Theodor Bălășoiu
Diagnostics 2024, 14(13), 1447; https://doi.org/10.3390/diagnostics14131447 - 6 Jul 2024
Viewed by 282
Abstract
Neurofibromatosis type 1 (NF 1) is a multisystemic genetic disorder involving aberrant proliferation of multiple tissues of a neural crest origin. It represents a tumor predisposition syndrome characterized by a wide range of clinical manifestations, such as benign tumors, which primarily affect the [...] Read more.
Neurofibromatosis type 1 (NF 1) is a multisystemic genetic disorder involving aberrant proliferation of multiple tissues of a neural crest origin. It represents a tumor predisposition syndrome characterized by a wide range of clinical manifestations, such as benign tumors, which primarily affect the skin and the nervous system. The most frequent clinical signs of NF 1 include café-au-lait spots all over the surface of the skin and axillary freckling; however, these signs can be accompanied by more severe manifestations such as the growth of both benign and malignant nervous system tumors and skeletal dysplasia, as well as a wide range of ocular manifestations. We report the rare case of retinal microvascular alterations and choroidal nodules in a 15 year old male patient with NF 1, detectable on optical coherence tomography angiography (OCTA). The hyperreflective choroidal nodules modified the profile of the choroidal vasculature. The retinal microvascular alterations in the form of clustered capillaries were detected in the superficial capillary plexus located nasally to the macular region. Retinal vascular abnormalities undetectable on fundus photography or fundoscopy can be present in patients with NF 1. Indirect ophthalmoscopy of our study patient was unremarkable. However, retinal vascular abnormalities were seen on OCTA scans in the superficial capillary plexus and choroidal nodules were detected on raster OCT scans. OCTA represents a useful imaging technique for detecting retinal microvascular abnormalities, which can be considered additional distinctive signs of NF 1. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Management of Retinal Diseases)
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