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Diagnostics
Special Issues
Animal Models in Human Diagnostics
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Animal Models in Human Diagnostics

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3328

Special Issue Editor

Dr. Woon Kyu Lee

E-Mail Website
Guest Editor
Laboratory of Developmental Genetics, Department of Biomedical Sciences, Inha University College of Medicine, Incheon 22212, Republic of Korea
Interests: animal model; mini-pig; efficacy evaluation; disease; preclinical study; inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

There have been remarkable updates during the last decade in animal disease model development. The majority of studies in this field have since the very beginning been carried out using rodent animals. The reason for this is that rodent animals provide easy access, and numerous data can be extrapolated which can be of use to researchers. Recently, however, the limitations of rodent disease modality have led to a push to expand research beyond rodent animals, even though they still represent the strongest candidate for evaluating human disease. This Special Issue invites articles on human disease animal models based on animals of a medium and/or large size, such as dogs or swine. The goal is to showcase the recent focus of research and to provide future directions in terms of animal disease models.

Dr. Woon Kyu Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • efficacy evaluation
  • preclinical study
  • mini-pig

Published Papers (1 paper)

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15 pages, 2629 KiB  
Case Report
Radiologic Evaluation of Portosystemic Shunts in Humans and Small Animals: Review of the Literature with Clinical Case Reports
by Nejc Umek, Domen Plut, Martina Krofič Žel and Aleksandra Domanjko Petrič
Diagnostics 2023, 13(3), 482; https://doi.org/10.3390/diagnostics13030482 - 28 Jan 2023
Cited by 1 | Viewed by 2966
Abstract
The portal venous system is a network of vessels that carry blood from the capillary beds of the major abdominal organs to the liver. During embryology, the portal venous system can develop aberrantly, leading to vascular connections between the portal and systemic venous [...] Read more.
The portal venous system is a network of vessels that carry blood from the capillary beds of the major abdominal organs to the liver. During embryology, the portal venous system can develop aberrantly, leading to vascular connections between the portal and systemic venous circulation known as portosystemic shunts. The purpose of this comparative review with a few short representative case reports was to present the similarities and differences in portosystemic shunts in humans and small animals and their radiologic evaluation. Aberrant vascular connections between the portal and systemic venous circulation enable portal blood to bypass metabolism and detoxification in the liver, leading to significant clinical implications. Portosystemic shunts are very rare in humans, but these connections are much more common in small animals, affecting up to 0.6% of small animals. Portosystemic shunts can be congenital or acquired and are divided into intrahepatic and extrahepatic types. Because of its ability to accurately assess abdominal structures, large vessels, and their flow dynamics without anesthesia, ultrasonography has become the first imaging modality employed for the diagnostic evaluation of portosystemic shunts in both humans and small animals. This is usually followed by contrast-enhanced computed tomographic angiography in order to better define the exact shunt anatomy and to plan treatment. It is important to understand the embryology, anatomy, pathology, and pathophysiology of portosystemic shunts in order to understand the findings of radiologic imaging and to initiate appropriate treatment. Full article
(This article belongs to the Special Issue Animal Models in Human Diagnostics)
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