Early Diagnosis of Mood Disorders: Focus on Bipolar Disorder and Major Depression

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (23 December 2022) | Viewed by 5997

Special Issue Editor


E-Mail Website
Guest Editor
Department of Mental Health and Addiction, Azienda Socio-Sanitaria Territoriale di Monza, 20900 Monza, Italy
Interests: biological markers for mood disorders; treatment-resistant depression; cognition; psychopharmacology

Special Issue Information

Dear Colleagues,

Early diagnosis in psychiatry may represent a challenge for clinicians, although clear diagnostic criteria have been identified in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). This categorical approach allows clinicians to understand each other all over the world, sharing fixed points to differentiate among all subtypes of mental disorders. Nevertheless, misdiagnosis is very frequent in psychiatry, occurring in at least 30–50% of cases (e.g. psychotic bipolar disorder is often initially diagnosed as delusional disorder or major depressive disorder). Notably, an early diagnosis may favour the choice of a proper treatment, helping to improve the long-term outcome of psychiatric patients. Moreover, the categorical approach may be sustained and integrated by a dimensional model that considers clinical features along a continuum between two specific disorders which present some clinical overlap. This approach is gaining increasing interest among researchers and clinicians, appearing particularly adherent to real life, but it needs further and in-depth studies to fully develop.

This Special Issue on “Diagnosis of Psychiatric Disorders” will cover all aspects of the diagnostic process in psychiatry, with particular focus on potential biological markers of mental disorders (especially those easily accessible in clinical practice) and on factors that could contribute to better defining symptoms dimensions and outcome of psychiatric disorders.

Dr. Alice Caldiroli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • misdiagnosis
  • biomarkers
  • dimensional approach
  • outcome

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

21 pages, 2103 KiB  
Article
Psychopathology, Personality and Depression after Acute Coronary Syndrome: A Network Analysis in an Italian Population
by Federica Folesani, Lorenzo Luviè, Cristina Palazzi, Carlo Marchesi, Rodolfo Rossi, Martino Belvederi Murri and Paolo Ossola
Diagnostics 2023, 13(5), 915; https://doi.org/10.3390/diagnostics13050915 - 28 Feb 2023
Cited by 2 | Viewed by 1490
Abstract
Several biopsychosocial factors are associated with the onset of a Major Depressive Episode (MDE) after cardiovascular events. However, little is known of the interaction between trait- and state-like symptoms and characteristics and their role in predisposing cardiac patients to MDEs. Three hundred and [...] Read more.
Several biopsychosocial factors are associated with the onset of a Major Depressive Episode (MDE) after cardiovascular events. However, little is known of the interaction between trait- and state-like symptoms and characteristics and their role in predisposing cardiac patients to MDEs. Three hundred and four subjects were selected among patients admitted for the first time at a Coronary Intensive Care Unit. Assessment comprised personality features, psychiatric symptoms and general psychological distress; the occurrences of MDEs and Major Adverse Cardiovascular Events (MACE) were recorded during a two-year follow-up period. Network analyses of state-like symptoms and trait-like features were compared between patients with and without MDEs and MACE during follow-up. Individuals with and without MDEs differed in sociodemographic characteristics and baseline depressive symptoms. Network comparison revealed significant differences in personality features, not state-like symptoms: the group with MDEs displayed greater Type D personality traits and alexithymia as well as stronger associations between alexithymia and negative affectivity (edge differences between negative affectivity and difficulty identifying feelings was 0.303, and difficulty describing feelings was 0.439). The vulnerability to depression in cardiac patients is associated with personality features but not with state-like symptoms. Personality evaluation at the first cardiac event may help identify individuals more vulnerable to development of an MDE, and they could be referred to specialist care in order to reduce their risk. Full article
Show Figures

Figure 1

18 pages, 353 KiB  
Article
Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?
by Teresa Surace, Enrico Capuzzi, Alice Caldiroli, Alessandro Ceresa, Cecilia Maria Esposito, Anna Maria Auxilia, Ilaria Tagliabue, Martina Capellazzi, Francesca Legnani, Martina Di Paolo, Luisa Cirella, Francesco Zanelli Quarantini, Maria Salvina Signorelli, Eugenio Aguglia, Massimo Clerici and Massimiliano Buoli
Diagnostics 2022, 12(9), 2215; https://doi.org/10.3390/diagnostics12092215 - 13 Sep 2022
Cited by 3 | Viewed by 1675
Abstract
Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample [...] Read more.
Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients. Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD. Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) (p = 0.005), absence of lifetime psychotic symptoms (p = 0.025), presence of poly-substance use disorders (p = 0.033), comorbidity with obesity (p = 0.022), a last mood episode of manic polarity (p = 0.044), and lower bilirubin serum levels (p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance (p = 0.058). Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings. Full article

Review

Jump to: Research

23 pages, 944 KiB  
Review
Current Evidence and Theories in Understanding the Relationship between Cognition and Depression in Childhood and Adolescence: A Narrative Review
by Stefano Barlati, Jacopo Lisoni, Gabriele Nibbio, Giulia Baldacci, Andrea Cicale, Laura Chiara Ferrarin, Mauro Italia, Andrea Zucchetti, Giacomo Deste and Antonio Vita
Diagnostics 2022, 12(10), 2525; https://doi.org/10.3390/diagnostics12102525 - 18 Oct 2022
Cited by 5 | Viewed by 2267
Abstract
The present narrative review has covered the current evidence regarding the role of cognitive impairments during the early phase of major depressive disorder (MDD), attempting to describe the cognitive features in childhood, adolescence and in at-risk individuals. These issues were analyzed considering the [...] Read more.
The present narrative review has covered the current evidence regarding the role of cognitive impairments during the early phase of major depressive disorder (MDD), attempting to describe the cognitive features in childhood, adolescence and in at-risk individuals. These issues were analyzed considering the trait, scar and state hypotheses of MDD by examining the cold and hot dimensions, the latter explained in relation to the current psychological theoretical models of MDD. This search was performed on several electronic databases up to August 2022. Although the present review is the first to have analyzed both cold and hot cognitive impairments considering the trait, scar and state hypotheses, we found that current evidence did not allow to exclusively confirm the validity of one specific hypothesis since several equivocal and discordant results have been proposed in childhood and adolescence samples. Further studies are needed to better characterize possible cognitive dysfunctions assessing more systematically the impairments of cold, hot and social cognition domains and their possible interaction in a developmental perspective. An increased knowledge on these topics will improve the definition of clinical endophenotypes of enhanced risk to progression to MDD and, to hypothesize preventive and therapeutic strategies to reduce negative influences on psychosocial functioning and well-being. Full article
Show Figures

Figure 1

Back to TopTop