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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives in Forensic Diagnosis, 2nd Edition

edited by

Stavroula A. Papadodima

and

Laurent Martrille

submission deadline 31 Oct 2026 | 1 articles | Viewed by 396 | Submission Open

Keywords: autopsy; forensic clinical examination; forensic pathology; postmortem CT/MRI; multidisciplinary approach; post‑mortem biochemical analysis; forensic anthropology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Imaging in Acute Respiratory Distress Syndrome

edited by

Denise Battaglini

submission deadline 31 Oct 2026 | Viewed by 365 | Submission Open

Keywords: acute respiratory distress syndrome (ARDS); computed tomography (CT); lung ultrasound (LUS); electrical impedance tomography (EIT); positron emission tomography (PET); imaging biomarkers; quantitative imaging analysis; multimodal imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Laboratory Testing in Endocrine Diseases

edited by

Tar-Choon Aw

and Chin Shern Lau

submission deadline 31 Oct 2026 | Viewed by 274 | Submission Open

Keywords: endocrine diseases; laboratory testing; clinical correlation; hormone testing; diagnosis and management

(This special issue belongs to the Section Clinical Laboratory Medicine)

Clinical Predictors of Endodontic Treatment Outcomes

edited by

Paulo J. Palma

and

João F. Brochado Martins

submission deadline 31 Oct 2026 | Viewed by 230 | Submission Open

Keywords: diagnosis; endodontics; radiographic imaging; CBCT; outcomes; histology; preoperative diagnosis; apical periodontitis status; clinical predictors treatment planning; improve patient communication; and guide evidence-based decision-making

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

The Use of Portable Devices in Emergency Medicine, Second Edition

edited by

Junko Yamaguchi

submission deadline 31 Oct 2026 | Viewed by 218 | Submission Open

Keywords: portable devices; emergency medicine; smartphone applications; wearable technology; diagnostic accuracy; remote triage; real-time monitoring; emergency medicine education; point-of-care testing; telemedicine

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Biological Rhythms in Laboratory Medicine

edited by

Fernando Marques-Garcia

and

Rubén Fossión

submission deadline 31 Oct 2026 | Viewed by 196 | Submission Open

Keywords: biological rhythms; laboratory medicine; biomarkers; physiology

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diagnosis and Prognosis of Heart Disease, 3rd Edition

edited by

Yuli Huang

submission deadline 31 Oct 2026 | Viewed by 188 | Submission Open

Keywords: heart disease; coronary artery disease; arrhythmia; heart failure; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Functional Parameters in Quantitative CT: Clinical Significance and Diagnostic Applications

edited by Massimo Cressoni and Fatemeh Darvizeh

submission deadline 31 Oct 2026 | Viewed by 183 | Submission Open

Keywords: computed tomography; dual energy; adrenal adenoma; cardiac function; kidney function; perfusion; contrast media; flow velocity; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Innovations and Challenges in Breast Imaging

edited by

Gary J. Whitman

submission deadline 31 Oct 2026 | Viewed by 178 | Submission Open

Keywords: breast imaging; breast ultrasound; mammography; digital breast tomosynthesis; digital mammography; contrast-enhanced mammography; breast MRI; molecular breast imaging; imaging-guided interventional breast procedures; artificial intelligence in imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Molecular Pathology in Maternal–Fetal Medicine: Enabling Precision Diagnosis and Prenatal Management

edited by

Chenming Xu

, Songchang Chen and Yousheng Yan

submission deadline 31 Oct 2026 | Viewed by 164 | Submission Open

Keywords: molecular pathology; prenatal screening; prenatal diagnosis; pregnancy complications; bioinformatics; clinical artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Laboratory Hematology and Flow Cytometry

edited by

John L. Frater

and Cara Lunn Shirai

submission deadline 31 Oct 2026 | Viewed by 157 | Submission Open

Keywords: flow cytometry; spectral flow cytometry; imaging flow cytometry; machine learning in flow cytometry; artificial intelligence in flow cytometry; machine learning in laboratory hematology; artificial intelligence in laboratory hematology; hematology laboratory information systems; automated hematology; complete blood count; hemoglobin analysis

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in the Diagnosis and Management of Vasculitis—2nd Edition

edited by

Alicia Rodríguez-Pla

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: vasculitis; advances; updates; management; treatment; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Technologies in Orthopedic Surgery: Diagnosis and Management, 2nd Edition

edited by Giuseppe Salvatore and Alessandro Mazzola

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: orthopedic surgery; orthopedic diagnosis; orthopedics; computer navigation and augmented reality; robotics; digital templating; 3D printing; artificial intelligence; machine learning; deep learning

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Esophageal Disorders: Modern Approaches

edited by

Wojciech Blonski

and John Jacobs

submission deadline 31 Oct 2026 | Viewed by 144 | Submission Open

Keywords: eosinophilic esophagitis; GERD; achalasia; esophagogastric junction outflow obstruction; lichen planus

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical and Biochemical Diagnosis and Management of Obesity

edited by

Iwona Beń-Skowronek

submission deadline 31 Oct 2026 | Viewed by 143 | Submission Open

Keywords: obesity; biomarker; body composition; metabolic assessment; multidisciplinary management; bariatric surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Next Laboratory Tumor Diagnostics Using Immunologic Methods

edited by

Jong-Han Lee

and Sookwon Ryu

submission deadline 31 Oct 2026 | Viewed by 118 | Submission Open

Keywords: tumor marker; immunotherapy; laboratory medicine; diagnostic immunology; immunologic biosensors

(This special issue belongs to the Section Clinical Laboratory Medicine)

Deep Learning-Based Medical Diagnostics

edited by

Hamid Reza Marateb

submission deadline 31 Oct 2026 | Viewed by 116 | Submission Open

Keywords: deep learning in medical diagnostics; multimodal diagnostic data fusion; AI-assisted medical imaging; biomedical signal analysis; computer-assisted diagnosis; explainable artificial intelligence in healthcare; wearable and point-of-care diagnostics; clinical validation of AI models; intelligent medical decision support

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advanced Imaging for Diagnosis and Management of Musculoskeletal Disorders

edited by

Takeshi Fukuda

submission deadline 31 Oct 2026 | Viewed by 110 | Submission Open

Keywords: musculoskeletal imaging; magnetic resonance imaging (MRI); computed tomography (CT); photon-counting CT; advanced imaging techniques; quantitative imaging; inflammatory arthritis; trauma; sports-related disorders

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Endoscopy and Robotic Surgery

edited by

Long Bai

Hongliang Ren

and

Yanan Wu

submission deadline 31 Oct 2026 | Viewed by 96 | Submission Open

Keywords: endoscopy; medical imaging; medical image analysis; computer-aided diagnosis; clinical validation; cancer detection; inflammatory disease; robotic surgery; endoscopic surgery; surgical data science

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Inflammatory and Infectious Skin Diseases: From Diagnostics to Management

edited by

Giulia Ciccarese

Alessandra Latini

and

Maria Gabriella Donà

submission deadline 31 Oct 2026 | Viewed by 94 | Submission Open

Keywords: skin infections; sexually transmitted infections; human papillomavirus; syphilis; pityriasis rosea; exanthem

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Molecular Residual Disease: From Biomarkers to Precision Medicine

edited by

Eugenio Daviso

and Sarabjot Pabla

submission deadline 31 Oct 2026 | Viewed by 90 | Submission Open

Keywords: molecular residual disease (MRD); liquid biopsy; next-generation sequencing (NGS); ultrasensitive sequencing; multi-modal biomarkers; artificial intelligence; radiomics; circulating tumor DNA (ctDNA); clinical trial endpoint; precision oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Liquid Chromatography–Mass Spectrometry (LC-MS) in the Clinical Laboratory, 2nd Edition

edited by

Siddabasave Gowda B. Gowda

submission deadline 31 Oct 2026 | Viewed by 81 | Submission Open

Keywords: LC-MS; clinical diagnostics; biomarker discovery; metabolomics; lipidomics; clinical samples; method validation; precision medicine; analytical techniques

(This special issue belongs to the Section Clinical Laboratory Medicine)

Recent Advances in Gynecological and Pediatric Imaging

edited by

Gabriele Masselli

submission deadline 31 Oct 2026 | Viewed by 77 | Submission Open

Keywords: gynecological imaging; pediatric imaging; obstetrics imaging; magnetic resonance imaging (MRI); computed tomography (CT); ultrasound; early detection; congenital anomalies

(This special issue belongs to the Section Medical Imaging and Theranostics)

AI-Driven Bioinformatics for Precision and Next-Generation Diagnostics

edited by

Costas Papaloukas

submission deadline 31 Oct 2026 | Viewed by 48 | Submission Open

Keywords: artificial intelligence (AI); machine learning; bioinformatics; next-generation diagnostics; high-throughput omics technologies; digital health platforms; biomarker discovery; digital pathology

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Management of Ear Diseases

edited by

Chin-Kuo Chen

submission deadline 31 Oct 2026 | Viewed by 31 | Submission Open

Keywords: ear diseases; hearing loss; otitis media; cholesteatoma; vestibular disorders; endoscopic ear surgery; diagnostic imaging; artificial intelligence; digital health; clinical outcomes

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis, Management, and Prognosis of Liver Diseases

edited by

Chien Hao Huang

submission deadline 31 Oct 2026 | Viewed by 21 | Submission Open

Keywords: acute liver disease; chronic liver disease; viral hepatitis; liver cirrhosis; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); hepatocellular carcinoma; biomarkers; artificial intelligence; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Clinical Diagnosis and Prognosis of Urologic Oncology

edited by

Sung Han Kim

submission deadline 31 Oct 2026 | Viewed by 20 | Submission Open

Keywords: biomarkers; molecular diagnostics; precision medicine; urologic oncology; clinical prognosis; disease stratification

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Precision Screening and Risk-Based Management in Women’s Health

edited by

Chia-Yen Huang

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: precision screening; risk-based management; women’ s health; gynecologic cancer; cervical cancer screening; HPV testing; cervical neoplasia; endometrial cancer; ovarian cancer; biomarkers; molecular diagnostics; risk stratification; cytology; epidemiology; precision prevention

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in Cardiovascular Imaging

edited by

Gudrun Feuchtner

submission deadline 31 Oct 2026 | Viewed by 5 | Submission Open

Keywords: coronary CTA; coronary artery disease; computed tomography angiography; spectral imaging; photon-counting CT; atherosclerosis; structural heart disease; valves and devices; atrial fibrillation; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnostic Advances in Obstetrics and Gynecology, Breast Disease and Women’s Health

edited by Menelaos Zafrakas

submission deadline 30 Nov 2026 | 4 articles | Viewed by 12385 | Submission Open

Keywords: obstetrics; gynecology; maternal– fetal medicine; breast; women’ s health; diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Application of Artificial Intelligence to Advance Individualized Diagnosis and Treatment in Emergency and Critical Care Medicine, 2nd Edition

edited by

Zhongheng Zhang

submission deadline 30 Nov 2026 | 5 articles | Viewed by 9090 | Submission Open

Keywords: critical care; sepsis; artificial intelligence; predictive analytics; clustering; acute kidney injury; emergency medicine; transcriptome

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis, Treatment, and Prognosis of Breast Cancer

edited by

Marko Buta

submission deadline 30 Nov 2026 | 6 articles | Viewed by 7060 | Submission Open

Keywords: breast cancer diagnosis; molecular profiling; artificial intelligence; targeted therapy; immunotherapy; treatment strategies; prognostic markers; triple-negative breast cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostics of Chronic Kidney Disease

edited by

Tomasz Gołębiowski

and

Andrzej Konieczny

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6926 | Submission Open

Keywords: chronic kidney disease; diabetic nephropathy; glomerulonephritis; acid– base disorders; uremic toxin; artificial intelligence; metabolic bone disease; vascular access; arteriovenous fistula; catheter; hemodialysis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Alzheimer's Disease Diagnosis Based on Deep Learning

edited by Anees Abrol

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5939 | Submission Open

Keywords: Alzheimer's disease (AD); deep learning; MRI; demographic information; disease probability map; convolutional neural network (CNN)

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Opportunities in Laboratory Medicine in the Era of Genetic Testing

edited by

Fernanda De-Paris

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4392 | Submission Open

Keywords: laboratory medicine; genetic testing; molecular diagnostics; personalized medicine; clinical decision-making; infectious disease diagnosis; precision oncology

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diagnosis and Management of Vascular Diseases

edited by Tiffany R. Bellomo and Abhisekh A. Mohapatra

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4256 | Submission Open

Keywords: diagnosis; management; vascular diseases; marker; non-invasive imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Magnetic Resonance Imaging

edited by

Aydin Eresen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2210 | Submission Open

Keywords: magnetic resonance imaging; artificial intelligence; diagnostic medicine; MRI data analysis; image processing

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Transforming Cancer Care Through Molecular Diagnostics and Biomarker Discovery

edited by

Babak Behnam

submission deadline 30 Nov 2026 | Viewed by 1964 | Submission Open

Keywords: molecular diagnostics; cancer biomarkers; precision oncology; liquid biopsy; genomic profiling; clinical translation; early detection; therapeutic monitoring; multi-omic analysis; next-generation sequencing

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Innovations in Kidney Disease Diagnostics: Organoids, Pathology, and Clinical Insights

edited by

Kenji Tsuji

submission deadline 30 Nov 2026 | Viewed by 1801 | Submission Open

Keywords: chronic kidney disease; diabetic kidney disease; glomerulonephritis; polycystic kidney diseases; renal pathology; biomarker; kidney regeneration; hemodialysis; peritoneal dialysis; diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Application of Ultrasound Technology in the Diagnosis of Skin Diseases

edited by

Priscila Giavedoni

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1691 | Submission Open

Keywords: skin ultrasound; cutaneous imaging; inflammatory skin diseases; skin tumors; high-frequency ultrasound; diagnostic imaging; medical imaging; ultrasound-guided procedures; dermatology; skin assessment

(This special issue belongs to the Section Medical Imaging and Theranostics)

AI for Medical Diagnosis: From Algorithms to Clinical Integration

edited by

Hyun-Soo Choi

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1373 | Submission Open

Keywords: novel neural architectures; explainable and trustworthy AI (XAI); medical foundation models; algorithmic robustness and generalization; multimodal data integration; data-efficient learning (few-shot/self-supervised); clinical decision support systems (CDSSs); real-time diagnostic algorithms; edge AI for medical devices

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Global Advances in EGD and Colonoscopy: The Convergence of Advanced Imaging and AI

edited by

Naohisa Yoshida

submission deadline 30 Nov 2026 | Viewed by 1242 | Submission Open

Keywords: esophagogastroduodenoscopy (EGD); colonoscopy; artificial intelligence; image-enhanced endoscopy; optical biopsy

(This special issue belongs to the Section Biomedical Optics)

Diagnostics and Management of Sarcopenia, Frailty, and Aging

edited by Jong Geol Do

submission deadline 30 Nov 2026 | Viewed by 1005 | Submission Open

Keywords: sarcopenia; frailty; aging; geriatric; rehabilitation; biomarkers; digital health

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Next-Generation Imaging and AI in Structural Heart Disease: From Detection to Risk Stratification and Prognosis

edited by

Mao Chen

submission deadline 30 Nov 2026 | Viewed by 996 | Submission Open

Keywords: structural heart disease; artificial intelligence; diagnostic test; risk stratification; image innovation; deep learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Artificial Intelligence in Biomedical Image Analysis 2026

edited by

Jasjit S. Suri

submission deadline 30 Nov 2026 | 1 articles | Viewed by 946 | Submission Open

Keywords: artificial intelligence; biomedical image analysis; diagnosis; cancer; neurological disorders

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Innovative Research and Operational Advances in the Diagnosis of Hematologic Diseases

edited by

Robert S. Ohgami

submission deadline 30 Nov 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: hematologic diseases; genomic diagnostics; digital pathology; biomarker; laboratory diagnostics

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Lung Diseases

edited by

Fu-Zong Wu

and

Nevenka Piskac Zivkovic

submission deadline 30 Nov 2026 | 1 articles | Viewed by 818 | Submission Open

Keywords: endobronchial ultrasound; navigational bronchoscopy; robotic bronchoscopy; cryobiopsy; lung cancer; interstitial lung diseases; OMICS approaches; proteomics; emphysema; chronic obstructive pulmonary disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Thrombosis Diagnosis and Antithrombotic Therapy

edited by Ovidio De Filippo,

Fabrizio D’Ascenzo

and Francesco Antonio Veneziano

submission deadline 30 Nov 2026 | 1 articles | Viewed by 691 | Submission Open

Keywords: antithrombotic therapy; ischemic heart disease; risk stratification; personalized medicine; dual antiplatelet therapy; bleeding risk; coronary artery disease; artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Interdisciplinary Approaches to Musculoskeletal Disorders: From Imaging to Management

edited by

Ralf Henkelmann

and Jeanette Henkelmann

submission deadline 30 Nov 2026 | 1 articles | Viewed by 484 | Submission Open

Keywords: musculoskeletal imaging; interdisciplinary management; clinical decision-making; quantitative imaging; imaging biomarkers; alignment and positioning; artificial intelligence; surgical planning

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Molecular Pathology and Biomarkers for Tumor Diagnosis and Prognosis

edited by