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Therapies and Prognosis of Oral Cancer

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Oral Health".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 3421

Special Issue Editor


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Guest Editor
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan
Interests: oral cancer; oral andmaxillofacial surgery

Special Issue Information

Dear Colleagues,

Oral cancer is one of the rare cancers in many developed countries, although it occurs very frequently in some Asian regions that prefer betel nut. So far, various clinical studies on oral cancers have been included in "head and neck cancer", and various treatment guidelines have been published. However, although the sites of pharyngeal cancer and oral cancer are close to each other, their carcinogenic mechanisms and responses to radiation and anticancer drugs are significantly different. Since oral cancer is a rare cancer, it is difficult to conduct clinical studies targeting only oral cancer, and, therefore, there are many studies on oral cancers with a small number of cases with a low level of evidence.

The incidence of oral cancer is increasing in many countries. Treatment of oral cancer has various problems, such as ensuring aesthetics and maintaining oral function, as well as life prognosis. The purpose of this Special Issue is to collect the results of basic and clinical research on oral cancer, especially clinical research conducted by multiple institutions, from all over the world, and to obtain findings that will lead to improved prognosis and quality of life for patients with oral cancer. 

Prof. Dr. Masahiro Umeda
Guest Editor

Manuscript Submission Information

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Keywords

  • oral cancer
  • surgery
  • adiotherapy
  • chemotherapy
  • multicenter study
  • clinical study
  • prognosis
  • mechanisms
  • oral function
  • malignant tumor
  • oral health
  • oral and maxillofacial surgery
  • neck dissection
  • prophylaxis

Published Papers (2 papers)

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Research

10 pages, 851 KiB  
Article
Evaluation of Oral Mucosal Lesions Using the IllumiScan® Fluorescence Visualisation Device: Distinguishing Squamous Cell Carcinoma
by Yuki Taguchi, Shigeaki Toratani, Kensaku Matsui, Seiya Hayashi, Natsuki Eboshida, Atsuko Hamada, Nanako Ito, Fumitaka Obayashi, Naohiro Kimura and Souichi Yanamoto
Int. J. Environ. Res. Public Health 2022, 19(16), 10414; https://doi.org/10.3390/ijerph191610414 - 21 Aug 2022
Cited by 1 | Viewed by 1362
Abstract
We evaluated whether fluorescence intensity (FI) and its coefficient of variation (CV) can be used to diagnose squamous cell carcinoma (SCC) through IllumiScan®, an oral mucosa fluorescence visualisation (FV) device. Overall, 190 patients with oral mucosal lesions (OMLs; SCC, 59; non-SCC [...] Read more.
We evaluated whether fluorescence intensity (FI) and its coefficient of variation (CV) can be used to diagnose squamous cell carcinoma (SCC) through IllumiScan®, an oral mucosa fluorescence visualisation (FV) device. Overall, 190 patients with oral mucosal lesions (OMLs; SCC, 59; non-SCC OMLs, 131) and 49 patients with normal oral mucosa (NOM) were enrolled between January 2019 and March 2021. The FI of the images was analysed using image analysis software. After establishing regions of interest for SCC, non-SCC, and NOM, the average FI, standard deviation (SD), and CV were compared. There was a significant difference in the average FI for all pairs of comparisons. The SD was not significantly different between the SCC and NOM groups (p = 0.07). The CV differed significantly for NOM (p < 0.001) and non-SCC groups (p < 0.001) relative to the SCC group but was not different between NOM and non-SCC groups (p = 0.15). Univariate analysis of SCC and non-SCC groups showed significant differences for all factors, except age. However, multivariate analysis showed a significant intergroup difference only in the CV (p = 0.038). Therefore, analysing the CV in FV images of OML may be useful for the diagnosis of oral cancer. Full article
(This article belongs to the Special Issue Therapies and Prognosis of Oral Cancer)
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12 pages, 1205 KiB  
Article
Treatment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis
by Yuki Sakamoto, Mitsunobu Otsuru, Takumi Hasegawa, Masaya Akashi, Shin-ichi Yamada, Hiroshi Kurita, Masaya Okura, Nobuhiro Yamakawa, Tadaaki Kirita, Souichi Yanamoto, Masahiro Umeda and Yuka Kojima
Int. J. Environ. Res. Public Health 2022, 19(15), 9229; https://doi.org/10.3390/ijerph19159229 - 28 Jul 2022
Cited by 2 | Viewed by 1632
Abstract
The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients [...] Read more.
The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS (p = 0.011) and DSS (p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions. Full article
(This article belongs to the Special Issue Therapies and Prognosis of Oral Cancer)
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