Exercise Metabolism and Health

Dear Colleagues,

A sedentary lifestyle combined with an inappropriate energy intake contributes to the development of non-communicable diseases. Many of the risk factors for those chronic diseases are modifiable, from early childhood or even before.

Adipose tissue and skeletal muscle secrete molecules capable of modulating local and systemic metabolism. Liver is also related with energy storing and utilization and it has been recently shown that produces and secretes hepatokines that may convey whole-body beneficial effects. Finally, heart and bone can also produce and secrete hormones that regulate several metabolic processes.

Regular physical activity not only produces metabolic, physiological, and molecular adaptations to skeletal muscle but also to adipose tissue, liver, heart, and bone. Exercise is known to be one of the best non-pharmacological interventions for the prevention and treatment of many diseases. However, there is an extensive lack of knowledge on endocrine or epigenetic adaptations to exercise and the crosstalk between the abovementioned tissues produced by regular physical activity or exercise.

The aims of the proposed research topic are (but not limited to):

1. The relationship between the newly described endocrine organs (skeletal muscle, adipose tissue, liver, heart and bone).
2. Identification and characterization of new hormones, miRNAs or exosomes by skeletal muscle, adipose tissue, liver, heart and bone.
3. The constitutively or regulatory secreted hormones by the abovementioned organs under physical exercise conditions.
4. The effect of exercise-induced fatigue on metabolic, physiological, and molecular adaptations.
5. The effect of different types of exercise training interventions (e.g., resistance training, moderate intensity continuous training, high-intensity interval training) on metabolic, physiological, and molecular adaptations.
6. Exercise-related metabolic, physiological, and molecular adaptations of skeletal muscle, adipose tissue, liver, heart, and bone in individuals with metabolic diseases.
7. Exercise prescription to achieve optimal metabolic, physiological, and molecular adaptations in the crosstalk among skeletal muscle, adipose tissue, liver, heart, or bone.
8. The effect of exercise or metabolic diseases in the tissue crosstalk and coupling among different organs in children, adults, elderly, athletes, or pregnant woman.
9. The effect of exercise or metabolic diseases during preconception or pregnancy in the offspring tissue crosstalk.

Dr. Anna Prats-Puig
Dr. Sergi Garcia-Retortillo
Guest Editors

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