Solid-Phase Peptides: Syntheses and Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1711
Special Issue Editor
Interests: organic synthesis; solid phase peptide synthesis; pseudopeptides as self-assembled foldamers; targeted peptides as therapeutic drug delivery systems for biological applications; anticancer photodynamic therapy applications; nuclear medicine applications; neurodegenerative applications; cerebrovascular applications
Special Issue Information
Dear Colleagues,
This Special Issue of International Journal of Molecular Sciences is dedicated to “Solid-Phase Peptides: Syntheses and Applications”. Peptides are small proteins made up of amino acid sequences (i.e., up to 50–100 amino acids) attached to each other with peptide bonds. Natural peptides play a pivotal role in all living organisms owing to their participation in nearly all physiological processes. One century since the discovery of the insulin peptide for diabetes treatment, the interest generated by the natural and synthetic peptides as therapeutic drugs for various disease treatments (e.g., cancer, cardiovascular, neurogenerative, etc.) has steadily increased.
Broadly speaking, in peptide synthesis, the repeated purification steps after each amino acid coupling cycle are the most laborious, expensive, and time-consuming steps, which significantly increases the overall synthesis time. Solid-Phase Peptide Synthesis (SPPS) is a powerful technique simplifying and facilitating the synthesis of peptides. SPPS is based on a stepwise construction of peptides from their C-terminus anchored to an insoluble polymer (i.e., resin) through iterative coupling reactions of protected amino acids. The use of resins can dramatically reduce the synthesis time along with an increase in crude purity and yield by replacing the purification steps with simple washing steps of the resin.
Since it was pioneered by Bruce Merrifield in 1963, SPPS has now become a routine technique with continuous modernizations (e.g., Fmoc/tBu approach, automation, microwave assistance, etc.) and largely used by researchers in the development of new therapeutic drugs for various diseases.
This Special Issue will provide an opportunity to publish research results or review articles dedicated to all aspects of Solid-Phase Peptides, focusing on them at a molecular level, and including, but not limited to, peptide–protein interactions, synthesis methodology (e.g., new resins, new coupling reagents, etc.), the isolation of new bioactive peptides from nature, the development of new bioactive synthetic peptides, all peptide-based approaches for disease treatments and/or drug delivery, etc.
Dr. Samir Acherar
Guest Editor
Manuscript Submission Information
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Keywords
- peptide
- peptide-based compounds
- solid-phase synthesis
- molecular interactions
- methodology
- disease treatments
- drug delivery
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