Stem Cell Regenerative Medicine: From Molecular Basis to Translational Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 3414
Special Issue Editor
Special Issue Information
Dear Colleagues,
Stem cells are a rare subpopulation defined by the potential to self-renew and differentiate into specific cell types. The functional distinction between stem and progenitor cells is well-established in several tissues, particularly in the blood. There, hematopoietic stem cells preserve their self-renewal potential and reconstitution ability in the bone marrow niche. Bone marrow represents a unique setting in which to examine how stroma influences tissue function. Multiple bone marrow stromal cell types serve as regulators of hematopoiesis, and the dysfunction of some causes myelodysplasia and leukemia.
A population of stem-like cells has been reported to possess the ability to self-renewal, invasion, metastasis, and engraftment of distant tissues. This unique cell subpopulation has been designated as cancer stem cells. Cancer stem cells were first identified in leukemia and the contributions of cancer stem cells to cancer progression have been reported in many different types of cancers. The cancer stem cell hypothesis attempts to explain tumor cell heterogeneity based on the existence of stem cell-like cells within solid tumors.
We encourage the submission of original full research papers as well as review articles dealing with novel mechanistic insights and details of the molecular signatures of stem cell biology. We also encourage the submission of manuscripts that focus on translating basic molecular knowledge to new medical applications in stem cell biology. Articles reporting novel technologies aimed at identifying disease biomarkers are also welcomed.
Topics include, but are not limited to, the following:
- New insights into the molecular mechanisms of stem cell biology;
- Stem cell emerging technologies (e.g., bioinformatics, proteomics, metabolomics, tissue arrays, imaging);
- New molecular biomarkers and profiling of cancer stem cells: diagnosis, prognosis, stratification and efficacy;
- Molecular interactions in the niche, including stem cells, immune cells, and stroma cells;
- Genomic profiling of stem cells, including genetics, epigenetics, and genomic instability;
- Preclinical research leads to novel therapies derived from molecular processes and cellular interactions, including gene therapy, nanomedicine-based therapies, and stem cell-based therapy.
Dr. Dongjun Lee
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- adult stem cells
- embryonic stem cells
- induced pluripotent stem cells
- hematopoietic stem cells
- hematological malignancy
- regenerative medicine
- cancer stem cells
- niche
- stem cell therapy
- gene editing
- CRISPR/Cas9
- organoids
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
