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Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1450

Special Issue Editor

Dr. Ioannis Kanakis

E-Mail Website
Guest Editor
Chester Medical School, University of Chester, Bache Hall, Countess View, Chester CH2 1BR, UK
Interests: clinical biochemistry; bone metastases; musculoskeletal ageing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetic Bone Disease (DBD) is an emerging complication in Diabetes Mellitus (DM), characterized by alterations in bone metabolism and increased fracture risk. The pathophysiology of DBD involves a complex interplay between hyperglycaemia, insulin deficiency or resistance, and advanced glycation end-products (AGEs) that impair bone quality and remodelling. Therapeutic management of DBD requires a multifaceted approach, which is often challenging, including stringent glycaemic control, lifestyle modifications, and pharmacological interventions. Multidisciplinary care involving endocrinologists, orthopaedic specialists, and dietitians is essential for optimal management. As research advances, a deeper understanding of DBD’s molecular mechanisms will likely yield new therapeutic targets, improving patient outcomes and quality of life.

This Special Issue aims to focus on new insights, novel developments and discoveries, current challenges, and future perspectives in the field of Diabetic Bone Disease to and provide a comprehensive update.

We invite basic, clinical, and translational researchers in relevant fields to submit original research articles, literature reviews, systematic reviews, and hypothesis-driven papers addressing important issues such as, but not limited to, the following:

  • New advances in understanding the pathophysiological mechanisms that drive DBD.
  • How antidiabetic interventions affect bone metabolism via studying alterations in bone biochemical markers, BMD, fracture risk, etc.
  • Utilisation of in vitro models to elucidate bone cell behaviour and molecular changes in a hyperglycaemic environment.
  • Identification of bone microarchitecture alterations in Diabetes.

Dr. Ioannis Kanakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic bone disease
  • molecular mechanisms
  • therapeutic approaches

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Published Papers (1 paper)

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Review

17 pages, 4354 KiB  
Review
Impact of Different Anti-Hyperglycaemic Treatments on Bone Turnover Markers and Bone Mineral Density in Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis
by Md Sadman Sakib Saadi, Rajib Das, Adhithya Mullath Ullas, Diane E. Powell, Emma Wilson, Ioanna Myrtziou, Chadi Rakieh and Ioannis Kanakis
Int. J. Mol. Sci. 2024, 25(14), 7988; https://doi.org/10.3390/ijms25147988 - 22 Jul 2024
Viewed by 1277
Abstract
Diabetic bone disease (DBD) is a frequent complication in patients with type 2 diabetes mellitus (T2DM), characterised by altered bone mineral density (BMD) and bone turnover marker (BTMs) levels. The impact of different anti-diabetic medications on the skeleton remains unclear, and studies have [...] Read more.
Diabetic bone disease (DBD) is a frequent complication in patients with type 2 diabetes mellitus (T2DM), characterised by altered bone mineral density (BMD) and bone turnover marker (BTMs) levels. The impact of different anti-diabetic medications on the skeleton remains unclear, and studies have reported conflicting results; thus, the need for a comprehensive systematic review is of paramount importance. A systematic search was conducted in PubMed and the Cochrane Library. The primary outcomes assessed were changes in BMD in relation to different anatomical sites and BTMs, including mainly P1NP and CTX as well as OPG, OCN, B-ALP and RANK-L. Risk of bias was evaluated using the JADAD score. The meta-analysis of 19 randomised controlled trials comprising 4914 patients showed that anti-diabetic medications overall increased BMD at the lumbar spine (SMD: 0.93, 95% CI [0.13, 1.73], p = 0.02), femoral neck (SMD: 1.10, 95% CI [0.47, 1.74], p = 0.0007) and in total hip (SMD: 0.33, 95% CI [−0.25, 0.92], p = 0.27) in comparison with placebo, but when compared with metformin, the overall effect favoured metformin over other treatments (SMD: −0.23, 95% CI [−0.39, −0.07], p = 0.004). GLP-1 receptor agonists and insulin analogues seem to improve BMD compared to placebo, while SGLT2 inhibitors and thiazolidinediones (TZDs) showed no significant effect, although studies’ number cannot lead to safe conclusions. For BTMs, TZDs significantly increased P1NP levels compared to placebo. However, no significant differences were observed for CTX, B-ALP, OCN, OPG, and RANK-L between anti-diabetic drugs and metformin or placebo. High heterogeneity and diverse follow-up durations among studies were evident, which obscures the validity of the results. This review highlights the variable effects of anti-diabetic drugs on DBD in T2DM patients, emphasising the need for long-term trials with robust designs to better understand these relationships and inform clinical decisions. Full article
(This article belongs to the Special Issue Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches)
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