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Current Advances in Gut Microbiota in Human Diseases and Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1300

Special Issue Editor


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Guest Editor
Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Black Mountain Science and Innovation Park, Canberra, ACT 2601, Australia
Interests: metabolomics; proteomics; analytical biochemistry; future proteins; food and nutrition; fermentation; biomass waste recycling
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Special Issue Information

Dear Colleagues,

Multidrug resistance (MDR), also known as antimicrobial resistance (AMR), is becoming a critical global security issue due to widespread antibiotic misuse and limited development of new drugs. Recent studies highlight a concerning rise in deaths linked to bacterial AMR, emphasizing the urgency of the situation.

While novel drugs are crucial in combating MDR, the role of nutrition in bolstering resilience against pathogens, especially through a healthy gut microbiome, is often overlooked in clinical settings. Understanding how nutrition impacts the gut microbiome's response to AMR is vital for combatting infections effectively.

Exploring the age-old concept of "Food is Medicine" through modern scientific tools can offer insights into the health implications of nutrition practices. Addressing the gaps in knowledge about how different nutritional factors influence the gut microbiome's response to AMR pathogens is essential, especially in the food and nutrition industry.

We invite research focusing on molecular mechanisms addressing AMR/MDR infections and the role of nutrition in fostering a resilient gut microbiome. Contributions bridging microbiological and biochemical insights in human health, agriculture, and nutrition sectors, including veterinary perspectives, are encouraged.

Dr. Avinash Karpe
Guest Editor

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Keywords

  • antimicrobial and multidrug resistance (AMR, MDR)
  • gut microbiome
  • systems biology
  • novel technologies
  • principles and mechanism of action
  • food and nutrition
  • food as Medicine

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Published Papers (1 paper)

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Research

19 pages, 4650 KiB  
Article
Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and Its Impact on Blood Pressure Status: A Cross-Sectional Study
by Chung-Guei Huang, Wan-Ni Lin, Li-Jen Hsin, Tuan-Jen Fang, Hsueh-Yu Li, Chin-Chia Lee and Li-Ang Lee
Int. J. Mol. Sci. 2024, 25(24), 13344; https://doi.org/10.3390/ijms252413344 - 12 Dec 2024
Viewed by 694
Abstract
Obstructive sleep apnea syndrome (OSAS) is prevalent among children and is associated with elevated blood pressure (BP), posing a risk for future hypertension and cardiovascular diseases. While the roles of gut microbiota and systemic inflammation in OSAS pathogenesis are recognized in adults and [...] Read more.
Obstructive sleep apnea syndrome (OSAS) is prevalent among children and is associated with elevated blood pressure (BP), posing a risk for future hypertension and cardiovascular diseases. While the roles of gut microbiota and systemic inflammation in OSAS pathogenesis are recognized in adults and animal models, their impact on pediatric BP remains less understood. This cross-sectional study explored the relationships between polysomnographic parameters, gut microbiota, systemic inflammation, and BP in 60 children with OSAS. Significant associations between specific microbial profiles—including beta diversity and 31 marker microbes—and BP variations were observed. These microbial profiles correlated with significant alterations in systemic inflammation markers like interleukin-17 and tumor necrosis factor-α. Notably, the relative abundance of Acinetobacter was related to fluctuations in these inflammatory markers and BP levels. The research further highlighted the unique microbial and cytokine profiles exhibited by children with different BP levels, indicating a substantial role of gut microbiota and systemic inflammation in influencing pediatric cardiovascular health. The findings suggest integrating gut microbiota management into comprehensive cardiovascular risk strategies for children with OSAS. This initiative underscores the need for further investigations to decode the mechanisms behind these associations, which could lead to innovative treatments for pediatric OSAS. Full article
(This article belongs to the Special Issue Current Advances in Gut Microbiota in Human Diseases and Health)
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