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Exosomes—3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1862

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Guest Editor
Robert C. Byrd Biotechnology Science Center, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
Interests: genetic markers; sleep apnea; exosomes; single cell; snRNA-seq; metabolic dysfunction; animal models for sleep apnea
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Special Issue Information

Dear Colleagues,

Intercellular Communication between neighbored and distant cells are crucial for cell survival and responding to endocrine signaling. Exosomes, a class of extracellular vesicle (EVs) involved in cell to cell communication, are released by most of all biological fluids and emerging as novel cell-cell communication mediators in physiological and pathological conditions. These exosomes differ from other EVs based on their biogenesis, release pathways, size content, and function. Furthermore, these exosomes have shown to carry cell-specific cargos such as lipids, proteins, and miRNAs, mRNAs, and other genetic materials, and can be selectively taken up by neighboring or distant cells far from their release, which may ultimately reprogram the recipient cells distal from their release. Thus, exosomes and their biologically active cargos may offer potential biomarkers of diagnosis and therapeutic targets in a range of diseases, such as chronic inflammation, obesity, cardiovascular, neurodegenerative diseases, metabolic diseases, and tumors. This special issue aims to present new knowledge and covers all the topics relevant to exosomes in human cancers, cardiovascular, obesity, sleep, and neurogenerative deficit. We invite researchers to contribute either with original research or review articles focusing on every aspect regarding the role and function of exosomes in healthy and pathological conditions including the onset and progression of cancer, sleep, and heart diseases.

Due to the success of the 1st and 2nd editions, we would like to add more results and new insights from recent research projects.

https://www.mdpi.com/journal/ijms/special_issues/exosome

https://www.mdpi.com/journal/ijms/special_issues/VD106X1HQK

You can read more my publications at the following link: https://pubmed.ncbi.nlm.nih.gov/?term=khalyfa+a%2C+exosomes&sort=date&show_snippets=off

Dr. Abdelnaby Khalyfa
Guest Editor

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Keywords

  • extracellular vesicles (EVs)
  • exosomes
  • cancer
  • sleep cardiovascular diseases
  • lung disease and upper airways
  • obesity
  • sleep and end-organ morbidity

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Published Papers (1 paper)

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Research

8 pages, 8360 KiB  
Communication
Exosome Therapy: A Novel Approach for Enhancing Estrogen Levels in Perimenopause
by Samar Alkhrait, Mervat M. Omran, Mohammad Mousaei Ghasroldasht, Hang-Soo Park, Riham Katkhuda and Ayman Al-Hendy
Int. J. Mol. Sci. 2024, 25(13), 7075; https://doi.org/10.3390/ijms25137075 - 27 Jun 2024
Viewed by 1180
Abstract
Perimenopause significantly impacts women’s health globally, often managed with hormone replacement therapy (HRT) despite the associated risks. This study explores a novel alternative exosome therapy, aimed at stimulating estrogen production in ovarian tissues, thus offering a potential non-hormonal treatment for perimenopausal symptoms. Employing [...] Read more.
Perimenopause significantly impacts women’s health globally, often managed with hormone replacement therapy (HRT) despite the associated risks. This study explores a novel alternative exosome therapy, aimed at stimulating estrogen production in ovarian tissues, thus offering a potential non-hormonal treatment for perimenopausal symptoms. Employing ex vivo methodologies, ovarian cortex specimens from perimenopausal women were treated with exosomes derived from human umbilical cord mesenchymal stem cells and cultured under specific conditions (patent number: PCT/US2022/073467). The exosomes were produced under cyclic guanosine monophosphate (cGMP) conditions, ensuring high safety standards. Estrogen levels were quantified using enzyme-linked immunosorbent assay (ELISA), and gene expression changes in estrogen and follicle-stimulating hormone (FSH) receptors were assessed via quantitative polymerase chain reaction (PCR). Immunohistochemistry (IHC) was utilized to evaluate cellular proliferation and apoptotic markers. The results indicated a significant increase in estrogen levels and estrogen receptor-alpha (Erα) expression in treated tissues compared to controls. Additionally, a decrease in apoptotic markers and an increase in cellular proliferation markers were observed. These findings suggest that exosome therapy can effectively enhance estrogen production and modulate receptor sensitivity in perimenopausal ovarian tissues. This approach could serve as a safer alternative to HRT, aligning with the body’s natural regulatory mechanisms and potentially offering a more effective treatment option for managing perimenopausal symptoms. Full article
(This article belongs to the Special Issue Exosomes—3rd Edition)
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