Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2024 | Viewed by 152
Special Issue Editors
Interests: human physiology; cell physiology; membrane transport systems; bioactive compound; oxidative stress; human health
Special Issues, Collections and Topics in MDPI journals
Interests: physiology; ion trasport; band 3 protein; erythrocytes; oxidative stress; aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress (OS) is frequently described as the balance between the production of reactive species (RS), including oxygen and nitrogen, in biological systems and the ability of the latter to defend themselves through sophisticated antioxidant machinery. At physiological levels, some oxidants, in controlled amounts, possess important signaling functions within the cell. Specifically, cells can generate RS with the function of second messengers, using them for intracellular signaling and stimulating redox-sensitive signaling pathways to modify the cellular content of cytoprotective regulatory proteins. In fact, the redox state in the cell is normally regulated by a complex endogenous antioxidant system composed of proteins with enzymatic activity and non-enzymatic proteins able to quickly neutralize or ensure a low production of RS. Nevertheless, when oxidants are produced in excess or when the antioxidant defenses that regulate them are ineffective, this balance can be perturbed, thus resulting in the development of an oxidative condition. Oxidative products are highly reactive and can directly or indirectly modulate the functions of many enzymes and transcription factors through complex signaling cascades. In particular, some of the pathways are preferentially linked to enhanced survival, while others are more frequently associated with cell death and constitute important avenues for therapeutic interventions aimed at limiting oxidative damage or, alternatively, attenuating its consequences. Furthermore, the magnitude and exposure of the insult, as well as the cell type involved, are key elements in defining which pathways are activated as well as the final cell outcome.
The aim of this Special Issue is to collect and contribute to the dissemination of high-quality research articles as well as review articles focusing on the relationship between oxidative stress-related diseases and cellular responses in different pathologies, including ischemic stroke, diabetes, kidney disease, cardiovascular, and neurodegenerative diseases. In addition, molecular targets of cellular membranes, as well as their potential modulation under oxidative stress, will also be considered in an attempt to provide more information about cell responses to oxidative stress and its possible modulation by novel pharmacological strategies.
Dr. Alessia Remigante
Dr. Rossana Morabito
Guest Editors
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Keywords
- molecular targets of oxidative stress in oxidative stress related-diseases
- oxidative stress and oxidative stress-related pathologies
- cellular response to oxidative stress
- oxidative stress and apoptosis in oxidative stress-related diseases
- oxidative stress and related cell signaling
- cell adaptation to oxidative stress
- biomarkers of oxidative stress in disease
- beneficial effects of natural or synthetic antioxidants in oxidative stress-related diseases
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