Tumor Viruses: Infection, Carcinogenesis, and Treatment

Dear Colleagues,

Tumor viruses represent a significant class of pathogens that contribute to human malignancies by establishing persistent infections, modulating host immune responses, and disrupting normal cellular processes through genetic and epigenetic mechanisms. Several viruses—including Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B and C viruses (HBV and HCV), human T-cell leukemia virus type 1 (HTLV-1), Kaposi’s sarcoma-associated herpesvirus (KSHV), and Merkel cell polyomavirus (MCPyV)—are well-established human oncogenic viruses. In addition, a growing number of viruses are being investigated for their potential roles in tumor initiation and progression, warranting broader exploration.

This Special Issue will delve into the multifaceted roles of tumor viruses in carcinogenesis, with a focus on key processes such as viral latency, immune evasion, oncogene expression, and the hijacking of host signaling pathways. We will also highlight state-of-the-art developments in the diagnosis, prevention, and treatment of virus-associated cancers. This includes progress in antiviral drug development, therapeutic and prophylactic vaccines, immune-based therapies, and innovative gene-editing technologies such as CRISPR/Cas systems.

We invite the submission of original research articles, comprehensive reviews, communications, and perspective papers that advance our understanding of tumor viruses and their role in oncogenesis. Submissions that support translational research, clinical innovation, or public health impact are particularly encouraged. This Special Issue aims to foster a multidisciplinary dialogue in oncogenic virology and promote the development of novel strategies for the management of virus-associated malignancies.

Dr. Sherif T.S. Hassan
Guest Editor

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