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Molecular Diagnostics and Genomics of Tumors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 1044

Special Issue Editor


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Guest Editor
Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia
Interests: cancer; tumor; diagnosis; genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As you are aware, in the last few decades, tumor genomics, transcriptomics and proteomics became requisite information for precise diagnostics that leads to precise and effective therapy. With the development of molecular methods and accumulation of knowledge about tumor biology, behavior and progression, new biomarkers arise almost daily. In this Special Issue, we aim to collect recent advances in the field—both basic research-oriented papers from the field of tumor genomics and papers about development of new approaches in applied genomics. We hope that this issue will cover one of many subjects in this promising field, such as:

  • Genomic as a basis for molecular diagnostics;
  • Description of new cancer biomarkers;
  • Cancer genomics insights;
  • Development of precision medicine;
  • Prediction methods in cancer biology;
  • Clinical relevance of tumor genomics data.

Prof. Dr. Petra Korać
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor biology
  • cancer genomics
  • molecular diagnostics
  • biomarkers
  • precision medicine

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Published Papers (1 paper)

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Research

13 pages, 2194 KiB  
Article
Gene Expression Aberrations in Alcohol-Associated Hepatocellular Carcinoma
by Andreja Petrović, Paula Štancl, Paula Gršković, Suzana Hančić, Rosa Karlić, Slavko Gašparov and Petra Korać
Int. J. Mol. Sci. 2024, 25(19), 10558; https://doi.org/10.3390/ijms251910558 - 30 Sep 2024
Viewed by 501
Abstract
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, ranking as the sixth most common cancer worldwide and the fourth leading cause of cancer-related deaths. Most HCC cases originate from cirrhotic livers, typically due to chronic liver diseases, such as hepatitis B [...] Read more.
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, ranking as the sixth most common cancer worldwide and the fourth leading cause of cancer-related deaths. Most HCC cases originate from cirrhotic livers, typically due to chronic liver diseases, such as hepatitis B (HBV) and hepatitis C (HCV) infections, and alcoholism. HCC cells often harbor numerous somatic mutations that are implicated in HCC development, but epigenetic factors, such as miRNA interference, can also affect HCC initiation and progress. miRNA-221 has been explored as a factor affecting HCC development in HCC of viral etiology, but little is known about its effects on gene expression in alcohol-associated HCC. This study aimed to explore potentially similar gene expression aberrations underlying viral and alcohol-induced HCC. We analyzed available transcriptome data from non-tumor hepatocytes and viral-induced HCC tissues. The most notable differences in gene expression associated with miRNA-221 between non-tumor hepatocytes and viral-induced HCC involved NTF-3 and MYBL1 genes. To assess these data in alcohol-induced HCC, we examined 111 tissue samples: tumor tissue and cirrhotic tissue samples from 37 HCC patients and 37 samples from non-tumor liver tissue using RT-Q PCR. We found no significant difference in NTF-3 expression, but MYBL1 expression was significantly lower in HCC tissue compared to non-tumor hepatocytes and cirrhotic tissue. Our findings highlight the importance of the MYBL1 gene in HCC development and emphasize the need for diverse approaches in evaluating tumor mechanisms. Full article
(This article belongs to the Special Issue Molecular Diagnostics and Genomics of Tumors)
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