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Medicina
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Advances in Clinical Medicine and Dentistry
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Advances in Clinical Medicine and Dentistry

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 993

Special Issue Editors

Prof. Dr. Radu Iliescu

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Guest Editor
Department of Pharmacology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: physiology; pharmacology; baroreflex; blood pressure; hypertension; heart rate; cardiovascular
Special Issues, Collections and Topics in MDPI journals
Dr. Ionut Luchian

E-Mail Website
Guest Editor
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: salivary research; ortho-perio; cytokines; biomarkers; finite element method; periodontology
Special Issues, Collections and Topics in MDPI journals
Dr. Mihaela Moscalu

E-Mail Website
Guest Editor
Department of Preventive Medicine and Interdisciplinarity, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: physiology; biomarker; predictive modeling; risk classification methods; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The involvement of biomarkers in predictive modeling and their inclusion in the risk assessment of clinical events has seen significant development in recent years. These aspects are essential for personalized medicine, allowing for tailored approaches to disease prevention, diagnosis, treatment and monitoring. Biomarkers are key to an early and accurate diagnosis, as well as risk assessment and prognosis, providing measurable indicators of individual characteristics and guiding personalized treatment strategies.

This Special Issue aims to collect papers that highlight the use of biomarkers in preventive, diagnostic, therapeutic and prognostic medicine. We also focus our attention on the involvement of biomarkers in public health and their current use in clinical practice.

Currently, there are only a limited number of predictors available, but the development and addition of predictive markers could have a significant impact. Interest in biomarkers has increased, and new methodologies have been developed to evaluate their utility. Biomarker discovery and validation are of particular interest for the advancement of personalized medicine. Analytical techniques are available to quantify the added value of biomarkers, highlighting both their strengths and limitations. While some biomarkers may be relevant to both clinical medicine and dentistry, dentistry has its own unique set of biomarkers that are relevant to oral health, diagnosis and management of dental conditions. In the future, preventive and predictive biomarkers will play a key role in healthcare.

Original articles, reviews, systematic reviews, meta-analyses and case reports are welcomed.

Prof. Dr. Radu Iliescu
Dr. Ionut Luchian
Dr. Mihaela Moscalu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • physiology
  • biomarker
  • predictive modeling
  • risk classification methods
  • salivary diagnosis
  • cytokines
  • systemic diseases
  • genetics
  • microbiology
  • pharmacology
  • biostatistics

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Published Papers (1 paper)

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Research

10 pages, 294 KiB  
Article
The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth
by Maria Hakobyan, Gayane Manrikyan, Marina Markaryan, Izabella Vardanyan and Mikayel Manrikyan
Medicina 2024, 60(7), 1176; https://doi.org/10.3390/medicina60071176 - 19 Jul 2024
Viewed by 663
Abstract
Background and Objectives: Epidemiological and microbiological–immunological studies have led to the conclusion that periodontal disease may be a risk factor for preterm birth. The aim of this study was to investigate and identify the relationship of some hematological cellular biomarkers characterizing the [...] Read more.
Background and Objectives: Epidemiological and microbiological–immunological studies have led to the conclusion that periodontal disease may be a risk factor for preterm birth. The aim of this study was to investigate and identify the relationship of some hematological cellular biomarkers characterizing the chronic oral focus of infection with pregnancy outcomes and their impact on those outcomes. Materials and Methods: Clinical and laboratory tests were conducted on 100 pregnant women, grouped by full-term or preterm births, with the assessment of the following markers: DMF, CPI and PIRI, PHP, microbiological examination of periodontal pockets and amniotic fluid, WBS count, WBCSI, LGI, and NMR. A statistical analysis was carried out with SPSS Statistics version 19.0. Results: Women with preterm labor had higher-grade caries (CSL > 0.3), while women with full-term childbirth had moderate caries (CSL < 0.3). A satisfactory level of oral hygiene efficiency was found in 50% (group 1) and 38.1% (group 2) of the expectant mothers. The periodontal status by the PIRI showed tissue lesions in 20.7% (group 1) and 92.9% (group 2) of the women. The WBCSI was 2.27 ± 0.82 and 2.15 ± 0.68, the NMR was 9.29 ± 5.119 and 11.62 ± 7.78, and the LGI was 3.54 ± 1.1 and 3.73 ± 0.81 in groups 1 and 2, respectively. Comparative analysis of bacterial contamination of the amniotic fluid revealed the predominance of Fusobacterium nucleatum (64.3%), Tannerella forsythia (57.1%), Prevotella intermedia (50%), Porphyromonas gingivalis (57.1%), Staphylococcus aureus (45.2%), and Candida albicans (50%) in women with premature birth. Conclusions: In women with preterm birth, the values of the indices characterizing a chronic oral focus of infection evoke more significant correlations with the timing of delivery, which indicates the significant role of an oral focus of infection. The presence of microbial invasion of amniotic fluid may indicate the role of periodontopathogenic bacteria in pregnant women diagnosed with a risk of preterm birth. Full article
(This article belongs to the Special Issue Advances in Clinical Medicine and Dentistry)
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