International Journal of Molecular Sciences

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Wound Repair: From Basic Biology to Tissue Engineering

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Dear Colleagues,

The field of wound repair has advanced significantly, encompassing fundamental biological mechanisms to sophisticated tissue engineering strategies. This Special Issue aims to bridge the gap between basic research on and translational applications in wound healing and tissue regeneration. It will focus on the cellular and molecular dynamics of wound repair, including inflammation, angiogenesis, extracellular matrix remodeling, and stem cell involvement. Additionally, it will explore the latest developments in biomaterials, 3D bioprinting, and bioactive scaffolds tailored for enhanced healing. By integrating perspectives from basic biology, clinical challenges, and engineering innovations, this Special Issue seeks to foster interdisciplinary collaboration and advance the development of next-generation solutions for acute and chronic wounds. Submissions covering experimental research, reviews, and cutting-edge technologies are welcome, particularly those that illuminate mechanisms, novel therapies, and their clinical implications.

This Special Issue is supervised by Professor Judyta Cielecka-Piontek and Dr. Magdalena Paczkowska-Walendowska.

Dr. Magdalena Paczkowska-Walendowska
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22 pages, 7949 KiB

Open AccessArticle

lncRNAs GAS5 and MALAT1 Contained in Human Adipose Stem Cell (hASC)-Derived Exosomes Drive the Cell-Free Repair and Regeneration of Wounds In Vivo

by Meredith Krause-Hauch, Rekha S. Patel, Bangmei Wang, Brenna Osborne, Brianna Jones, Paul Albear and Niketa A. Patel

Int. J. Mol. Sci. 2025, 26(8), 3479; https://doi.org/10.3390/ijms26083479 - 8 Apr 2025

Viewed by 185

Abstract

Wound healing progresses through four phases: hemostasis, inflammation, proliferation, and remodeling. Wounds may become chronic if this process is disrupted. The use of small extracellular vesicle (sEV; EVs < 200 nm) exosomes (exo; ~40–120 nm) derived from human adipose stem cells (hASCs) as a treatment for wounds is well studied. The cargo of these exosomes is of great interest as this accelerates wound healing. Our previous studies identified lncRNAs GAS5 and MALAT1 as packaged and enriched in hASC exosomes. In this study, we use a rat model to examine the effects on wound healing when hASC exosomes are depleted of GAS5 and MALAT1. Rats were wounded and wounds were treated with 100 μg hASC_exo or hASC_exo-G-M every 2 days for 1 week. qPCR was completed to evaluate the molecular effects of depletion of GAS5 and MALAT1 from hASC_exo. RNAseq was performed on wound tissue to evaluate the molecular mechanisms changed by hASC_exo-G-M in wound healing. While hASC_exo-G-M significantly improved wound healing rate compared to control wounds, healing occurred slower than in wounds treated with hASC_exo that were not depleted of GAS5 and MALAT1. Overall, this study reveals that molecular functions associated with healing are reduced in the absence of GAS5 and MALAT1, highlighting the importance of these lncRNAs. Full article

(This article belongs to the Special Issue Wound Repair: From Basic Biology to Tissue Engineering)

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