The Novel Approach in the Anticancer Agents: From Design to Formulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 1568
Special Issue Editor
2. BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic
3. Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
Interests: nature compounds; drug delivery system; formulation; oncological diseases; neurodegenerative diseases
Special Issue Information
Dear Colleagues,
Despite tremendous research efforts and advances, cancer unfortunately continues to take its terrible toll. Given its complexity and heterogeneity, it is difficult to choose the right molecular target and the appropriate method of targeting. The side effects of the therapies used are very harmful for the patients and can strongly decrease their therapeutic potential. Additionally, the long delay between discovery and application and the enormous financial requirements of pharmaceutical research are significant limiting factors. They could be used also as nature agents, but their effectivity can be often limited due to low solubility and bioactivity.
On the other hand, some promising strategies (drug delivery system, reformulation, repurposing, and combination therapy) are studied and used for overcoming the above obstacles. For example, commercially available liposomal formulations display significantly lower levels of cardiotoxicity of doxorubicin and can sometimes improve the bioactivity of nature compounds. The combination of polyphenolic compounds and anticancer therapies can display a strong synergic anticancer effect and lower side effects.
This Special Issue, “The Novel Approach in the Anticancer Agents: From Design to Formulation”, invites researchers to contribute with original research or updated review articles that are focused on an increase in the effectivity of clinically used drugs and nature agents by DDS, formulation, or their combination, and repurposing used drugs for cancer treatment. Nevertheless, articles, inspired structure motifs of used anticancer agents, and/or studies of interesting molecular targets are also welcomed.
I would like to dedicate this Special Issue to the memory of my supervisor, prof. Vladimír Král Dr.Sc., whose lifelong approach is displayed by this philosophy. This Special Issue will honor his memory.
Dr. Zdeněk Kejik
Guest Editor
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Keywords
- drug delivery systems
- formulation and reformulation drug and nature agents
- drug repurposing
- combination therapy
- molecular docking
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