Bile Acids and Bile Acid Modifications in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 19
Special Issue Editor
2. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Interests: metabolites; bile acid modifications; bile acid
Special Issue Information
Dear Colleagues,
The human gut microbiota produces a diverse array of metabolites, which are crucial for maintaining health and regulating metabolic pathways. Among these, bile acids are of particular interest due to their pivotal roles in regulating glucose and lipid metabolism, as well as energy expenditure. Recent advancements have revealed numerous previously unrecognized bile acids modifications, such as sulfation, epimerization, isomerization, or acylation, that exert important signaling functions affecting both gut microbiota and host health.
This Special Issue seeks original research articles and comprehensive reviews that delve into the following areas:
- The discovery and characterization of novel bile acid modifications and their implications for metabolic health.
- The impact of exercise, diet/supplements, and metabolic surgery interventions on bile acid levels, i.e., circulating, luminal and feces, and the role of gut microbiota.
- Mechanistic insights into how novel bile acids influence glucose regulation, lipid metabolism and energy expenditure.
- Molecular pathways through which these metabolites mediate their effects in health and disease, and in response to various interventions.
This Special Issue provides a unique opportunity to contribute to an expanding field of research with significant potential for uncovering novel therapeutic targets and intervention strategies for metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. By enhancing our understanding of how novel bile acids modulate metabolism, we aim to lay the groundwork for future studies and clinical applications.
Dr. Francisco J. Osuna-Prieto
Guest Editor
Manuscript Submission Information
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Keywords
- bile acids
- bile acid modifications
- bile acid signaling
- bile acid metabolism
- metabolic disorders
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