Primary Mitochondrial Diseases and Secondary Mitochondrial Dysfunction: New Insights and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 3713
Special Issue Editor
Interests: mitochondria; biophysics; diabetes mellitus; myopathy; mitochondrial Ca2+ transport; permeability transition pore; oxidative stress; reactive oxygen species; lipids; membrane proteins; liposomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
New developments in the field of genetic methodology and molecular techniques have allowed us to recognize mitochondrial disorders as more complex and multifactorial than originally thought. At present, the terms “primary mitochondrial disease” and “secondary mitochondrial dysfunction” have been widely used to characterize mitochondrial pathophysiology. Primary mitochondrial diseases are clinically heterogeneous diseases associated with changes in genetic material (e.g., deletions, depletions, mutations) within the DNA of mitochondria (mtDNA) or cell nuclei (nDNA), affecting mainly nervous and muscular tissues. Beyond the disorders recognized as mitochondrial diseases, abnormalities in the ultrastructure and function of mitochondria in cells have been revealed in a number of unrelated pathologies. These include diabetes mellitus, cardiovascular pathologies, myopathies, cancers, organ-specific (e.g., eye or liver) disorders, ageing, as well as neurologic and immune diseases. In addition, multiple lines of evidence have suggested mitochondrial dysfunction as a mechanism for pharmaceutical-drug-induced toxicity in the heart, brain, liver, and other organs and tissues. The accumulated knowledge in these areas requires research aimed at clarifying open questions.
This Special Issue is focused on the molecular and cellular mechanisms leading to mitochondrial disorders, with particular attention to molecules involved in the regulation of mitochondrial dynamics, biogenesis, and mitophagy. Especially, studies employing novel therapeutic approaches targeting mitochondria and redox dyshomeostasis to improve treatment outcomes will be given priority. Additionally, research papers and review articles exploring the effects of mitochondrial therapy on cell pathologies will also be included.
Prof. Dr. Konstantin Belosludtsev
Guest Editor
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Keywords
- mitochondria
- mitochondrial DNA
- mitochondrial dynamics
- mitophagy
- mitochondrial toxicity
- apoptosis
- primary mitochondrial disease
- secondary mitochondrial dysfunction
- mitochondria-targeted drug discovery
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