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Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 1781

Special Issue Editors

Prof. Dr. Ramona Suharoschi

E-Mail Website
Guest Editor
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Manastur Street, 400372 Cluj-Napoca, Romania
Interests: nutrigenomics; metagenomics; metaproteomics; metabolomics; metatranscriptomics; understanding the molecular mechanisms of food compounds; molecular nutrition; personalised nutrition; personalised food; medical foods; aging and chronic disease; aging and NCDs; climate/environment, health, and improved nutrition; diet and cancer; dietary bioactive components; prebiotics fiber; nutrient-gene interactions; nutritional epidemiology; nutritional immunology and inflammation; obesity and microbiome; gut-brain axis; nutritional microbiology
Special Issues, Collections and Topics in MDPI journals
Dr. Oana Lelia Pop

E-Mail Website
Guest Editor
Department of Food Science, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Interests: polyphenols; bioavailability; bio-accessibility; bioactivity; antioxidant; biotechnological; chemical treatment
Special Issues, Collections and Topics in MDPI journals
Dr. Adriana Fodor

E-Mail Website
Guest Editor
Clinical Center of Diabetes, Nutrition and Metabolic Diseases, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2-4 Clinicilor St., 400012 Cluj-Napoca, Romania
Interests: oxidative stress; antioxidant polyphenols, anti-inflammatory; antimicrobial polyphenols; bioactive compound; biological activities

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the multifaceted roles of phytochemicals in offering antioxidant, anti-inflammatory, and antimicrobial benefits. It seeks to bridge traditional medicinal knowledge with modern molecular science, providing insights into the mechanisms of action, biomedical applications, and potential therapeutic benefits of these natural compounds.

For this Special Issue on "Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights", we welcome your contributions in the form of original research and review articles on all aspects of the pathogenesis of the areas of biochemistry, molecular biology, cell biology, and molecular medicine to create a comprehensive picture of how phytochemicals can contribute to health and disease management.

Topics of Interest:

  • Mechanistic Insights into the Antioxidant Actions of Phytochemicals: studies revealing molecular pathways through which phytochemicals exert antioxidant effects.
  • Anti-Inflammatory Phytochemicals—From Traditional Use to Molecular Evidence: research papers and reviews that discuss traditional plants' anti-inflammatory properties and their active compounds.
  • Phytochemicals as Antimicrobial Agents: investigations into the effectiveness of plant-derived compounds against various microbial pathogens.
  • Synergy and Interactions: studies exploring the synergistic effects of phytochemicals in combinations and their interactions with pharmaceuticals.
  • Technological Advances in Phytochemical Research: papers on novel techniques and methodologies in phytochemicals' extraction, analysis, and bioavailability studies.
  • Safety, Toxicity, and Regulatory Aspects: research on the safety profile, potential toxicity, and regulatory considerations of phytochemical-based treatments.

Prof. Dr. Ramona Suharoschi
Dr. Oana Lelia Pop
Dr. Adriana Fodor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals

  • antioxidant activities
  • anti-inflammatory properties
  • antimicrobial effects
  • molecular mechanisms
  • clinical applications
  • traditional medicine
  • bioavailability
  • safety and toxicology and regulatory aspects of phytochemicals
  • pharmacological interaction

Published Papers (2 papers)

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20 pages, 1372 KiB  
Article
Plantago major and Plantago lanceolata Exhibit Antioxidant and Borrelia burgdorferi Inhibiting Activities
by Pille-Riin Laanet, Olga Bragina, Piia Jõul and Merike Vaher
Int. J. Mol. Sci. 2024, 25(13), 7112; https://doi.org/10.3390/ijms25137112 - 28 Jun 2024
Viewed by 321
Abstract
Lyme disease, caused by Borrelia burgdorferi sensu lato infection, is the most widespread vector-borne illness in the Northern Hemisphere. Unfortunately, using targeted antibiotic therapy is often an ineffective cure. The antibiotic resistance and recurring symptoms of Lyme disease are associated with the formation [...] Read more.
Lyme disease, caused by Borrelia burgdorferi sensu lato infection, is the most widespread vector-borne illness in the Northern Hemisphere. Unfortunately, using targeted antibiotic therapy is often an ineffective cure. The antibiotic resistance and recurring symptoms of Lyme disease are associated with the formation of biofilm-like aggregates of B. burgdorferi. Plant extracts could provide an effective alternative solution as many of them exhibit antibacterial or biofilm inhibiting activities. This study demonstrates the therapeutic potential of Plantago major and Plantago lanceolata as B. burgdorferi inhibitors. Hydroalcoholic extracts from three different samples of each plant were first characterised based on their total concentrations of polyphenolics, flavonoids, iridoids, and antioxidant capacity. Both plants contained substantial amounts of named phytochemicals and showed considerable antioxidant properties. The major non-volatile constituents were then quantified using HPLC-DAD-MS analyses, and volatile constituents were quantified using HS-SPME-GC-MS. The most prevalent non-volatiles were found to be plantamajoside and acteoside, and the most prevalent volatiles were β-caryophyllene, D-limonene, and α-caryophyllene. The B. burgdorferi inhibiting activity of the extracts was tested on stationary-phase B. burgdorferi culture and its biofilm fraction. All extracts showed antibacterial activity, with the most effective lowering the residual bacterial viability down to 15%. Moreover, the extracts prepared from the leaves of each plant additionally demonstrated biofilm inhibiting properties, reducing its formation by 30%. Full article
(This article belongs to the Special Issue Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights)
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Review

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20 pages, 2041 KiB  
Review
Phytonanotherapy for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Livhuwani P. Nendouvhada, Nicole R. S. Sibuyi, Adewale O. Fadaka, Samantha Meyer, Abram M. Madiehe, Mervin Meyer and Kwazikwakhe B. Gabuza
Int. J. Mol. Sci. 2024, 25(11), 5571; https://doi.org/10.3390/ijms25115571 - 21 May 2024
Viewed by 794
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, diabetes, hyperlipidemia, and hypertriglyceridemia. MASLD in 43–44% of patients can progress to metabolic dysfunction-associated steatohepatitis (MASH), and [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease, is a steatotic liver disease associated with metabolic syndrome (MetS), especially obesity, hypertension, diabetes, hyperlipidemia, and hypertriglyceridemia. MASLD in 43–44% of patients can progress to metabolic dysfunction-associated steatohepatitis (MASH), and 7–30% of these cases will progress to liver scarring (cirrhosis). To date, the mechanism of MASLD and its progression is not completely understood and there were no therapeutic strategies specifically tailored for MASLD/MASH until March 2024. The conventional antiobesity and antidiabetic pharmacological approaches used to reduce the progression of MASLD demonstrated favorable peripheral outcomes but insignificant effects on liver histology. Alternatively, phyto-synthesized metal-based nanoparticles (MNPs) are now being explored in the treatment of various liver diseases due to their unique bioactivities and reduced bystander effects. Although phytonanotherapy has not been explored in the clinical treatment of MASLD/MASH, MNPs such as gold NPs (AuNPs) and silver NPs (AgNPs) have been reported to improve metabolic processes by reducing blood glucose levels, body fat, and inflammation. Therefore, these actions suggest that MNPs can potentially be used in the treatment of MASLD/MASH and related metabolic diseases. Further studies are warranted to investigate the feasibility and efficacy of phytonanomedicine before clinical application. Full article
(This article belongs to the Special Issue Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights)
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