New Perspectives on Drugs Targeting Lipid-Transfer Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 10741
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inter-organelle trafficking of membrane lipids is largely mediated by lipid transfer proteins (LTPs). These proteins possess domains with hydrophobic cavities that stabilize lipids and enable their transport between membranes across the aqueous phase of the cytosol. Besides the structural description of many LTPs, considerable progress has been made in our understanding of their functions at the molecular, cellular and physiological levels. It is clear that LTPs play a fundamental role in membrane biogenesis and signaling, and their malfunction can contribute to several diseases. In recent years, the development of pharmacology that specifically inhibits LTPs has shed new light on their mechanism of action and their importance in different pathophysiological contexts. One of the key issues is whether targeting LTPs with small molecules inhibitors will offer a promising route for potential treatments, such as for cancers, pathogen infections or metabolic disorders. A better understanding of how these different drugs act at the molecular and cellular levels will be essential to foster the development of effective therapies.
Dr. Bruno Mesmin
Guest Editor
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Keywords
- Lipid-transfer proteins
- Small molecules inhibitors
- Intracellular lipid transport
- Membranes
- Cancer
- Infectious diseases
- Membrane contact sites
- Lipid metabolism
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