Dementia and Cell Theraputic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 12877
Special Issue Editors
Interests: aging; neurodegenerative diseases; brain immunity; microglia; stem cells; hematopoietic stem cells; regenerative medicine; pharmacological modification
Special Issue Information
Dear Colleagues,
It is estimated that 130 million people worldwide will suffer from dementia by 2050. Alzheimer's disease is the most common form of dementia, and there are many brain disorders that lead to the development of dementia (e.g., Lewy body disease), including Parkinson's disease, cerebrovascular disease, Down's syndrome, and Huntington’s disease. Cell therapeutic strategies are an attractive approach to recovering lost brain function. In fact, the improvement of motor function in Parkinson's disease is vigorously promoted by this strategy, and clinical study is now ongoing. Meanwhile, regarding cell therapeutic strategies for recovery of cognitive functions, preclinical studies have been under examination and/or recently launched to establish the proof of concept. The preclinical studies include not only the evaluation of their effectiveness but also the biology of stem cells; development of technologies for production and tracing of therapeutic cells; elucidation of therapeutic mechanism; and application of materials that support survival, function, and safety of therapeutic cells. Contributions to this Special Issue will provide new insights into the possibility of the development of cell-based disease-modifying therapy and the understanding of the pathogenesis of dementia.
Prof. Dr. Kazuyuki Takata
Dr. Daijiro Yanagisawa
Guest Editors
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Keywords
- Alzheimer’s disease
- amyloid-β
- tau
- neurodegeneration
- neuroinflammation
- neurons
- glial cells
- stem cells
- Parkinson’s disease
- Down syndrome
- regeneration
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