Drug Resistance Mechanisms in Bacteria 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 23009
Special Issue Editor
Interests: pathogenic bacteria; drug resistance; vaccine; molecular genetics and biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance is a global problem. Patients with infections caused by drug-resistant bacteria are at risk of worse clinical outcomes. They may consume more health-care resources than others who are infected with non-resistant strains of the same pathogens. Resistance to carbapenems, the last resort treatment in Klebsiella pneumoniae, a common intestinal bacterium that can cause life-threatening infections, has spread worldwide. K. pneumoniae is a major cause of hospital-acquired infections such as pneumonia, bacteremia, and infections in newborns and patients in intensive-care units. Because of resistance, carbapenem antibiotics do not work in more than half of people treated for K. pneumoniae infections. Resistance in E. coli to fluoroquinolone, one of the most widely used antibiotics for treating urinary tract infections, is also pervasive. Colistin is the last resort treatment for life-threatening infections caused by Enterobacteriaceae, which are resistant to carbapenems. Resistance to colistin has recently been detected in several countries, making infections caused by these bacteria untreatable. Various mechanisms can cause drug resistance. One of the most common means involves gene mutations that potentially cause alterations in the drug targets so that the drugs cannot bind the targets. Another common mechanism consists of the expression of higher levels of the targets. The genes responsible for these mechanisms may be chromosomally encoded, or transmissible through plasmids and transposons. In this Special Issue, we plan to continue collecting original research articles, short communications, or review articles discussing bacterial resistance mechanisms' genetic and molecular basis.
Dr. Apichai Tuanyok
Guest Editor
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Keywords
- carbapenem
- fluoroquinolone
- colistin
- cephalosporin
- drug target
- antibiotic resistance
- Klebsiella pneumoniae
- Acinetobacter
- Burkholderia
- beta-lactamase
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